Protein: THIO
Thioredoxin 1 (Trx-1)

Gene: THIO, trxA
Organism: Escherichia coli K-12
Interactions: 89
UniProt ID: P0AA25

Gene Ontology (top 5):
GO:0005737 - cytoplasm
GO:0005829 - cytosol
GO:0015035 - protein-disulfide reductase activity
GO:0030337 - DNA polymerase processivity factor activity
GO:0045454 - cell redox homeostasis

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

497057

TRXB
Thioredoxin reductase

2

16

Small-scale

0.800

High

495059

TPX
Thiol peroxidase

1

20

Small-scale

0.575

High

497589

STHA
Soluble pyridine nucleotide transhydrogenase

1

9

Small-scale

0.575

High

496416

FTSZ
Cell division protein FtsZ

1

0

Small-scale

0.546

High

497598

PT1P
Phosphoenolpyruvate-dependent phosphotransferase system

1

1

High-throughput

0.541

High

497600

FHUF
Ferric siderophore reductase

1

0

High-throughput

0.518

High

497602

YFHL
Ferredoxin YfhL

1

0

High-throughput

0.518

High

497603

FIXA
Protein FixA

1

2

High-throughput

0.494

High

497604

MBHT
Hydrogenase-2 small chain

1

1

High-throughput

0.494

High

497606

MSRC
Free methionine-R-sulfoxide reductase

1

1

High-throughput

0.479

High

496337

DPO3B
Beta sliding clamp

1

0

High-throughput

0.458

High

361503

SODM
Superoxide dismutase [Mn]

1

1

Small-scale

0.445

High

361587

RIR1
Ribonucleoside-diphosphate reductase 1 subunit alpha

1

1

Small-scale

0.445

High

467671

IDH
Isocitrate dehydrogenase [NADP]

1

4

Small-scale

0.445

High

483703

PUTA
Bifunctional protein PutA [Includes: Proline dehydrogenase

1

5

Small-scale

0.445

High

490138

CH10
Co-chaperonin GroES

1

3

Small-scale

0.445

High

490252

CLPP
ATP-dependent Clp protease proteolytic subunit

1

1

Small-scale

0.445

High

490505

EFG
Elongation factor G

1

9

Small-scale

0.445

High

490585

ENO
Enolase

1

4

Small-scale

0.445

High

491343

HTPG
Chaperone protein HtpG

1

7

Small-scale

0.445

High

491884

NDK
Nucleoside diphosphate kinase

1

5

Small-scale

0.445

High

492286

RECA
Protein RecA

1

1

Small-scale

0.445

High

495039

TPIS
Triosephosphate isomerase

1

3

Small-scale

0.445

High

495121

UBIE
Ubiquinone/menaquinone biosynthesis C-methyltransferase UbiE

1

3

Small-scale

0.445

High

496460

FUR
Ferric uptake regulation protein

1

1

Small-scale

0.445

High

496502

G3P1
Glyceraldehyde-3-phosphate dehydrogenase A

1

9

Small-scale

0.445

High

496749

SLYD
FKBP-type peptidyl-prolyl cis-trans isomerase SlyD

1

1

Small-scale

0.445

High

496852

FKBB
FKBP-type 22 kDa peptidyl-prolyl cis-trans isomerase

1

9

Small-scale

0.445

High

497314

MREB
Cell shape-determining protein MreB

1

8

Small-scale

0.445

High

497373

CSPA
Cold shock protein CspA

1

2

Small-scale

0.445

High

497565

ALF
Fructose-bisphosphate aldolase class 2

1

1

Small-scale

0.445

High

497570

GLMU
Bifunctional protein GlmU [Includes: UDP-N-acetylglucosamine pyrophosphorylase

