HitPredict

Interactor 1: CPSF1 (Q10570)
Cleavage and polyadenylation specificity factor subunit 1 (Cleavage and polyadenylation specificity factor 160 kDa subunit) (CPSF 160 kDa subunit)
Gene: CPSF1

Interactor 2: CUL3 (Q13618)
Cullin-3 (CUL-3)
Gene: CUL3

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	1.00	0.691

Property	Details
Experiments	21145461
Identification Methods	affinity chromatography technology, tandem affinity purification
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	CPSF_A~Cullin, Cullin~MMS1_N
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm
Homologous interactions	18

Homologous interactions

Color coding for hit scores

	1 1443 Hs			1 768
+	Hs
		1014118 CPSF1_HUMAN (1-1443): 0: 1602: 100.00		CUL4A_HUMAN (10-768): 0: 791: 38.32
+	Hs
		1041668 DDB1_HUMAN (738-1438): 2.28e-146: 478: 16.85		CUL3_HUMAN (1-768): 0: 951: 100.00
+	Hs
		1041634 SF3B3_HUMAN (890-1442): 5.69e-137: 454: 15.50		CUL3_HUMAN (1-768): 0: 951: 100.00
+	Mm
		1111812 DDB1_MOUSE (584-1438): 1.41e-146: 479: 15.88		CUL4A_MOUSE (5-768): 0: 796: 37.68
+	Hs
		1043013 DDB1_HUMAN (738-1438): 2.28e-146: 478: 16.85		CUL4A_HUMAN (10-768): 0: 791: 38.32
+	Mm
		56795 DDB1_MOUSE (584-1438): 1.41e-146: 479: 15.88		CUL4B_MOUSE (5-768): 0: 779: 36.64
+	Hs
		1043374 DDB1_HUMAN (738-1438): 2.28e-146: 478: 16.85		CUL4B_HUMAN (5-768): 0: 779: 36.77
+	Hs
		1043002 SF3B3_HUMAN (890-1442): 5.69e-137: 454: 15.50		CUL4A_HUMAN (10-768): 0: 791: 38.32
+	At
		221829 DDB1B_ARATH (1-881): 1.24e-141: 464: 14.39		CUL4_ARATH (8-768): 0: 744: 38.61
+	Dm
		1124382 DDB1_DROME (2-829): 1.54e-131: 437: 14.76		Q5BI50_DROME (5-768): 0: 764: 37.45
+	At
		1228145 DDB1A_ARATH (2-881): 7.73e-137: 451: 14.41		CUL4_ARATH (8-768): 0: 744: 38.61
+	Hs
		1041008 DDB1_HUMAN (738-1438): 2.28e-146: 478: 16.85		CUL1_HUMAN (18-768): 0: 707: 30.57
+	Hs
		1040995 SF3B3_HUMAN (890-1442): 5.69e-137: 454: 15.50		CUL1_HUMAN (18-768): 0: 707: 30.57
+	Hs
		1041332 SF3B3_HUMAN (890-1442): 5.69e-137: 454: 15.50		CUL2_HUMAN (30-768): 0: 672: 26.17
+	Hs
		1082313 DDB1_HUMAN (738-1438): 2.28e-146: 478: 16.85		CUL5_HUMAN (25-768): 0: 597: 23.77
+	Sp
		144468 RIK1_SCHPO (640-1404): 1.08e-102: 355: 13.87		CUL4_SCHPO (7-767): 0: 578: 25.35
+	Sp
		143266 DDB1_SCHPO (3-893): 5.07e-80: 289: 14.46		CUL4_SCHPO (7-767): 0: 578: 25.35
+	Ce
		1088892 DDB1_CAEEL (3-953): 5.15e-78: 284: 14.03		CUL4_CAEEL (12-768): 0: 573: 28.08