Protein: LAG1
Ceramide synthase LAG1 (Longevity assurance factor 1) (Longevity assurance gene 1 protein) (Longevity assurance protein 1) (Very-long-chain ceramide synthase LAG1) (EC 2.3.1.297)

Gene: LAG1
Organism: Saccharomyces cerevisiae S288C
Interactions: 53
UniProt ID: P38703

Gene Ontology (top 5):
GO:0005783 - endoplasmic reticulum
GO:0005789 - endoplasmic reticulum membrane
GO:0046513 - ceramide biosynthetic process
GO:0050291 - sphingosine N-acyltransferase activity
GO:0061576 - acyl-CoA ceramide synthase complex

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

659156

LAC1
Ceramide synthase LAC1

5

6

Small-scale

0.724

High

752777

LIP1
Ceramide synthase subunit LIP1

4

1

Small-scale

0.706

High

707418

OSTB
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit WBP1

2

1

High-throughput

0.614

High

601695

SEC62
Translocation protein SEC62

2

3

High-throughput

0.600

High

752776

OSTD
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit SWP1

2

0

High-throughput

0.588

High

630720

AGP1
General amino acid permease AGP1

1

3

High-throughput

0.541

High

752768

SPC1
Signal peptidase complex subunit 1

1

2

High-throughput

0.541

High

752771

GPI8
GPI-anchor transamidase

1

1

High-throughput

0.541

High

752773

ERG25
C-4 methylsterol oxidase ERG25

1

1

High-throughput

0.541

High

716145

CSG2
Mannosyl phosphorylinositol ceramide synthase regulatory protein CSG2

1

0

High-throughput

0.518

High

752758

ERP5
Protein ERP5

1

0

High-throughput

0.518

High

752761

CHS7
Chitin synthase export chaperone

1

0

High-throughput

0.518

High

752786

ECM3
Protein ECM3

1

0

High-throughput

0.518

High

752757

COS8
Protein COS8

1

1

High-throughput

0.494

High

752772

AVT4
Vacuolar amino acid transporter 4

1

1

High-throughput

0.494

High

752770

MNN11
Probable alpha-1,6-mannosyltransferase MNN11

1

0

High-throughput

0.486

High

752782

DSC3
DSC E3 ubiquitin ligase complex subunit 3

1

0

High-throughput

0.486

High

752784

NPC1
NPC intracellular sterol transporter 1-related protein 1

1

2

Small-scale

0.481

High

541699

SEC63
Protein translocation protein SEC63

1

2

High-throughput

0.479

High

679901

PMT2
Dolichyl-phosphate-mannose--protein mannosyltransferase 2

1

5

High-throughput

0.479

High

707478

PMT1
Dolichyl-phosphate-mannose--protein mannosyltransferase 1

1

5

High-throughput

0.479

High

728026

YET1
Endoplasmic reticulum transmembrane protein 1

1

5

High-throughput

0.479

High

747314

PHO88
SRP-independent targeting protein 3

1

1

High-throughput

0.479

High

752766

ELO3
Fatty acid elongase 3

1

8

High-throughput

0.479

High

752769

PMT4
Dolichyl-phosphate-mannose--protein mannosyltransferase 4

1

5

High-throughput

0.479

High

752774

ALG9
Alpha-1,2-mannosyltransferase ALG9

1

1

High-throughput

0.479

High

752780

YET3
Endoplasmic reticulum transmembrane protein 3

1

5

High-throughput

0.479

High

752785

PGA3
Plasma membrane-associated coenzyme Q6 reductase PGA3

1

1

High-throughput

0.479

High

520338

HMDH2
3-hydroxy-3-methylglutaryl-coenzyme A reductase 2

1

0

High-throughput

0.458

High

629472

ERG4
Delta(24(24(1)))-sterol reductase ERG4

1

0

High-throughput

0.458

High

707193

SEC66
Translocation protein SEC66

1

0

High-throughput

0.458

High

752760

NSG1
Protein NSG1

1

0

High-throughput

0.458

High

752762

STT3
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3

1

0

High-throughput

0.458

High

752763

SPF1
Endoplasmic reticulum transmembrane helix translocase

1

0

High-throughput

0.458

High

752767

ALG2
Alpha-1,3/1,6-mannosyltransferase ALG2

1

0

High-throughput

0.458

High

752775

PGA2
Processing of GAS1 and ALP protein 2

1

0

High-throughput

0.458

High

520606

YPK1
Serine/threonine-protein kinase YPK1

1

4

Small-scale

0.457

High

752783

YP150
Putative serine/threonine-protein kinase YPL150W

1

1

High-throughput

0.457

High

543674

HSC82
ATP-dependent molecular chaperone HSC82

1

3

High-throughput

0.437

High

493870

HSP72
Heat shock protein SSA2

1

1

High-throughput

0.407

High

676024

XPO1
Exportin-1

1

2

High-throughput

0.407

High

687933

IMB3
Importin subunit beta-3

1

5

High-throughput

0.407

High

704021

PDR5
Pleiotropic ABC efflux transporter of multiple drugs

1

1

High-throughput

0.407

High

752764

GEA2
ARF guanine-nucleotide exchange factor 2

1

2

High-throughput

0.407

High

752765

IMB4
Importin subunit beta-4

1

5

High-throughput

0.407

High

752779

IMB1
Importin subunit beta-1

1

5

High-throughput

0.407

High

751013

RCK1
Serine/threonine-protein kinase RCK1

1

0

High-throughput

0.261

Low

586140

PMA2
Plasma membrane ATPase 2

1

0

High-throughput

0.249

Low

752781

HBT1
Protein HBT1

1

0

High-throughput

0.249

Low

584726

CSK22
Casein kinase II subunit alpha'

1

0

High-throughput

0.238

Low

752759

YHS2
MIP18 family protein YHR122W

1

0

High-throughput

0.238

Low

742652

AAP1
Alanine/arginine aminopeptidase

1

0

High-throughput

0.232

Low

752778

CLU
Clustered mitochondria protein 1

1

0

High-throughput

0.232

Low


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Last updated: 15 Jul 2024