Protein: SPD5
Spindle-defective protein 5

Gene: SPD5, spd-5
Organism: Caenorhabditis elegans
Interactions: 132
UniProt ID: P91349

Gene Ontology (top 5):
GO:0000159 - protein phosphatase type 2A complex
GO:0005737 - cytoplasm
GO:0005813 - centrosome
GO:0007052 - mitotic spindle organization
GO:0007098 - centrosome cycle

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1018997

SPD5
Spindle-defective protein 5

5

17

Small-scale

0.711

High

758745

PLK1
Serine/threonine-protein kinase plk-1

4

7

Small-scale

0.698

High

1018998

SPD2
Spindle-defective protein 2

5

0

Small-scale

0.677

High

145801

P2R31
Serine/threonine-protein phosphatase 2A regulatory subunit rsa-1

2

1

Small-scale

0.611

High

1019059

NLK
Serine/threonine kinase NLK

2

13

High-throughput

0.594

High

112679

ZYG9
Zygote defective protein 9

2

1

Small-scale

0.584

High

111807

G5EDL3
Aurora kinase

2

15

High-throughput

0.576

High

1018836

CSN5
COP9 signalosome complex subunit 5

2

2

High-throughput

0.576

High

113537

RSA2
Regulator of spindle assembly protein 2

2

0

Small-scale

0.541

High

233939

NH111
Nuclear hormone receptor family member nhr-111

1

17

High-throughput

0.494

High

111707

G5EDE7
TPX2 domain-containing protein

1

0

Small-scale

0.480

High

110310

G5EC10
Galectin

1

5

High-throughput

0.479

High

111185

G5ECV9
10-formyltetrahydrofolate dehydrogenase

1

3

High-throughput

0.479

High

146086

MDHM
Malate dehydrogenase, mitochondrial

1

6

High-throughput

0.479

High

195428

O16366
Dynein axonemal light chain 1

1

6

High-throughput

0.479

High

232519

O44490
ELKS/RAB6-interacting/CAST family member 2

1

17

High-throughput

0.479

High

234228

CPL1
Cathepsin L-like

1

5

High-throughput

0.479

High

522558

MYSP
Paramyosin

1

16

High-throughput

0.479

High

536365

HSP6
Heat shock protein hsp-6

1

6

High-throughput

0.479

High

744452

CLAS2
Protein CLASP-2

1

1

High-throughput

0.479

High

939126

SUMO
Small ubiquitin-related modifier

1

1

High-throughput

0.479

High

1019013

IFB2
Intermediate filament protein ifb-2

1

3

High-throughput

0.479

High

1019017

SIP1
Stress-induced protein 1

1

12

High-throughput

0.479

High

1019021

IFC2
Intermediate filament protein ifc-2

1

5

High-throughput

0.479

High

1019024

ANKHM
Ankyrin repeat and KH domain-containing protein mask-1

1

6

High-throughput

0.479

High

1019025

Q22167
EF-hand domain-containing protein

1

10

High-throughput

0.479

High

1019034

Q8MXJ7
Aldehyde dehydrogenase

1

4

High-throughput

0.479

High

1019044

Q9BHK7
5'-3' exoribonuclease 1

1

2

High-throughput

0.479

High

1019045

Q9BI98
BPL/LPL catalytic domain-containing protein

1

1

High-throughput

0.479

High

1019053

Q9TXM1
Uncharacterized protein

1

1

High-throughput

0.479

High

1019057

Q9U2T9
Intersectin-1

1

9

High-throughput

0.479

High

1019058

LIN41
Protein lin-41

1

13

Small-scale

0.479

High

837003

CED9
Apoptosis regulator ced-9

1

0

Small-scale

0.460

High

111871

2AB1
Serine/threonine-protein phosphatase 2A regulatory subunit sur-6

1

0

Small-scale

0.458

High

195882

O17003
Protein MAK10 homolog

1

0

High-throughput

0.458

High

759906

GLH1
ATP-dependent RNA helicase glh-1

1

0

High-throughput

0.458

High

1019015

INX3
Innexin-3

1

0

High-throughput

0.458

High

1019030

Q86G90
Nuclear Pore complex Protein

1

0

High-throughput

0.458

High

1019033

Q8MQ11
Deoxynucleoside kinase domain-containing protein

1

0

High-throughput

0.458

High

1019042

Q95YA9
C-CAP/cofactor C-like domain-containing protein

1

0

High-throughput

0.458

High

72210

A8WI68
Calcium-transporting ATPase

1

3

High-throughput

0.437

High

110980

G5ECM6
Elongation factor Tu, mitochondrial

1

1

High-throughput

0.437

High

111723

G5EDF5
protein-synthesizing GTPase

1

1

High-throughput

0.437

High

112518

G5EEH6
Isovaleryl-CoA dehydrogenase, mitochondrial

1

2

High-throughput

0.437

High

113005

LIN22
Helix-loop-helix protein lin-22

1

3

High-throughput

0.437

High

113520

G5EFS5
B30.2/SPRY domain-containing protein

1

1

High-throughput

0.437

High

115238

H2KYP3
Calx-beta domain-containing protein

1

4

High-throughput

0.437

High

116713

I2HA92
Ubiquitin carboxyl-terminal hydrolase

1

12

High-throughput

0.437

High

144956

SSP1B
FACT complex subunit ssrp1-B

1

5

High-throughput

0.437

High

233360

O44549
Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial

1

2

High-throughput

0.437

High

233367

O44565
Laminin subunit beta-1

1

1

High-throughput

0.437

High

233754

NUCL1
Nucleolin homolog 1

1

7

High-throughput

0.437

High

432254

VIT2
Vitellogenin-2

1

3

High-throughput

0.437

High

438858

VIT5
Vitellogenin-5

1

3

High-throughput

0.437

High

617917

VIT6
Vitellogenin-6

1

3

High-throughput

0.437

High

759633

ECHM
Probable enoyl-CoA hydratase, mitochondrial

1

2

High-throughput

0.437

High

759681

CISY
Probable citrate synthase, mitochondrial

1

1

High-throughput

0.437

High

784914

LEC1
32 kDa beta-galactoside-binding lectin

1

5

High-throughput

0.437

High

857643

AL7A1
Putative aldehyde dehydrogenase family 7 member A1 homolog

1

4

High-throughput

0.437

High

893124

PHB2
Mitochondrial prohibitin complex protein 2

1

7

High-throughput

0.437

High

893457

CH60
Chaperonin homolog Hsp-60, mitochondrial

1

5

High-throughput

0.437

High

913440

MMSA
Probable methylmalonate-semialdehyde/malonate-semialdehyde dehydrogenase [acylating], mitochondrial

