HitPredict

Interactor 1: GRIK2 (Q13002)
Glutamate receptor ionotropic, kainate 2 (GluK2) (Excitatory amino acid receptor 4) (EAA4) (Glutamate receptor 6) (GluR-6) (GluR6)
Gene: GRIK2

Interactor 2: PICK1 (Q9NRD5)
PRKCA-binding protein (Protein interacting with C kinase 1) (Protein kinase C-alpha-binding protein)
Gene: PICK1

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.66	0.60	0.631

Property	Details
Experiments	12597860, 18692513
Identification Methods	pull down, affinity chromatography technology, two hybrid
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005886 - plasma membrane GO:0042734 - presynaptic membrane GO:0043113 - receptor clustering
Homologous interactions	11

Homologous interactions

Color coding for hit scores

	1 908 Hs			1 415
+	Rn
		786686 GRIK2_RAT (1-908): 0: 961: 99.12		PICK1_RAT (1-415): 0: 597: 96.39
+	Rn
		611607 GRIK1_RAT (14-890): 0: 873: 76.68		PICK1_RAT (1-415): 0: 597: 96.39
+	Hs
		761212 GRIK1_HUMAN (14-854): 0: 874: 80.26		PICK1_HUMAN (1-415): 0: 592: 100.00
+	Rn
		585195 GRIA3_RAT (8-863): 0: 761: 38.91		PICK1_RAT (1-415): 0: 597: 96.39
+	Hs
		786764 GRIA3_HUMAN (8-863): 0: 764: 39.02		PICK1_HUMAN (1-415): 0: 592: 100.00
+	Hs
		786710 GRIA1_HUMAN (15-854): 0: 763: 39.46		PICK1_HUMAN (1-415): 0: 592: 100.00
+	Rn
		585217 GRIA4_RAT (12-887): 0: 755: 37.28		PICK1_RAT (1-415): 0: 597: 96.39
+	Hs
		816226 GRIA4_HUMAN (12-887): 0: 756: 37.39		PICK1_HUMAN (1-415): 0: 592: 100.00
+	Rn
		585182 GRIA2_RAT (13-863): 0: 743: 38.22		PICK1_RAT (1-415): 0: 597: 96.39
+	Hs
		786746 GRIA2_HUMAN (13-863): 0: 746: 38.33		PICK1_HUMAN (1-415): 0: 592: 100.00
+	Mm
		620964 GRIA2_MOUSE (13-863): 0: 743: 38.22		PICK1_MOUSE (1-415): 0: 584: 94.47