HitPredict

Interactor 1: TRAF1 (Q13077)
TNF receptor-associated factor 1 (Epstein-Barr virus-induced protein 6)
Gene: TRAF1

Interactor 2: TRAIP (Q9BWF2)
E3 ubiquitin-protein ligase TRAIP (EC 2.3.2.27) (RING finger protein 206) (TRAF-interacting protein)
Gene: TRAIP

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.61	0.60	0.606

Property	Details
Experiments	9104814, 17544371
Identification Methods	two hybrid, pull down, affinity chromatography technology
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0006915 - apoptotic process
Homologous interactions	13

Homologous interactions

Color coding for hit scores

	1 416 Hs			1 469
+	Hs
		1020906 TRAF2_HUMAN (3-415): 4e-124: 370: 38.01		TRAIP_HUMAN (1-469): 1.32e-114: 346: 100.00
+	Mm
		761832 TRAF2_MOUSE (3-415): 3.91e-127: 378: 37.77		TRAIP_MOUSE (1-467): 1.17e-109: 334: 79.70
+	Hs
		1314608 TRAF6_HUMAN (15-414): 1.57e-103: 318: 22.98		TRAIP_HUMAN (1-469): 1.32e-114: 346: 100.00
+	Mm
		936267 TRAF6_MOUSE (15-414): 1.94e-101: 313: 22.51		TRAIP_MOUSE (1-467): 1.17e-109: 334: 79.70
+	Hs
		787905 TRAF2_HUMAN (3-415): 4e-124: 370: 38.01		EPS15_HUMAN (3-170): 2.69e-10: 64.9: 14.53
+	Hs
		728474 TRAF2_HUMAN (3-415): 4e-124: 370: 38.01		MYH11_HUMAN (29-307): 1.74e-09: 62.5: 17.07
+	Hs
		129594 TRAF5_HUMAN (14-261): 1.36e-16: 83.8: 13.91		TRAIP_HUMAN (1-469): 1.32e-114: 346: 100.00
+	Hs
		1024752 TRAF3_HUMAN (3-262): 9.64e-11: 65.3: 15.77		TRAIP_HUMAN (1-469): 1.32e-114: 346: 100.00
+	Dm
		1179373 Q960H6_DROME (32-412): 5.95e-90: 281: 21.48		Q7K2X1_DROME (7-294): 2.71e-30: 123: 23.65
+	Dm
		1179391 Q9VXG5_DROME (50-412): 4.98e-85: 266: 21.20		Q7K2X1_DROME (7-294): 2.71e-30: 123: 23.65
+	Hs
		725088 TRAF6_HUMAN (15-414): 1.57e-103: 318: 22.98		MYH9_HUMAN (41-307): 2.24e-09: 62.1: 14.47
+	Mm
		1141401 TRAF3_MOUSE (1-262): 2.34e-12: 70.7: 16.37		EP15R_MOUSE (12-185): 1.5e-09: 62.6: 8.62
+	Hs
		724993 TRAF4_HUMAN (27-136): 3.55e-09: 60.3: 17.86		MYH9_HUMAN (41-307): 2.24e-09: 62.1: 14.47