Protein: DDR1
Epithelial discoidin domain-containing receptor 1 (Epithelial discoidin domain receptor 1) (EC 2.7.10.1) (CD167 antigen-like family member A) (Cell adhesion kinase) (Discoidin receptor tyrosine kinase) (HGK2) (Mammary carcinoma kinase 10) (MCK-10) (Protein-tyrosine kinase 3A) (Protein-tyrosine kinase RTK-6) (TRK E) (Tyrosine kinase DDR) (Tyrosine-protein kinase CAK) (CD antigen CD167a)

Gene: DDR1
Organism: Homo sapiens
Interactions: 158
UniProt ID: Q08345

Gene Ontology (top 5):
GO:0001558 - regulation of cell growth
GO:0001952 - regulation of cell-matrix adhesion
GO:0004714 - transmembrane receptor protein tyrosine kinase activity
GO:0005518 - collagen binding
GO:0005524 - ATP binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

994642

DDR2
Discoidin domain-containing receptor 2

2

20

High-throughput

0.811

High

666088

SHC1
SHC-transforming protein 1

2

20

Small-scale

0.777

High

665223

EPHA2
Ephrin type-A receptor 2

2

20

Small-scale

0.776

High

209040

NCK2
Cytoplasmic protein NCK2

2

20

Small-scale

0.769

High

994629

DDR1
Epithelial discoidin domain-containing receptor 1

2

19

Small-scale

0.755

High

655337

P85A
Phosphatidylinositol 3-kinase regulatory subunit alpha

2

20

Small-scale

0.737

High

985944

PTN11
Tyrosine-protein phosphatase non-receptor type 11

2

20

Small-scale

0.706

High

537735

INSRR
Insulin receptor-related protein

1

17

High-throughput

0.691

High

739960

TGFR2
TGF-beta receptor type-2

1

19

High-throughput

0.691

High

943109

KC1G2
Casein kinase I isoform gamma-2

1

17

High-throughput

0.691

High

964103

CD83
CD83 antigen

1

2

High-throughput

0.691

High

994630

AVR2B
Activin receptor type-2B

1

20

High-throughput

0.691

High

994686

FLRT1
Leucine-rich repeat transmembrane protein FLRT1

1

20

High-throughput

0.691

High

994639

CDC37
Hsp90 co-chaperone Cdc37

4

19

Small-scale

0.691

High

129284

P85B
Phosphatidylinositol 3-kinase regulatory subunit beta

2

20

Small-scale

0.659

High

994641

MK06
Mitogen-activated protein kinase 6

1

20

High-throughput

0.656

High

994646

TIGIT
T-cell immunoreceptor with Ig and ITIM domains

1

0

High-throughput

0.656

High

724539

IRS1
Insulin receptor substrate 1

1

20

Small-scale

0.647

High

154350

TR10B
Tumor necrosis factor receptor superfamily member 10B

2

17

High-throughput

0.628

High

433332

YES
Tyrosine-protein kinase Yes

1

19

Small-scale

0.625

High

383766

ERBB2
Receptor tyrosine-protein kinase erbB-2

1

20

Small-scale

0.621

High

782027

RGS2
Regulator of G-protein signaling 2

2

3

High-throughput

0.620

High

994644

CEA21
Carcinoembryonic antigen-related cell adhesion molecule 21

1

10

High-throughput

0.618

High

994692

VSIG4
V-set and immunoglobulin domain-containing protein 4

1

16

High-throughput

0.618

High

994652

TRI67
Tripartite motif-containing protein 67

1

14

High-throughput

0.618

High

506576

BCR
Breakpoint cluster region protein

2

20

High-throughput

0.611

High

994633

FLOT2
Flotillin-2

2

15

High-throughput

0.611

High

994688

UBQL2
Ubiquilin-2

2

9

High-throughput

0.606

High

176438

SHIP2
Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2

1

19

Small-scale

0.575

High

412153

FYN
Tyrosine-protein kinase Fyn

1

20

Small-scale

0.575

High

433722

LYN
Tyrosine-protein kinase Lyn

1

20

Small-scale

0.575

High

522939

SRC
