HitPredict

Interactor 1: TRAF2 (Q12933)
TNF receptor-associated factor 2 (EC 2.3.2.27) (E3 ubiquitin-protein ligase TRAF2) (RING-type E3 ubiquitin transferase TRAF2) (Tumor necrosis factor type 2 receptor-associated protein 3)
Gene: TRAF2

Interactor 2: FBXW7 (Q969H0)
F-box/WD repeat-containing protein 7 (Archipelago homolog) (hAgo) (F-box and WD-40 domain-containing protein 7) (F-box protein FBX30) (SEL-10) (hCdc4)
Gene: FBXW7

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.65	0.60	0.628

Property	Details
Experiments	28514442, 33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005654 - nucleoplasm GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0030674 - protein-macromolecule adaptor activity GO:0031625 - ubiquitin protein ligase binding
Homologous interactions	9

Homologous interactions

Color coding for hit scores

	1 501 Hs			1 707
+	Hs
		585027 RO52_HUMAN (28-368): 2.44e-56: 196: 12.68		FBXW7_HUMAN (1-707): 0: 571: 100.00
+	Hs
		135035 TRI38_HUMAN (19-367): 1.53e-53: 189: 14.25		FBXW7_HUMAN (1-707): 0: 571: 100.00
+	Hs
		1052726 TRI25_HUMAN (27-347): 1.26e-39: 153: 12.95		FBXW7_HUMAN (1-707): 0: 571: 100.00
+	Hs
		903186 TRAF3_HUMAN (14-501): 2.21e-112: 345: 31.31		WDR5_HUMAN (570-706): 2.64e-27: 115: 23.02
+	Hs
		903641 TRAF6_HUMAN (2-498): 5.24e-109: 335: 27.08		WDR5_HUMAN (570-706): 2.64e-27: 115: 23.02
+	Hs
		585096 RO52_HUMAN (28-368): 2.44e-56: 196: 12.68		FBW1A_HUMAN (614-705): 2.9e-12: 72: 26.09
+	Hs
		585092 RO52_HUMAN (28-368): 2.44e-56: 196: 12.68		FBW1B_HUMAN (614-705): 7.05e-12: 70.5: 25.00
+	Hs
		1163001 TRAF7_HUMAN (2-357): 6.49e-45: 169: 14.01		TRAF7_HUMAN (492-703): 4.9e-16: 84: 31.34
+	Hs
		1163051 TRAF7_HUMAN (2-357): 6.49e-45: 169: 14.01		FBW1B_HUMAN (614-705): 7.05e-12: 70.5: 25.00