Interactor 1: TRAF2 (Q12933)
TNF receptor-associated factor 2 (EC 2.3.2.27) (E3 ubiquitin-protein ligase TRAF2) (RING-type E3 ubiquitin transferase TRAF2) (Tumor necrosis factor type 2 receptor-associated protein 3)
Gene: TRAF2

Interactor 2: TRAF2 (Q12933)
TNF receptor-associated factor 2 (EC 2.3.2.27) (E3 ubiquitin-protein ligase TRAF2) (RING-type E3 ubiquitin transferase TRAF2) (Tumor necrosis factor type 2 receptor-associated protein 3)
Gene: TRAF2

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.98 1.00 0.991

The method score is based on:

Property Details
Experiments 20447407, 25416956, 23007157, 16189514, 26390021, 30561431, 32296183, 8702708, 10411888, 9020361, 33539883, 34070875, 36185580, 37081115, 12591926, 19810754, 20577214, 15383523, 20385093, 11181075 and 7 others

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Identification Methods x-ray crystallography, two hybrid, enzymatic study, pull down, affinity chromatography technology, fluorescent resonance energy transfer, anti tag coimmunoprecipitation, two hybrid array, virotrap, two hybrid prey pooling approach and 3 others

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Interaction Type association, direct interaction, physical association

The annotation score is based on:

Property Details
Interacting Pfam domains TRAF_BIRC3_bd~TRAF_BIRC3_bd
Common GO terms GO:0000151 - ubiquitin ligase complex
GO:0002637 - regulation of immunoglobulin production
GO:0002726 - positive regulation of T cell cytokine production
GO:0002947 - tumor necrosis factor receptor superfamily complex
GO:0004842 - ubiquitin-protein transferase activity
and 52 others

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Homologous interactions 17

Homologous interactions

Color coding for hit scores

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Hs

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Last updated: 15 Jul 2024