HitPredict

Interactor 1: TP53B (Q12888)
TP53-binding protein 1 (53BP1) (p53-binding protein 1) (p53BP1)
Gene: TP53BP1

Interactor 2: SMC5 (Q8IY18)
Structural maintenance of chromosomes protein 5 (SMC protein 5) (SMC-5) (hSMC5)
Gene: SMC5

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.56	0.60	0.584

Property	Details
Experiments	29656893, 36373674
Identification Methods	proximity labelling technology, affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000781 - chromosome, telomeric region GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005737 - cytoplasm GO:0006974 - DNA damage response and 1 others more... GO:0035861 - site of double-strand break
Homologous interactions	8

Homologous interactions

Color coding for hit scores

	1 1972 Hs			1 1101
+	Hs
		1019097 TP53B_HUMAN (1-1972): 0: 766: 100.00		SMC6_HUMAN (9-1069): 7.85e-63: 235: 15.55
+	Hs
		807770 MAP1B_HUMAN (50-1591): 3.52e-51: 202: 9.41		SMC5_HUMAN (1-1101): 5.88e-124: 409: 100.00
+	Hs
		1221669 MINT_HUMAN (2-1787): 6.67e-46: 185: 7.93		SMC5_HUMAN (1-1101): 5.88e-124: 409: 100.00
+	Hs
		1056884 MDC1_HUMAN (10-773): 2.05e-23: 111: 10.33		SMC5_HUMAN (1-1101): 5.88e-124: 409: 100.00
+	Hs
		1221841 SRRM2_HUMAN (18-1418): 1.61e-14: 82.2: 9.78		SMC5_HUMAN (1-1101): 5.88e-124: 409: 100.00
+	Hs
		807858 MAP1B_HUMAN (50-1591): 3.52e-51: 202: 9.41		SMC4_HUMAN (2-1073): 2.02e-73: 268: 12.37
+	Hs
		1056947 MDC1_HUMAN (10-773): 2.05e-23: 111: 10.33		SMC6_HUMAN (9-1069): 7.85e-63: 235: 15.55
+	Hs
		725139 ANK2_HUMAN (3-1685): 1.72e-50: 200: 9.45		MYH10_HUMAN (114-762): 2.31e-22: 106: 10.60