Protein: MED22
Mediator of RNA polymerase II transcription subunit 22 (Mediator complex subunit 22) (Suppressor of RNA polymerase B 6)

Gene: MED22, SRB6
Organism: Saccharomyces cerevisiae S288C
Interactions: 63
UniProt ID: P32570

Gene Ontology (top 5):
GO:0003712 - transcription coregulator activity
GO:0005634 - nucleus
GO:0016592 - mediator complex
GO:0032968 - positive regulation of transcription elongation by RNA polymerase II
GO:0045944 - positive regulation of transcription by RNA polymerase II

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

693517

MED17
Mediator of RNA polymerase II transcription subunit 17

21

0

Small-scale

0.938

High

693615

MED11
Mediator of RNA polymerase II transcription subunit 11

9

0

Small-scale

0.927

High

693579

MED18
Mediator of RNA polymerase II transcription subunit 18

9

0

Small-scale

0.919

High

693586

MED8
Mediator of RNA polymerase II transcription subunit 8

8

0

Small-scale

0.914

High

693588

MED6
Mediator of RNA polymerase II transcription subunit 6

5

0

Small-scale

0.872

High

693608

MED7
Mediator of RNA polymerase II transcription subunit 7

7

0

Small-scale

0.708

High

586274

MED15
Mediator of RNA polymerase II transcription subunit 15

6

0

Small-scale

0.697

High

581342

MED14
Mediator of RNA polymerase II transcription subunit 14

6

0

Small-scale

0.696

High

693581

MED9
Mediator of RNA polymerase II transcription subunit 9

6

0

Small-scale

0.696

High

693583

MED20
Mediator of RNA polymerase II transcription subunit 20

5

0

Small-scale

0.682

High

693594

MED3
Mediator of RNA polymerase II transcription subunit 3

5

0

Small-scale

0.682

High

693598

MED21
Mediator of RNA polymerase II transcription subunit 21

5

0

Small-scale

0.682

High

693606

MED10
Mediator of RNA polymerase II transcription subunit 10

5

0

Small-scale

0.682

High

693612

MED1
Mediator of RNA polymerase II transcription subunit 1

5

0

Small-scale

0.682

High

693613

MED4
Mediator of RNA polymerase II transcription subunit 4

5

0

Small-scale

0.682

High

693601

MED5
Mediator of RNA polymerase II transcription subunit 5

5

0

Small-scale

0.679

High

375322

RPB1
DNA-directed RNA polymerase II subunit RPB1

5

0

Small-scale

0.676

High

686831

MED16
Mediator of RNA polymerase II transcription subunit 16

4

0

Small-scale

0.658

High

693587

MED31
Mediator of RNA polymerase II transcription subunit 31

4

0

Small-scale

0.644

High

693611

MED2
Mediator of RNA polymerase II transcription subunit 2

4

0

Small-scale

0.644

High

693589

SSN2
Mediator of RNA polymerase II transcription subunit 13

3

0

High-throughput

0.634

High

693590

SSN3
Meiotic mRNA stability protein kinase SSN3

3

0

High-throughput

0.634

High

693584

SPT7
Transcriptional activator SPT7

2

1

High-throughput

0.621

High

626016

MED19
Mediator of RNA polymerase II transcription subunit 19

3

0

Small-scale

0.616

High

587829

AP1
AP-1-like transcription factor YAP1

2

0

High-throughput

0.595

High

635983

SRB8
Mediator of RNA polymerase II transcription subunit 12

2

0

High-throughput

0.595

High

693602

ADA2
Transcriptional adapter 2

2

0

High-throughput

0.595

High

693604

GCN5
Histone acetyltransferase GCN5

2

0

High-throughput

0.595

High

693595

T2FB
Transcription initiation factor IIF subunit beta

2

0

Small-scale

0.569

High

693597

SSN8
RNA polymerase II holoenzyme cyclin-like subunit

2

0

High-throughput

0.563

High

693600

TAF6
Transcription initiation factor TFIID subunit 6

2

0

High-throughput

0.563

High

661669

TF2B
Transcription initiation factor IIB

2

0

Small-scale

0.559

High

510650

SSB1
Ribosome-associated molecular chaperone SSB1

2

1

High-throughput

0.552

High

419838

SNF1
Carbon catabolite-derepressing protein kinase

1

0

Small-scale

0.518

High

381533

GAL4
Regulatory protein GAL4

1

0

Small-scale

0.458

High

693585

TAF14
Transcription initiation factor TFIID subunit 14

1

0

High-throughput

0.458

High

693610

TAF10
Transcription initiation factor TFIID subunit 10

1

0

High-throughput

0.458

High

693614

SMC6
Structural maintenance of chromosomes protein 6

1

0

High-throughput

0.458

High

490672

HSP71
Heat shock protein SSA1

1

1

High-throughput

0.445

High

493484

HSP72
Heat shock protein SSA2

1

1

High-throughput

0.445

High

693580

HSP7F
Heat shock protein homolog SSE1

1

2

High-throughput

0.445

High

693593

SSB2
Ribosome-associated molecular chaperone SSB2

1

1

High-throughput

0.445

High

376693

PABP
Polyadenylate-binding protein, cytoplasmic and nuclear

1

0

High-throughput

0.426

High

415922

DED1
ATP-dependent RNA helicase DED1

1

0

High-throughput

0.426

High

498846

RL4A
Large ribosomal subunit protein uL4A

1

0

High-throughput

0.426

High

693603

MLP1
Protein MLP1

2

0

High-throughput

0.324

High

534717

RL30
Large ribosomal subunit protein eL30

1

0

High-throughput

0.279

Low

535200

RS17B
Small ribosomal subunit protein eS17B

1

0

High-throughput

0.279

Low

564248

RL8A
Large ribosomal subunit protein eL8A

1

0

High-throughput

0.279

Low

693591

RS14B
Small ribosomal subunit protein uS11B

1

0

High-throughput

0.279

Low

693596

RL17B
Large ribosomal subunit protein uL22B

1

0

High-throughput

0.279

Low

693592

LAA1
AP-1 accessory protein LAA1

1

0

High-throughput

0.249

Low

693607

VAM6
Vacuolar morphogenesis protein 6

1

0

High-throughput

0.249

Low

367869

EF1A
Elongation factor 1-alpha

1

0

High-throughput

0.232

Low

383024

RL25
Large ribosomal subunit protein uL23

1

0

High-throughput

0.232

Low

424409

PYR1
Multifunctional protein URA2

1

0

High-throughput

0.232

Low

470938

RS22A
Small ribosomal subunit protein uS8A

1

0

High-throughput

0.232

Low

478020

HSP77
Import motor subunit, mitochondrial

1

0

High-throughput

0.232

Low

555909

VATB
V-type proton ATPase subunit B

1

0

High-throughput

0.232

Low

693582

HSP78
Heat shock protein 78, mitochondrial

1

0

High-throughput

0.232

Low

693599

IMDH3
Inosine-5'-monophosphate dehydrogenase 3

1

0

High-throughput

0.232

Low

693605

RRP5
rRNA biogenesis protein RRP5

1

0

High-throughput

0.232

Low

693609

TFB4
General transcription and DNA repair factor IIH subunit TFB4

1

0

Small-scale

0.232

Low


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Last updated: 15 Jul 2024