HitPredict

Interactor 1: GNDS (Q12967)
Ral guanine nucleotide dissociation stimulator (RalGDS) (Ral guanine nucleotide exchange factor) (RalGEF)
Gene: RALGDS

Interactor 2: RIT2 (Q99578)
GTP-binding protein Rit2 (EC 3.6.5.2) (Ras-like protein expressed in neurons) (Ras-like without CAAX protein 2)
Gene: RIT2

Species: Homo sapiens

Source: innatedb

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.34	1.00	0.590

Property	Details
Experiments	10545207
Identification Methods	two hybrid
Interaction Type	physical association

Property	Details
Interacting Pfam domains	RA~Ras, Ras~RasGEF, Ras~RasGEF_N
Common GO terms	GO:0005634 - nucleus GO:0005829 - cytosol GO:0005886 - plasma membrane GO:0007265 - Ras protein signal transduction
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 914 Hs			1 217
+	Hs
		897883 GNDS_HUMAN (1-914): 0: 882: 100.00		RAP1B_HUMAN (19-194): 1.7e-82: 244: 46.89
+	Hs
		1021726 GNDS_HUMAN (1-914): 0: 882: 100.00		RIT1_HUMAN (1-217): 2.19e-80: 240: 66.21
+	Hs
		919618 GNDS_HUMAN (1-914): 0: 882: 100.00		RAP1A_HUMAN (19-184): 5.08e-53: 170: 47.90
+	Hs
		905420 GNDS_HUMAN (1-914): 0: 882: 100.00		RRAS2_HUMAN (17-199): 7.08e-51: 165: 52.43
+	Hs
		156094 GNDS_HUMAN (1-914): 0: 882: 100.00		RASM_HUMAN (21-184): 7.76e-48: 157: 52.41
+	Hs
		488070 GNDS_HUMAN (1-914): 0: 882: 100.00		RRAS_HUMAN (33-194): 1.46e-46: 154: 48.81
+	Hs
		349279 GNDS_HUMAN (1-914): 0: 882: 100.00		RASH_HUMAN (20-185): 5e-46: 152: 50.60
+	Hs
		350126 GNDS_HUMAN (1-914): 0: 882: 100.00		RASK_HUMAN (20-183): 3.49e-46: 152: 52.44
+	Mm
		976137 GNDS_MOUSE (61-914): 0: 804: 85.13		RASH_MOUSE (20-185): 5e-46: 152: 50.60
+	Dm
		442968 Q9GR11_DROME (65-887): 7.88e-171: 517: 27.52		RAP1_DROME (19-181): 4.07e-56: 178: 50.31
+	Dm
		442959 Q86BI2_DROME (65-887): 5.66e-170: 515: 27.40		RAP1_DROME (19-181): 4.07e-56: 178: 50.31
+	Dm
		442969 Q9U4U5_DROME (65-887): 4.47e-166: 511: 27.40		RAP1_DROME (19-181): 4.07e-56: 178: 50.31
+	Dm
		443004 Q9GR11_DROME (65-887): 7.88e-171: 517: 27.52		RAS1_DROME (20-203): 2.1e-48: 158: 48.37
+	Dm
		442998 Q86BI2_DROME (65-887): 5.66e-170: 515: 27.40		RAS1_DROME (20-203): 2.1e-48: 158: 48.37
+	Dm
		443005 Q9U4U5_DROME (65-887): 4.47e-166: 511: 27.40		RAS1_DROME (20-203): 2.1e-48: 158: 48.37
+	Hs
		313169 RPGF3_HUMAN (30-680): 3e-125: 403: 15.69		RAP1B_HUMAN (19-194): 1.7e-82: 244: 46.89
+	Hs
		156389 RGRF2_HUMAN (34-651): 2.45e-135: 437: 18.07		RASK_HUMAN (20-183): 3.49e-46: 152: 52.44
+	Hs
		919656 RPGF4_HUMAN (30-650): 4.1e-128: 412: 16.26		RAP1A_HUMAN (19-184): 5.08e-53: 170: 47.90
+	Hs
		313171 RPGF3_HUMAN (30-680): 3e-125: 403: 15.69		RAP1A_HUMAN (19-184): 5.08e-53: 170: 47.90
+	Hs
		349455 GRP3_HUMAN (266-905): 1.14e-132: 415: 15.63		RASH_HUMAN (20-185): 5e-46: 152: 50.60