Proto-oncogene tyrosine-protein kinase Src

1

19

Small-scale

0.575

High

547024

EZRI
Ezrin

1

20

Small-scale

0.575

High

557671

NCK1
SH2/SH3 adapter protein NCK1

1

20

Small-scale

0.575

High

580989

PLCG1
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1

1

20

Small-scale

0.575

High

596396

RASA1
Ras GTPase-activating protein 1

1

20

Small-scale

0.575

High

719462

MERL
Merlin

1

20

Small-scale

0.575

High

776663

STAT3
Signal transducer and activator of transcription 3

1

19

Small-scale

0.575

High

782782

CSK
Tyrosine-protein kinase CSK

1

20

Small-scale

0.575

High

802578

CRK
Adapter molecule crk

1

20

Small-scale

0.575

High

849885

STA5B
Signal transducer and activator of transcription 5B

1

19

Small-scale

0.575

High

855789

VAV2
Guanine nucleotide exchange factor VAV2

1

20

Small-scale

0.575

High

924517

GRB2
Growth factor receptor-bound protein 2

1

20

Small-scale

0.575

High

994634

FLNC
Filamin-C

1

16

Small-scale

0.575

High

994661

UBS3B
Ubiquitin-associated and SH3 domain-containing protein B

1

20

Small-scale

0.575

High

994665

SHIP1
Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1

1

20

Small-scale

0.575

High

994689

VAV3
Guanine nucleotide exchange factor VAV3

1

20

Small-scale

0.575

High

994694

TLN1
Talin-1

1

20

Small-scale

0.575

High

804219

NOTC1
Neurogenic locus notch homolog protein 1

1

16

Small-scale

0.561

High

118724

AIP
AH receptor-interacting protein

1

16

High-throughput

0.553

High

62564

TCAF2
TRPM8 channel-associated factor 2

1

1

High-throughput

0.536

High

132256

DLL1
Delta-like protein 1

1

10

High-throughput

0.536

High

156823

FFAR1
Free fatty acid receptor 1

1

12

High-throughput

0.536

High

212287

ITM2A
Integral membrane protein 2A

1

3

High-throughput

0.536

High

326059

TSN15
Tetraspanin-15

1

7

High-throughput

0.536

High

587343

ITIH2
Inter-alpha-trypsin inhibitor heavy chain H2

1

4

High-throughput

0.536

High

946013

DLK1
Protein delta homolog 1

1

14

High-throughput

0.536

High

957825

EFNB1
Ephrin-B1

1

2

High-throughput

0.536

High

994631

KCNC3
Potassium voltage-gated channel subfamily C member 3

1

7

High-throughput

0.536

High

994654

T150A
Transmembrane protein 150A

1

1

High-throughput

0.536

High

994655

TSN33
Tetraspanin-33

1

8

High-throughput

0.536

High

994658

IZUM1
Izumo sperm-egg fusion protein 1

1

2

High-throughput

0.536

High

994667

TR19L
Tumor necrosis factor receptor superfamily member 19L

1

3

High-throughput

0.536

High

994669

TSN17
Tetraspanin-17

1

8

High-throughput

0.536

High

994670

MRAP2
Melanocortin-2 receptor accessory protein 2

1

2

High-throughput

0.536

High

994673

OPALI
Opalin

1

1

High-throughput

0.536

High

994675

SYT11
Synaptotagmin-11

1

8

High-throughput

0.536

High

994676

PCDC1
Protocadherin alpha-C1

1

13

High-throughput

0.536

High

994684

GPR83
G-protein coupled receptor 83

1

6

High-throughput

0.536

High

994693

RNF11
RING finger protein 11

1

9

High-throughput

0.536

High

994695

PCDA9
Protocadherin alpha-9

1

9

High-throughput

0.536

High

994696

PCDA8
Protocadherin alpha-8

1

9

High-throughput

0.536

High

994697

KCNE3
Potassium voltage-gated channel subfamily E member 3

1

3

High-throughput

0.536

High

363588

TTHY
Transthyretin

1

0

High-throughput

0.518

High

673746

T4S1
Transmembrane 4 L6 family member 1