1

4

High-throughput

0.437

High

1018450

GPDM
Probable glycerol-3-phosphate dehydrogenase, mitochondrial

1

5

High-throughput

0.437

High

1018996

PWP2
Periodic tryptophan protein 2 homolog

1

8

High-throughput

0.437

High

1018999

GYF1
GYF domain-containing protein gyf-1

1

17

High-throughput

0.437

High

1019001

HMGBH
High mobility group protein 1.2

1

5

High-throughput

0.437

High

1019002

Q09603
Delta(3),Delta(2)-enoyl-CoA isomerase

1

3

High-throughput

0.437

High

1019005

ETFD
Electron transfer flavoprotein-ubiquinone oxidoreductase, mitochondrial

1

1

High-throughput

0.437

High

1019011

RSP6
Probable splicing factor, arginine/serine-rich 6

1

4

High-throughput

0.437

High

1019014

CUT3
Cuticlin-3

1

2

High-throughput

0.437

High

1019016

Q20049
Isocitrate dehydrogenase [NAD] subunit, mitochondrial

1

3

High-throughput

0.437

High

1019019

DPY17
Cuticle collagen dpy-17

1

2

High-throughput

0.437

High

1019020

Q20943
ABC-type glutathione-S-conjugate transporter

1

1

High-throughput

0.437

High

1019022

GABT
Probable 4-aminobutyrate aminotransferase, mitochondrial

1

1

High-throughput

0.437

High

1019026

Q22370
Peptidase M16 N-terminal domain-containing protein

1

1

High-throughput

0.437

High

1019027

Q2L6Y6
Histidine kinase/HSP90-like ATPase domain-containing protein

1

8

High-throughput

0.437

High

1019028

Q7JNG1
Oligomycin sensitivity conferral protein

1

2

High-throughput

0.437

High

1019031

Q86GU3
alanine transaminase

1

1

High-throughput

0.437

High

1019032

Q8MNT7
3-hydroxyisobutyryl-CoA hydrolase, mitochondrial

1

2

High-throughput

0.437

High

1019035

Q8MXS0
Calcium-transporting ATPase

1

2

High-throughput

0.437

High

1019037

IDH3B
Probable isocitrate dehydrogenase [NAD] subunit beta, mitochondrial

1

2

High-throughput

0.437

High

1019039

IDH3A
Probable isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial

1

3

High-throughput

0.437

High

1019040

Q94216
DnaJ homolog subfamily C member 2

1

1

High-throughput

0.437

High

1019043

Q966K5
Nematode cuticle collagen N-terminal domain-containing protein

1

2

High-throughput

0.437

High

1019046

PHB1
Mitochondrial prohibitin complex protein 1

1

6

High-throughput

0.437

High

1019047

Q9GPA4
Trichohyalin

1

19

High-throughput

0.437

High

1019048

RPN1
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1

1

1

High-throughput

0.437

High

1019050

Q9N5T2
AAA domain-containing protein

1

1

High-throughput

0.437

High

1019055

Q9U1Y6
Retinol dehydrogenase 13

1

4

High-throughput

0.437

High

1019060

Q9XUE5
PAN domain protein

1

2

High-throughput

0.437

High

1019061

EFGM
Elongation factor G, mitochondrial

1

2

High-throughput

0.437

High

1019062

F161
Protein fam-161

1

1

High-throughput

0.437

High

1019063

ATPA
ATP synthase subunit alpha, mitochondrial

1

7

High-throughput

0.437

High

145308

O01902
BLOC-1-related complex subunit 5

2

0

High-throughput

0.300

High

63486

SIN3
Paired amphipathic helix protein sin-3

1

0

High-throughput

0.249

Low

91452

C7FZU5
TspO/MBR family protein

1

0

High-throughput

0.249

Low

111107

