HitPredict

Interactor 1: CPSF1 (Q10570)
Cleavage and polyadenylation specificity factor subunit 1 (Cleavage and polyadenylation specificity factor 160 kDa subunit) (CPSF 160 kDa subunit)
Gene: CPSF1

Interactor 2: CUL4A (Q13619)
Cullin-4A (CUL-4A)
Gene: CUL4A

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	37040401
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	CPSF_A~Cullin, Cullin~MMS1_N
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm
Homologous interactions	18

Homologous interactions

Color coding for hit scores

	1 1443 Hs			1 759
+	Hs
		1014117 CPSF1_HUMAN (1-1443): 0: 1602: 100.00		CUL3_HUMAN (32-759): 0: 814: 38.23
+	Mm
		1111812 DDB1_MOUSE (584-1438): 1.41e-146: 479: 15.88		CUL4A_MOUSE (1-759): 0: 977: 95.13
+	Hs
		1043013 DDB1_HUMAN (738-1438): 2.28e-146: 478: 16.85		CUL4A_HUMAN (1-759): 0: 963: 100.00
+	Hs
		1043002 SF3B3_HUMAN (890-1442): 5.69e-137: 454: 15.50		CUL4A_HUMAN (1-759): 0: 963: 100.00
+	Mm
		56795 DDB1_MOUSE (584-1438): 1.41e-146: 479: 15.88		CUL4B_MOUSE (10-759): 0: 927: 82.18
+	Hs
		1043374 DDB1_HUMAN (738-1438): 2.28e-146: 478: 16.85		CUL4B_HUMAN (10-759): 0: 927: 82.31
+	At
		221829 DDB1B_ARATH (1-881): 1.24e-141: 464: 14.39		CUL4_ARATH (24-759): 0: 861: 57.40
+	Dm
		1124382 DDB1_DROME (2-829): 1.54e-131: 437: 14.76		Q5BI50_DROME (27-759): 0: 877: 65.90
+	At
		1228145 DDB1A_ARATH (2-881): 7.73e-137: 451: 14.41		CUL4_ARATH (24-759): 0: 861: 57.40
+	Hs
		1041668 DDB1_HUMAN (738-1438): 2.28e-146: 478: 16.85		CUL3_HUMAN (32-759): 0: 814: 38.23
+	Hs
		1041634 SF3B3_HUMAN (890-1442): 5.69e-137: 454: 15.50		CUL3_HUMAN (32-759): 0: 814: 38.23
+	Hs
		1041008 DDB1_HUMAN (738-1438): 2.28e-146: 478: 16.85		CUL1_HUMAN (59-759): 0: 745: 30.55
+	Hs
		1040995 SF3B3_HUMAN (890-1442): 5.69e-137: 454: 15.50		CUL1_HUMAN (59-759): 0: 745: 30.55
+	Hs
		1041332 SF3B3_HUMAN (890-1442): 5.69e-137: 454: 15.50		CUL2_HUMAN (51-759): 0: 710: 27.00
+	Hs
		1082313 DDB1_HUMAN (738-1438): 2.28e-146: 478: 16.85		CUL5_HUMAN (59-759): 0: 589: 24.94
+	Sp
		144468 RIK1_SCHPO (640-1404): 1.08e-102: 355: 13.87		CUL4_SCHPO (37-755): 0: 638: 31.89
+	Ce
		1088892 DDB1_CAEEL (3-953): 5.15e-78: 284: 14.03		CUL4_CAEEL (10-759): 0: 665: 32.28
+	Sp
		143266 DDB1_SCHPO (3-893): 5.07e-80: 289: 14.46		CUL4_SCHPO (37-755): 0: 638: 31.89