1

3

Small-scale

0.445

High

497571

DBHB
DNA-binding protein HU-beta

1

1

Small-scale

0.445

High

497573

FABG
3-oxoacyl-[acyl-carrier-protein] reductase FabG

1

2

Small-scale

0.445

High

497574

FABI
Enoyl-[acyl-carrier-protein] reductase [NADH] FabI

1

2

Small-scale

0.445

High

497576

NUSG
Transcription termination/antitermination protein NusG

1

1

Small-scale

0.445

High

497579

RCSB
Transcriptional regulatory protein RcsB

1

2

Small-scale

0.445

High

497581

KATG
Catalase-peroxidase

1

2

Small-scale

0.445

High

497584

KPYK2
Pyruvate kinase II

1

1

Small-scale

0.445

High

497592

GLMM
Phosphoglucosamine mutase

1

4

Small-scale

0.445

High

497593

FDOG
Formate dehydrogenase-O major subunit

1

1

Small-scale

0.445

High

497597

ACNB
Aconitate hydratase B

1

3

Small-scale

0.445

High

497601

OBG
GTPase ObgE/CgtA

1

4

Small-scale

0.445

High

490337

HSLU
ATP-dependent protease ATPase subunit HslU

1

0

Small-scale

0.426

High

490544

EFP
Elongation factor P

1

0

Small-scale

0.426

High

490550

EFTS
Elongation factor Ts

1

0

Small-scale

0.426

High

490640

FABA
3-hydroxydecanoyl-[acyl-carrier-protein] dehydratase

1

0

Small-scale

0.426

High

490670

FABZ
3-hydroxyacyl-[acyl-carrier-protein] dehydratase FabZ

1

0

Small-scale

0.426

High

492228

PYRH
Uridylate kinase

1

0

Small-scale

0.426

High

494661

RPOZ
DNA-directed RNA polymerase subunit omega

1

0

Small-scale

0.426

High

494808

SUCC
Succinate--CoA ligase [ADP-forming] subunit beta

1

0

Small-scale

0.426

High

495016

TNAA
Tryptophanase

1

0

Small-scale

0.426

High

495080

TALB
Transaldolase B

1

0

Small-scale

0.426

High

495299

YAJQ
Nucleotide-binding protein YajQ

1

0

Small-scale

0.426

High

495470

YBED
UPF0250 protein YbeD

1

0

Small-scale

0.426

High

496548

DAPD
2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase

1

0

Small-scale

0.426

High

497253

LPTB
Lipopolysaccharide export system ATP-binding protein LptB

1

0

Small-scale

0.426

High

497557

OMPR
DNA-binding dual transcriptional regulator OmpR

1

0

Small-scale

0.426

High

497568

DKSA
RNA polymerase-binding transcription factor DksA

1

0

Small-scale

0.426

High

497572

YDJA
Putative NAD(P)H nitroreductase YdjA

1

0

Small-scale

0.426

High

497577

SRP54
Signal recognition particle protein

1

0

Small-scale

0.426

High

497578

SUCD
Succinate--CoA ligase [ADP-forming] subunit alpha

1

0

Small-scale

0.426

High

497580

UDP
Uridine phosphorylase

1

0

Small-scale

0.426

High

497585

ADD
Adenosine deaminase

1

0

Small-scale

0.426

High

497586

KITH
Thymidine kinase

1

0

Small-scale

0.426

High

497588

YJIA
Zinc chaperone YjiA

1

0

Small-scale

0.426

High

497595

MQO
Malate:quinone oxidoreductase

1

0

Small-scale

0.426

High

497605

PTGA
PTS system glucose-specific EIIA component

1

0

Small-scale

0.426

High

393943

RBSB
Ribose import binding protein RbsB

1

2

Small-scale

0.407

High

393983

OMPF
Outer membrane porin F

1

1

Small-scale

0.407

High

450033

OMPC
Outer membrane porin C

1

1

Small-scale

0.407

High

497564

MGLA
Galactose/methyl galactoside import ATP-binding protein MglA

1

2

Small-scale

0.407

High

497566

ATPA
ATP synthase subunit alpha

1

9

Small-scale

0.407

High

497567

ATPB
ATP synthase subunit beta

1

8

Small-scale

0.407

High

497569

SDHA
Succinate dehydrogenase flavoprotein subunit

1

5

Small-scale

0.407

High

497583

FADB
Fatty acid oxidation complex subunit alpha [Includes: Enoyl-CoA hydratase/Delta(3)-cis-Delta(2)-trans-enoyl-CoA isomerase/3-hydroxybutyryl-CoA epimerase

1

3

Small-scale

0.407

High

497582

HYCF
Formate hydrogenlyase subunit 6

1

0

High-throughput

0.282

High

497596

WBBL
Rhamnosyltransferase WbbL

1

0

High-throughput

0.238

Low

365950

BGAL
Beta-galactosidase

1

0

Small-scale

0.232

Low

394002

LAMB
Maltoporin

1

0

Small-scale

0.232

Low

495235

NRDR
Transcriptional repressor NrdR

1

0

Small-scale

0.232

Low

496090

OMPA
Outer membrane protein A

1

0

Small-scale

0.232

Low

497575

MALE
Maltose/maltodextrin-binding periplasmic protein

1

0

Small-scale

0.232

Low

497587

PRC
Tail-specific protease

1

0

Small-scale

0.232

Low

497590

NRDD
Anaerobic ribonucleoside-triphosphate reductase

1

0

Small-scale

0.232

Low

497591

SDHM
L-serine dehydratase 2

1

0

Small-scale

0.232

Low

497594

YEBE
Inner membrane protein YebE

1

0

Small-scale

0.232

Low

497599

AG43
Antigen 43

1

0

Small-scale

0.232

Low

497607

YQAB
Fructose-1-phosphate phosphatase YqaB

1

0

Small-scale

0.232

Low


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Last updated: 11Aug2025