1

0

High-throughput

0.518

High

786329

STAT1
Signal transducer and activator of transcription 1-alpha/beta

1

19

Small-scale

0.514

High

994664

P55G
Phosphatidylinositol 3-kinase regulatory subunit gamma

1

20

Small-scale

0.514

High

131893

UPK2
Uroplakin-2

1

0

High-throughput

0.513

High

179167

COPT1
High affinity copper uptake protein 1

1

0

High-throughput

0.513

High

702342

TNFL8
Tumor necrosis factor ligand superfamily member 8

1

0

High-throughput

0.513

High

358504

CO1A1
Collagen alpha-1(I) chain

1

7

Small-scale

0.501

High

358635

CO3A1

1

7

Small-scale

0.501

High

436030

CO1A2
Collagen alpha-2(I) chain

1

7

Small-scale

0.501

High

994668

SNR40
U5 small nuclear ribonucleoprotein 40 kDa protein

1

8

High-throughput

0.494

High

994656

T200A
Transmembrane protein 200A

1

1

High-throughput

0.489

High

994662

KCNE4
Potassium voltage-gated channel subfamily E member 4

1

1

High-throughput

0.489

High

994677

TM231
Transmembrane protein 231

1

1

High-throughput

0.489

High

994678

MANS1
MANSC domain-containing protein 1

1

2

High-throughput

0.489

High

994685

WWOX
WW domain-containing oxidoreductase

1

1

High-throughput

0.489

High

260856

H2AY
Core histone macro-H2A.1

1

6

High-throughput

0.479

High

397354

ADT2
ADP/ATP translocase 2

1

11

High-throughput

0.479

High

431779

HS90A
Heat shock protein HSP 90-alpha

1

20

High-throughput

0.479

High

500782

CLUS
Clusterin

1

5

High-throughput

0.479

High

521890

CADH1
Cadherin-1

1

20

Small-scale

0.479

High

580228

CADH2
Cadherin-2

1

20

Small-scale

0.479

High

708426

MCM4
DNA replication licensing factor MCM4

1

7

Small-scale

0.479

High

874218

DRG2
Developmentally-regulated GTP-binding protein 2

1

4

Small-scale

0.479

High

896422

UBE2N
Ubiquitin-conjugating enzyme E2 N

1

8

High-throughput

0.479

High

994638

MSMO1
Methylsterol monooxygenase 1

1

2

High-throughput

0.479

High

994647

ZN326
DBIRD complex subunit ZNF326

1

4

High-throughput

0.479

High

994648

F1711
Protein FAM171A1

1

18

High-throughput

0.479

High

994657

AHNK2
Protein AHNAK2

1

5

High-throughput

0.479

High

994666

RAD50
DNA repair protein RAD50

1

16

Small-scale

0.479

High

994671

DDX27
Probable ATP-dependent RNA helicase DDX27

1

14

High-throughput

0.479

High

994679

CYBP
Calcyclin-binding protein

1

3

High-throughput

0.479

High

994681

GOPC
Golgi-associated PDZ and coiled-coil motif-containing protein

1

20

High-throughput

0.479

High

994687

CHRD1
Cysteine and histidine-rich domain-containing protein 1

1

5

High-throughput

0.479

High

994690

RAB21
Ras-related protein Rab-21

1

20

High-throughput

0.479

High

126195

PK3CD
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform

1

20

Small-scale

0.445

High

217255

ORC5
Origin recognition complex subunit 5

1

1

Small-scale

0.445

High

262800

CISY
Citrate synthase, mitochondrial

1

2

Small-scale

0.445

High

364255

TFR1
Transferrin receptor protein 1

1

7

Small-scale

0.445

High

430151

PROF1
Profilin-1

1

1

Small-scale

0.445

High

536622

FPPS
Farnesyl pyrophosphate synthase

1

2

Small-scale

0.445

High

598700

ACOHC
Cytoplasmic aconitate hydratase

1

2

Small-scale

0.445

High

787218

PK3CA
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform

1

20

Small-scale

0.445

High

787369

PK3CB
