HitPredict

Interactor 1: ANK3 (Q12955)
Ankyrin-3 (ANK-3) (Ankyrin-G)
Gene: ANK3

Interactor 2: RHG22 (Q7Z5H3)
Rho GTPase-activating protein 22 (Rho-type GTPase-activating protein 22)
Gene: ARHGAP22

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.65	0.60	0.628

Property	Details
Experiments	28514442, 33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005829 - cytosol GO:0007165 - signal transduction
Homologous interactions	12

Homologous interactions

Color coding for hit scores

	1 4377 Hs			1 698
+	Hs
		1021414 ANK3_HUMAN (1-4377): 0: 1944: 100.00		RHG21_HUMAN (103-682): 1.32e-83: 291: 18.99
+	Hs
		1021391 ANK3_HUMAN (1-4377): 0: 1944: 100.00		ABR_HUMAN (151-336): 3.03e-20: 97.8: 32.80
+	Hs
		506579 ANK3_HUMAN (1-4377): 0: 1944: 100.00		BCR_HUMAN (151-355): 2.96e-19: 95.1: 32.41
+	Hs
		506657 TNKS2_HUMAN (272-917): 0: 623: 23.86		BCR_HUMAN (151-355): 2.96e-19: 95.1: 32.41
+	Hs
		1133713 ANFY1_HUMAN (270-925): 8.88e-121: 417: 18.16		RHG21_HUMAN (103-682): 1.32e-83: 291: 18.99
+	Hs
		1350006 ANFY1_HUMAN (270-925): 8.88e-121: 417: 18.16		RHG23_HUMAN (71-641): 2.45e-75: 266: 19.76
+	Hs
		993083 ANFY1_HUMAN (270-925): 8.88e-121: 417: 18.16		RHG01_HUMAN (150-356): 1.9e-69: 235: 29.95
+	Hs
		1327797 ANFY1_HUMAN (270-925): 8.88e-121: 417: 18.16		RGAP1_HUMAN (171-348): 1.18e-19: 95.5: 35.68
+	Hs
		957821 ANFY1_HUMAN (270-925): 8.88e-121: 417: 18.16		RHG04_HUMAN (173-354): 4.9e-19: 94: 36.84
+	Mm
		103593 ANK3_MOUSE (3991-4376): 7.67e-34: 147: 40.98		P85A_MOUSE (101-649): 5.31e-76: 260: 15.15
+	Hs
		551050 ANKK1_HUMAN (629-815): 8.74e-20: 99.8: 31.55		CHIN_HUMAN (55-349): 5.43e-76: 253: 20.71
+	Hs
		856146 ANKK1_HUMAN (629-815): 8.74e-20: 99.8: 31.55		CHIO_HUMAN (72-349): 2.56e-73: 246: 22.68