G5ECS9
Calponin-homology

1

0

High-throughput

0.249

Low

111843

NLTP2
Non-specific lipid-transfer protein-like 2

1

0

High-throughput

0.249

Low

145066

NAT10
RNA cytidine acetyltransferase

1

0

High-throughput

0.249

Low

145116

O01796
LisH domain-containing protein

1

0

High-throughput

0.249

Low

145382

EMR1
Emerin homolog 1

1

0

High-throughput

0.249

Low

145827

O02267
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 7

1

0

High-throughput

0.249

Low

146090

O02642
Succinate--CoA ligase [ADP/GDP-forming] subunit alpha, mitochondrial

1

0

High-throughput

0.249

Low

196025

TOM22
Mitochondrial import receptor subunit TOM22 homolog

1

0

High-throughput

0.249

Low

196144

O17568
Uncharacterized protein

1

0

High-throughput

0.249

Low

196264

O17643
Isocitrate dehydrogenase [NADP]

1

0

High-throughput

0.249

Low

232209

ODPB
Pyruvate dehydrogenase E1 component subunit beta, mitochondrial

1

0

High-throughput

0.249

Low

264026

O62071
PeriCentriolar MatriX Deficient

1

0

High-throughput

0.249

Low

759205

RM44
Large ribosomal subunit protein mL44

1

0

High-throughput

0.249

Low

836741

HCDH2
Probable 3-hydroxyacyl-CoA dehydrogenase B0272.3

1

0

High-throughput

0.249

Low

921414

SUCB2
Succinate--CoA ligase [GDP-forming] subunit beta, mitochondrial

1

0

High-throughput

0.249

Low

1019000

YRS3
Uncharacterized protein mtre-1

1

0

High-throughput

0.249

Low

1019003

Q09979
Hydroxysteroid dehydrogenase-like protein 2

1

0

High-throughput

0.249

Low

1019004

GCP
Bifunctional glyoxylate cycle protein

1

0

High-throughput

0.249

Low

1019006

Q17411
Uncharacterized protein

1

0

High-throughput

0.249

Low

1019007

NU214
Nuclear pore complex protein 14

1

0

High-throughput

0.249

Low

1019008

Q17763
ATP synthase subunit d, mitochondrial

1

0

High-throughput

0.249

Low

1019009

Q18032
Protein sleepless

1

0

High-throughput

0.249

Low

1019010

Q18036
NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9

1

0

High-throughput

0.249

Low

1019012

Q18853
Cytochrome c domain-containing protein

1

0

High-throughput

0.249

Low

1019018

Q20713
Conserved plasma membrane protein

1

0

High-throughput

0.249

Low

1019023

Q21463
Asparagine synthetase [glutamine-hydrolyzing]

1

0

High-throughput

0.249

Low

1019029

Q86D01
Cilia- and flagella-associated protein 157

1

0

High-throughput

0.249

Low

1019036

Q8MXV3
CEntrosomal Protein

1

0

High-throughput

0.249

Low

1019038

Q93540
Mitochondrial glutamate carrier 1

1

0

High-throughput

0.249

Low

1019041

Q95Q55
TraB domain-containing protein

1

0

High-throughput

0.249

Low

1019049

Q9N3H3
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial

1

0

High-throughput

0.249

Low

1019051

Q9NAP4
Clc-like protein

1

0

High-throughput

0.249

Low

1019052

TIM22
Mitochondrial import inner membrane translocase subunit tim-22

1

0

High-throughput

0.249

Low

1019054

PGL1
Guanyl-specific ribonuclease pgl-1

1

0

High-throughput

0.249

Low

1019056

Q9U238
Translocon-associated protein subunit delta

1

0

High-throughput

0.249

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025