HitPredict - High confidence protein-protein interactions

Protein: SPIKE
Spike glycoprotein (S glycoprotein) (E2) (Peplomer protein) [Cleaved into: Spike protein S1; Spike protein S2; Spike protein S2']

Gene: SPIKE, S
Organism: Severe acute respiratory syndrome-related coronavirus
Interactions: 8
UniProt ID: P59594

Gene Ontology (top 5):
GO:0016020 - membrane
GO:0019031 - viral envelope
GO:0019064 - fusion of virus membrane with host plasma membrane
GO:0020002 - host cell plasma membrane
GO:0039587 - symbiont-mediated-mediated suppression of host tetherin activity

Download interactions: TXT MITAB-2.5

Interaction	Interactor	Experiments	Homologs	Category	Interaction Score	Confidence
947918	SPIKE Spike glycoprotein	30	1	Small-scale	0.992	High
947919	VME1 Membrane protein	3	1	Small-scale	0.660	High
947922	VEMP Envelope small membrane protein	2	1	Small-scale	0.619	High
947921	NS7A ORF7a protein	2	0	Small-scale	0.593	High
947920	AP3A ORF3a protein	1	1	Small-scale	0.479	High
947924	NS8B ORF8b protein	1	0	Small-scale	0.265	Low
947923	NS8A ORF8a protein	1	0	Small-scale	0.249	Low

Service provided by Combinatics, Japan

Last updated: 11Aug2025