Protein: CWC2
Pre-mRNA-splicing factor CWC2 (Complexed with CEF1 protein 2) (PRP19-associated complex protein 40) (Synthetic lethal with CLF1 protein 3)

Gene: CWC2
Organism: Saccharomyces cerevisiae S288C
Interactions: 80
UniProt ID: Q12046

Gene Ontology (top 5):
GO:0000387 - spliceosomal snRNP assembly
GO:0000398 - mRNA splicing, via spliceosome
GO:0000974 - Prp19 complex
GO:0007049 - cell cycle
GO:0017070 - U6 snRNA binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

704732

PRP8
Pre-mRNA-splicing factor 8

6

5

Small-scale

0.949

High

997042

RU2A
U2 small nuclear ribonucleoprotein A'

5

8

Small-scale

0.922

High

598656

ISY1
Pre-mRNA-splicing factor ISY1

3

2

High-throughput

0.847

High

629404

BUD31
Pre-mRNA-splicing factor BUD31

3

2

High-throughput

0.839

High

809554

CWC26
Pre-mRNA-splicing factor CWC26

3

1

High-throughput

0.839

High

980237

RSE1
Pre-mRNA-splicing factor RSE1

3

4

High-throughput

0.839

High

996584

NCBP2
Nuclear cap-binding protein subunit 2

3

9

High-throughput

0.827

High

775706

IST3
U2 snRNP component IST3

3

9

High-throughput

0.805

High

710235

NCBP1
Nuclear cap-binding protein complex subunit 1

2

1

High-throughput

0.789

High

775730

MSL1
U2 small nuclear ribonucleoprotein B''

