HitPredict

Interactor 1: CSN1 (Q13098)
COP9 signalosome complex subunit 1 (SGN1) (Signalosome subunit 1) (G protein pathway suppressor 1) (GPS-1) (JAB1-containing signalosome subunit 1) (Protein MFH)
Gene: GPS1

Interactor 2: CSN4 (Q9BT78)
COP9 signalosome complex subunit 4 (SGN4) (Signalosome subunit 4) (JAB1-containing signalosome subunit 4)
Gene: COPS4

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.88 1.00 0.940

The method score is based on:

Property Details
Experiments 32034103, 19295130, 33961781, 22414063, 11114242, 25043011
Identification Methods pull down, affinity chromatography technology, two hybrid, anti tag coimmunoprecipitation
Interaction Type direct interaction, physical association, association

The annotation score is based on:

Property Details
Interacting Pfam domains CSN4_RPN5_eIF3a~PCI, PCI~PCI, PCI~RPN7
Common GO terms GO:0000338 - protein deneddylation
GO:0005634 - nucleus
GO:0005654 - nucleoplasm
GO:0005737 - cytoplasm
GO:0005829 - cytosol
and 3 others

more...
Homologous interactions 19

Homologous interactions

Color coding for hit scores

1 491
Hs

1 406
+ Mm
+ Mm
+ Hs
+ At
+ Dm
+ Dm
+ Hs
+ Hs
+ Ce
+ At
+ An
+ Ce
+ Dm
+ Hs
+ An
+ Sc
+ Sc
+ Dm
+ Sp

Service provided by Combinatics, Japan

Last updated: 15 Jul 2024