HitPredict

Interactor 1: SCAP (Q12770)
Sterol regulatory element-binding protein cleavage-activating protein (SCAP) (SREBP cleavage-activating protein)
Gene: SCAP

Interactor 2: TBL2 (Q9Y4P3)
Transducin beta-like protein 2 (WS beta-transducin repeats protein) (WS-betaTRP) (Williams-Beuren syndrome chromosomal region 13 protein)
Gene: TBL2

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	1.00	0.691

Property	Details
Experiments	33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	WD40~WD40
Common GO terms	GO:0005783 - endoplasmic reticulum GO:0005789 - endoplasmic reticulum membrane
Homologous interactions	18

Homologous interactions

Color coding for hit scores

	1 1279 Hs			1 447
+	Hs
		168003 NPC1_HUMAN (7-549): 6.42e-121: 408: 20.48		SNR40_HUMAN (258-447): 3.49e-34: 132: 13.02
+	Hs
		168089 NPC1_HUMAN (7-549): 6.42e-121: 408: 20.48		TBL2_HUMAN (308-446): 2.02e-13: 73.6: 12.10
+	Dm
		1358845 WDS_DROME (738-1036): 4.7e-40: 154: 11.58		WDS_DROME (222-447): 4.81e-53: 183: 16.74
+	Hs
		792935 LIS1_HUMAN (641-995): 1.91e-34: 139: 14.36		LIS1_HUMAN (3-218): 5.36e-51: 179: 11.86
+	Mm
		925836 LIS1_MOUSE (641-995): 1.63e-34: 139: 14.36		LIS1_MOUSE (3-218): 3.88e-51: 179: 11.86
+	Hs
		903174 WDR5_HUMAN (752-958): 1.16e-22: 102: 13.91		TBL3_HUMAN (12-447): 1.29e-58: 207: 13.88
+	Hs
		903418 FBXW7_HUMAN (1104-1277): 2.9e-42: 168: 17.14		WDR5_HUMAN (4-165): 6.22e-31: 123: 8.93
+	Hs
		903349 WDR5B_HUMAN (738-1032): 7.65e-40: 153: 11.08		WDR5_HUMAN (4-165): 6.22e-31: 123: 8.93
+	Hs
		792949 LIS1_HUMAN (641-995): 1.91e-34: 139: 14.36		WDR5_HUMAN (4-165): 6.22e-31: 123: 8.93
+	Hs
		929603 FBXW7_HUMAN (1104-1277): 2.9e-42: 168: 17.14		RACK1_HUMAN (266-445): 3.22e-20: 92.7: 16.30
+	Hs
		929730 FBW1A_HUMAN (735-1033): 4.16e-42: 166: 12.90		RACK1_HUMAN (266-445): 3.22e-20: 92.7: 16.30
+	Hs
		903428 WDR5_HUMAN (752-958): 1.16e-22: 102: 13.91		SNR40_HUMAN (258-447): 3.49e-34: 132: 13.02
+	Hs
		792967 LIS1_HUMAN (641-995): 1.91e-34: 139: 14.36		RACK1_HUMAN (266-445): 3.22e-20: 92.7: 16.30
+	Hs
		903077 WDR5_HUMAN (752-958): 1.16e-22: 102: 13.91		WDR5_HUMAN (4-165): 6.22e-31: 123: 8.93
+	Hs
		282843 LIS1_HUMAN (641-995): 1.91e-34: 139: 14.36		CIAO1_HUMAN (81-215): 3.8e-16: 81.1: 18.12
+	Hs
		793026 LIS1_HUMAN (641-995): 1.91e-34: 139: 14.36		KTNB1_HUMAN (187-307): 2.21e-09: 61.6: 30.33
+	Hs
		903109 WDR5_HUMAN (752-958): 1.16e-22: 102: 13.91		RACK1_HUMAN (266-445): 3.22e-20: 92.7: 16.30
+	Hs
		282871 WDR5_HUMAN (752-958): 1.16e-22: 102: 13.91		CIAO1_HUMAN (81-215): 3.8e-16: 81.1: 18.12