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform

1

20

Small-scale

0.445

High

946230

BASP1
Brain acid soluble protein 1

1

2

Small-scale

0.445

High

984566

CALD1
Caldesmon

1

20

Small-scale

0.445

High

994635

NOLC1
Nucleolar and coiled-body phosphoprotein 1

1

4

Small-scale

0.445

High

994637

PCH2
Pachytene checkpoint protein 2 homolog

1

13

Small-scale

0.445

High

994663

PALLD
Palladin

1

20

Small-scale

0.445

High

994672

ITCH
E3 ubiquitin-protein ligase Itchy homolog

1

14

Small-scale

0.445

High

994691

VDAC3
Voltage-dependent anion-selective channel protein 3

1

8

Small-scale

0.445

High

173380

ACOX3
Peroxisomal acyl-coenzyme A oxidase 3

1

5

High-throughput

0.437

High

315550

SC24A
Protein transport protein Sec24A

1

20

High-throughput

0.437

High

315690

SC24B
Protein transport protein Sec24B

1

20

High-throughput

0.437

High

894933

SRP54
Signal recognition particle subunit SRP54

1

13

Small-scale

0.437

High

952798

FOXK1
Forkhead box protein K1

1

4

High-throughput

0.437

High

994649

VIR
Protein virilizer homolog

1

1

High-throughput

0.437

High

994650

PDXD1
Pyridoxal-dependent decarboxylase domain-containing protein 1

1

7

High-throughput

0.437

High

994674

CDCA3
Cell division cycle-associated protein 3

1

9

High-throughput

0.437

High

278982

O75942
Major prion protein

1

0

Small-scale

0.426

High

307802

ZRAB2
Zinc finger Ran-binding domain-containing protein 2

1

0

Small-scale

0.426

High

337012

PNPH
Purine nucleoside phosphorylase

1

0

Small-scale

0.426

High

380181

THY1
Thy-1 membrane glycoprotein

1

0

Small-scale

0.426

High

599792

5NTD
5'-nucleotidase

1

0

Small-scale

0.426

High

72980

B4DRL5
cDNA FLJ60834, highly similar to Engulfment and cell motility protein 2

1

1

Small-scale

0.407

High

631410

BRD2
Bromodomain-containing protein 2

1

7

Small-scale

0.407

High

799978

VDAC2
Voltage-dependent anion-selective channel protein 2

1

8

Small-scale

0.407

High

801683

RAGP1
Ran GTPase-activating protein 1

1

20

Small-scale

0.407

High

876768

NP1L1
Nucleosome assembly protein 1-like 1

1

3

Small-scale

0.407

High

994632

DCTN1
Dynactin subunit 1

1

10

Small-scale

0.407

High

994636

BRD3
Bromodomain-containing protein 3

1

7

Small-scale

0.407

High

994643

MIC60
MICOS complex subunit MIC60

1

3

Small-scale

0.407

High

310935

SNAPN
SNARE-associated protein Snapin

1

0

High-throughput

0.282

High

49205

SHSA3
Protein shisa-3 homolog

1

0

High-throughput

0.279

Low

994640

SGCA
Alpha-sarcoglycan

1

0

High-throughput

0.279

Low

994645

SHSL1
Protein shisa-like-1

1

0

High-throughput

0.279

Low

994651

CP054
Transmembrane protein C16orf54

1

0

High-throughput

0.279

Low

994659

LSME2
Leucine-rich single-pass membrane protein 2

1

0

High-throughput

0.279

Low

994660

MYCT1
Myc target protein 1

1

0

High-throughput

0.279

Low

994680

SACA1
Sperm acrosome membrane-associated protein 1

1

0

High-throughput

0.279

Low

994682

EVA1B
Protein eva-1 homolog B

1

0

High-throughput

0.279

Low

994683

CLDN1
Claudin domain-containing protein 1

1

0

High-throughput

0.279

Low

329102

NUDT3
Diphosphoinositol polyphosphate phosphohydrolase 1

1

0

High-throughput

0.265

Low

994653

BEND5
BEN domain-containing protein 5

1

0

High-throughput

0.238

Low


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Last updated: 15 Jul 2024