2

11

High-throughput

0.776

High

692372

PRP19
Pre-mRNA-processing factor 19

11

4

Small-scale

0.761

High

977086

CEF1
Pre-mRNA-splicing factor CEF1

7

5

Small-scale

0.748

High

971701

CUS1
Cold sensitive U2 snRNA suppressor 1

2

2

High-throughput

0.737

High

1014931

HSH49
Protein HSH49

2

10

High-throughput

0.737

High

655767

PRP45
Pre-mRNA-processing protein 45

6

5

Small-scale

0.735

High

1014927

CLF1
Pre-mRNA-splicing factor CLF1

6

8

Small-scale

0.733

High

657777

YJU2
Splicing factor YJU2

6

2

Small-scale

0.732

High

697275

BRR2
Pre-mRNA-splicing helicase BRR2

5

13

Small-scale

0.718

High

978485

SYF1
Pre-mRNA-splicing factor SYF1

5

7

Small-scale

0.718

High

1014929

PRP46
Pre-mRNA-splicing factor PRP46

5

3

Small-scale

0.718

High

731784

SN114
Pre-mRNA-splicing factor SNU114

4

4

High-throughput

0.699

High

778644

PRP17
Pre-mRNA-processing factor 17

4

4

High-throughput

0.699

High

766972

RSMB
Small nuclear ribonucleoprotein-associated protein B

4

6

High-throughput

0.694

High

873677

RUXF
Small nuclear ribonucleoprotein F

4

4

High-throughput

0.687

High

746886

SLT11
Pre-mRNA-splicing factor SLT11

3

2

High-throughput

0.667

High

795431

SMD3
Small nuclear ribonucleoprotein Sm D3

3

6

High-throughput

0.667

High

861585

CWC22
Pre-mRNA-splicing factor CWC22

3

1

High-throughput

0.667

High

970250

SMD1
Small nuclear ribonucleoprotein Sm D1

3

2

High-throughput

0.667

High

864802

CWC24
Pre-mRNA-splicing factor CWC24

1

0

High-throughput

0.656

High

865377

CWC25
Pre-mRNA-splicing factor CWC25

3

1

High-throughput

0.650

High

986606

SMD2
Small nuclear ribonucleoprotein Sm D2

3

1

High-throughput

0.650

High

589464

PRP2
Pre-mRNA-splicing factor ATP-dependent RNA helicase-like protein PRP2

3

10

Small-scale

0.646

High

622347

PRP22
Pre-mRNA-splicing factor ATP-dependent RNA helicase PRP22

3

10

Small-scale

0.646

High

861082

SYF2
Pre-mRNA-splicing factor SYF2

3

0

High-throughput

0.638

High

985863

SN309
Pre-mRNA-splicing factor SNT309

3

0

High-throughput

0.638

High

971114

SPP2
Pre-mRNA-splicing factor SPP2

3

0

Small-scale

0.632

High

976134

CWC21
Pre-mRNA-splicing factor CWC21

3

0

Small-scale

0.628

High

748096

NTC20
Pre-mRNA-splicing factor NTC20

3

0

High-throughput

0.622

High

977580

CWC15
Pre-mRNA-splicing factor CWC15

3

0

High-throughput

0.622

High

376966

PABP
Polyadenylate-binding protein, cytoplasmic and nuclear

1

7

High-throughput

0.618

High

586537

PRP9
Pre-mRNA-splicing factor PRP9

1

3

High-throughput

0.618

High

991154

PRP11
Pre-mRNA-splicing factor PRP11

1

4

High-throughput

0.618

High

602778

MCK1
Protein kinase MCK1

1

5

High-throughput

0.579

High

1014930

SKM1
Serine/threonine-protein kinase SKM1

1

1

High-throughput

0.579

High

859454

PRP43
Pre-mRNA-splicing factor ATP-dependent RNA helicase PRP43

2

9

High-throughput

0.574

High

770345

RUXG
Small nuclear ribonucleoprotein G

2

7

High-throughput

0.571

High

836947

SF3B1
U2 snRNP component HSH155

2

6

High-throughput

0.571

High

495230

HSP72
Heat shock protein SSA2

2

4

High-throughput

0.504

High

513094

SSB1
Ribosome-associated molecular chaperone SSB1

2

7

High-throughput

0.504

High

752276

KIC1
Serine/threonine-protein kinase KIC1

1

0

High-throughput

0.494

High

856946

CWC23
Pre-mRNA-splicing factor CWC23

1

2

High-throughput

0.489

High

554253

PRP16
Pre-mRNA-splicing factor ATP-dependent RNA helicase PRP16

1

10

High-throughput

0.479

High

692438

PRP21
Pre-mRNA-splicing factor PRP21

1

4

High-throughput

0.479

High

989433

RDS3
Pre-mRNA-splicing factor RDS3

1

3

High-throughput

0.479

High

704973

PRP18
Pre-mRNA-splicing factor 18

1

0

High-throughput

0.458

High

785265

MPG1
Mannose-1-phosphate guanyltransferase

1

1

High-throughput

0.445

High

837307

IMDH4
Inosine-5'-monophosphate dehydrogenase 4

1

2

High-throughput

0.445

High

860788

DRN1
CWF19-like protein DRN1

1

2

High-throughput

0.445

High

389750

CDC25
Cell division control protein 25

1

0

High-throughput

0.426

High

431155

CDC4
Cell division control protein 4

1

1

High-throughput

0.417

High

774380

NU159
Nucleoporin NUP159

1

1

High-throughput

0.417

High

368488

EF1A
Elongation factor 1-alpha

1

4

High-throughput

0.407

High

556358

VATB
V-type proton ATPase subunit B

1

2

High-throughput

0.407

High

572066

CLC1
Clathrin light chain

1

2

High-throughput

0.407

High

681067

HS104
Heat shock protein 104

1

3

High-throughput

0.407

High

695743

HSP7F
Heat shock protein homolog SSE1

1

6

High-throughput

0.407

High

769730

SSB2
Ribosome-associated molecular chaperone SSB2

1

7

High-throughput

0.407

High

977811

WDR59
Maintenance of telomere capping protein 5

1

2

High-throughput

0.407

High

1014928

HSP42
Heat shock protein 42

1

1

High-throughput

0.407

High

987202

SP382
Pre-mRNA-splicing factor SPP382

2

0

High-throughput

0.328

High

733101

NTR2
Pre-mRNA-splicing factor NTR2

2

0

High-throughput

0.318

High

972433

SLU7
Pre-mRNA-splicing factor SLU7

2

0

High-throughput

0.318

High

733486

YK21
Uncharacterized protein YKR041W

1

0

High-throughput

0.249

Low

747094

IST2
Increased sodium tolerance protein 2

1

0

High-throughput

0.249

Low

749060

SSH1
Sec sixty-one protein homolog

1

0

High-throughput

0.238

Low

987236

TDA5
Uncharacterized oxidoreductase TDA5

1

0

High-throughput

0.238

Low

605810

SLY1
Protein SLY1

1

0

High-throughput

0.232

Low

677122

ATP7
ATP synthase subunit d, mitochondrial

1

0

High-throughput

0.232

Low

969393

RM13
Large ribosomal subunit protein mL50

1

0

High-throughput

0.232

Low

996578

FEX1
Fluoride export protein 1

1

0

High-throughput

0.232

Low


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Last updated: 15 Jul 2024