HitPredict

Interactor 1: TRAP1 (Q12931)
Heat shock protein 75 kDa, mitochondrial (HSP 75) (Heat shock protein family C member 5) (TNFR-associated protein 1) (Tumor necrosis factor type 1 receptor-associated protein) (TRAP-1)
Gene: TRAP1

Interactor 2: LRRK2 (Q5S007)
Leucine-rich repeat serine/threonine-protein kinase 2 (EC 2.7.11.1) (EC 3.6.5.-) (Dardarin)
Gene: LRRK2

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.33	1.00	0.575

Property	Details
Experiments	24725412
Identification Methods	tandem affinity purification
Interaction Type	association

Property	Details
Interacting Pfam domains	HSP90~Pkinase
Common GO terms	GO:0005524 - ATP binding GO:0005739 - mitochondrion GO:0005743 - mitochondrial inner membrane GO:0005759 - mitochondrial matrix
Homologous interactions	6

Homologous interactions

Color coding for hit scores

	1 704 Hs			1 2527
+	Hs
		3588 A0A140VJY2_HUMAN (1-704): 0: 927: 100.00		LRRK2_HUMAN (1-2527): 0: 3008: 99.72
+	Hs
		538262 ENPL_HUMAN (10-702): 0: 880: 29.24		LRRK2_HUMAN (1-2527): 0: 3008: 99.72
+	Mm
		435923 ENPL_MOUSE (7-702): 0: 876: 29.00		LRRK2_MOUSE (1-2527): 0: 2865: 86.09
+	Hs
		201317 TRAP1_HUMAN (1-704): 0: 927: 100.00		M3K7_HUMAN (1869-2132): 8.36e-23: 107: 28.83
+	Hs
		201198 ENPL_HUMAN (10-702): 0: 880: 29.24		M3K7_HUMAN (1869-2132): 8.36e-23: 107: 28.83
+	Zm
		8229 A0A1D6LMW9_MAIZE (32-702): 0: 783: 28.74		A0A1D6ELX5_MAIZE (1838-2132): 3.79e-24: 113: 30.30