HitPredict

Interactor 1: STK4 (Q13043)
Serine/threonine-protein kinase 4 (EC 2.7.11.1) (Mammalian STE20-like protein kinase 1) (MST-1) (STE20-like kinase MST1) (Serine/threonine-protein kinase Krs-2) [Cleaved into: Serine/threonine-protein kinase 4 37kDa subunit (MST1/N); Serine/threonine-protein kinase 4 18kDa subunit (MST1/C)]
Gene: STK4

Interactor 2: RASF1 (Q9NS23)
Ras association domain-containing protein 1
Gene: RASSF1

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.97	1.00	0.987

Property	Details
Experiments	26186194, 24366813, 28514442, 28205554, 33961781, 17598981, 26578655, 24981860, 35271311, 36736316, 20562859, 24255178, 23455922, 14729613, 23386615, 20920251, 15109305
Identification Methods	affinity chromatography technology, fluorescent resonance energy transfer, two hybrid, proximity labelling technology, anti tag coimmunoprecipitation, tandem affinity purification, coimmunoprecipitation
Interaction Type	physical association, direct interaction, association

Property	Details
Interacting Pfam domains	Mst1_SARAH~Nore1-SARAH, C1_1~Pkinase, Nore1-SARAH~Pkinase
Common GO terms	GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0050821 - protein stabilization
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 487 Hs			1 344
+	Hs
		1027444 STK3_HUMAN (1-487): 2.36e-147: 432: 72.47		RASF1_HUMAN (1-344): 7.96e-150: 427: 100.00
+	Mm
		1125492 STK4_MOUSE (1-487): 3.54e-168: 484: 97.33		RASF5_MOUSE (11-339): 1.14e-116: 345: 44.81
+	Hs
		1023084 STK4_HUMAN (1-487): 7.89e-170: 489: 100.00		RASF5_HUMAN (11-339): 8.08e-111: 330: 43.23
+	Hs
		1027406 STK3_HUMAN (1-487): 2.36e-147: 432: 72.47		RASF5_HUMAN (11-339): 8.08e-111: 330: 43.23
+	Hs
		841548 STK4_HUMAN (1-487): 7.89e-170: 489: 100.00		RASF2_HUMAN (122-339): 1.48e-67: 217: 23.61
+	Hs
		1023066 STK4_HUMAN (1-487): 7.89e-170: 489: 100.00		RASF6_HUMAN (134-339): 1.28e-65: 213: 22.73
+	Hs
		1023077 STK4_HUMAN (1-487): 7.89e-170: 489: 100.00		RASF3_HUMAN (118-339): 2.62e-59: 192: 44.44
+	Hs
		1023109 STK4_HUMAN (1-487): 7.89e-170: 489: 100.00		RASF4_HUMAN (117-339): 4.8e-51: 173: 24.17
+	Hs
		841549 STK3_HUMAN (1-487): 2.36e-147: 432: 72.47		RASF2_HUMAN (122-339): 1.48e-67: 217: 23.61
+	Hs
		1027388 STK3_HUMAN (1-487): 2.36e-147: 432: 72.47		RASF6_HUMAN (134-339): 1.28e-65: 213: 22.73
+	Hs
		1027396 STK3_HUMAN (1-487): 2.36e-147: 432: 72.47		RASF3_HUMAN (118-339): 2.62e-59: 192: 44.44
+	Hs
		1027429 STK3_HUMAN (1-487): 2.36e-147: 432: 72.47		RASF4_HUMAN (117-339): 4.8e-51: 173: 24.17
+	Hs
		682169 AKT2_HUMAN (3-353): 1.95e-134: 398: 21.88		KPCZ_HUMAN (15-152): 6.03e-34: 133: 24.11
+	Mm
		682107 AKT1_MOUSE (3-350): 2.1e-132: 393: 20.89		KPCZ_MOUSE (15-152): 4.36e-33: 131: 24.11
+	Hs
		616701 KS6B1_HUMAN (20-440): 2.22e-130: 390: 20.68		KPCZ_HUMAN (15-152): 6.03e-34: 133: 24.11
+	Hs
		983943 AKT3_HUMAN (2-330): 8.44e-131: 389: 21.68		KPCZ_HUMAN (15-152): 6.03e-34: 133: 24.11
+	Hs
		1068473 MARK2_HUMAN (6-486): 9.18e-123: 378: 20.68		KPCD1_HUMAN (50-183): 2.44e-19: 91: 19.40
+	Mm
		554867 AKT1_MOUSE (3-350): 2.1e-132: 393: 20.89		KPCE_MOUSE (27-107): 4.01e-13: 72.2: 31.33
+	Hs
		969093 MARK2_HUMAN (6-486): 9.18e-123: 378: 20.68		KPCE_HUMAN (27-107): 4.59e-13: 72.2: 31.33
+	Hs
		647878 MARK3_HUMAN (29-451): 4.09e-123: 378: 21.32		KPCT_HUMAN (30-114): 9.76e-11: 64.9: 27.06