Protein: UBF1
Nucleolar transcription factor 1 (Autoantigen NOR-90) (Upstream-binding factor 1) (UBF-1)

Gene: UBF1, UBTF
Organism: Homo sapiens
Interactions: 225
UniProt ID: P17480

Gene Ontology (top 5):
GO:0001164 - RNA polymerase I core promoter sequence-specific DNA binding
GO:0001165 - RNA polymerase I cis-regulatory region sequence-specific DNA binding
GO:0001181 - RNA polymerase I general transcription initiation factor activity
GO:0001650 - fibrillar center
GO:0003682 - chromatin binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

604622

GDS1
Rap1 GTPase-GDP dissociation stimulator 1

3

0

High-throughput

0.811

High

371097

MYC
Myc proto-oncogene protein

5

19

High-throughput

0.699

High

604745

TF7L2
Transcription factor 7-like 2

1

20

High-throughput

0.691

High

604747

SIR7
NAD-dependent protein deacetylase sirtuin-7

4

5

Small-scale

0.680

High

158549

CTDS2
Carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 2

3

3

High-throughput

0.667

High

442577

RB
Retinoblastoma-associated protein

2

3

Small-scale

0.653

High

604655

RUNX2
Runt-related transcription factor 2

3

9

Small-scale

0.646

High

259400

BRD4
Bromodomain-containing protein 4

3

20

High-throughput

0.640

High

339931

RPA1
DNA-directed RNA polymerase I subunit RPA1

3

4

Small-scale

0.640

High

604662

CHD4
Chromodomain-helicase-DNA-binding protein 4

3

20

Small-scale

0.640

High

604710

EDA
Ectodysplasin-A

4

3

High-throughput

0.630

High

139474

PESC
Pescadillo homolog

2

1

High-throughput

0.628

High

521527

H14
Histone H1.4

2

7

High-throughput

0.628

High

604617

PI42A
Phosphatidylinositol 5-phosphate 4-kinase type-2 alpha

2

2

High-throughput

0.628

High

604711

KAT5
Histone acetyltransferase KAT5

2

1

Small-scale

0.624

High

604618

SOX2
Transcription factor SOX-2

1

20

High-throughput

0.618

High

604761

LEF1
Lymphoid enhancer-binding factor 1

1

20

Small-scale

0.618

High

140733

NOP56
Nucleolar protein 56

2

4

High-throughput

0.611

High

604703

CAMKV
CaM kinase-like vesicle-associated protein

3

1

High-throughput

0.604

High

604682

RSBN1
Lysine-specific demethylase 9

2

0

High-throughput

0.602

High

604756

CPNE7
Copine-7

2

0

High-throughput

0.602

High

190806

RPA34
DNA-directed RNA polymerase I subunit RPA34

2

9

Small-scale

0.595

High

604738

RPA49
DNA-directed RNA polymerase I subunit RPA49

2

1

Small-scale

0.595

High

604611

IRS1
Insulin receptor substrate 1

2

13

Small-scale

0.584

High

604628

H2B1C
Histone H2B type 1-C/E/F/G/I

2

17

High-throughput

0.584

High

604633

H31
Histone H3.1

2

20

High-throughput

0.584

High

604695

SMC5
Structural maintenance of chromosomes protein 5

2

11

High-throughput

0.584

High

604726

MBB1A
Myb-binding protein 1A

2

1

Small-scale

0.584

High

604638

SET
Protein SET

1

9

Small-scale

0.578

High

604671

TAF1C
TATA box-binding protein-associated factor RNA polymerase I subunit C

2

0

Small-scale

0.577

High

604637

MDM2
E3 ubiquitin-protein ligase Mdm2

2

1

Small-scale

0.571

High

604620

CEBPA
CCAAT/enhancer-binding protein alpha

2

20

Small-scale

0.563

High

604594

TAF1
Transcription initiation factor TFIID subunit 1

1

20

Small-scale

0.552

High

604632

CSK21
Casein kinase II subunit alpha

1

8

Small-scale

0.536

High

63951

CNOT1
CCR4-NOT transcription complex subunit 1

1

1

High-throughput

0.536

High

395446

ESR1
Estrogen receptor

1

20

High-throughput

0.536

High

474460

VIME
Vimentin

1

9

High-throughput

0.536

High

563141

CFTR
Cystic fibrosis transmembrane conductance regulator

1

3

High-throughput

0.536

High

604604

RL10
Large ribosomal subunit protein uL16

1

3

High-throughput

0.536

High

604614

LAP2B
Lamina-associated polypeptide 2, isoforms beta/gamma

1

2

High-throughput

0.536

High

604631

SUMO1
Small ubiquitin-related modifier 1

1

8

High-throughput

0.536

High

604634

SRPK2
SRSF protein kinase 2

1

12

High-throughput

0.536

High

604636

HNRPU
Heterogeneous nuclear ribonucleoprotein U

1

15

High-throughput

0.536

High

604642

TLE1
Transducin-like enhancer protein 1

1

20

Small-scale

0.536

High

604647

ZN543
Zinc finger protein 543

1

1

High-throughput

0.536

High

604660

ZN460
Zinc finger protein 460

1

3

High-throughput

0.536

High

604676

RN151
RING finger protein 151

1

13

High-throughput

0.536

High

604706

PI42C
Phosphatidylinositol 5-phosphate 4-kinase type-2 gamma

1

2

High-throughput

0.536

High

604725

MPP8
M-phase phosphoprotein 8

1

13

High-throughput

0.536

High

604749

LYAR
Cell growth-regulating nucleolar protein

1

1

High-throughput

0.536

High

604758

DAXX
Death domain-associated protein 6

1

1

High-throughput

0.536

High

604768

MB212
Protein mab-21-like 2

1

5

High-throughput

0.536

High

604727

SLF1
SMC5-SMC6 complex localization factor protein 1

1

15

High-throughput

0.515

High

604757

ZMYM2
Zinc finger MYM-type protein 2

1

3

Small-scale

0.515

High

604742

TAF1D
TATA box-binding protein-associated factor RNA polymerase I subunit D

1

0

Small-scale

0.513

High

604675

KNOP1
Lysine-rich nucleolar protein 1

1

0

High-throughput

0.513

High

604728

UTP23
rRNA-processing protein UTP23 homolog

1

0

High-throughput

0.513

High

604755

IKBL1
NF-kappa-B inhibitor-like protein 1

1

0

High-throughput

0.513

High

604621

GSK3A
Glycogen synthase kinase-3 alpha

1

5

High-throughput

0.508

High

169933

AURKA
Aurora kinase A

1

4

Small-scale

0.501

High

549045

CDK4
Cyclin-dependent kinase 4

1

11

Small-scale

0.501

High

604599

CCND1
G1/S-specific cyclin-D1

1

3

Small-scale

0.501

High

604600

CCNE1
G1/S-specific cyclin-E1

1

2

Small-scale

0.501

High

604601

CDK2
Cyclin-dependent kinase 2

1

8

Small-scale

0.501

High

604603

MK03
Mitogen-activated protein kinase 3

1

6

Small-scale

0.501

High

604607

MK01
Mitogen-activated protein kinase 1

1

6

Small-scale

0.501

High

604641

CENPC
Centromere protein C

1

6

Small-scale

0.501

High

604648

EP300
Histone acetyltransferase p300

1

20

Small-scale

0.501

High

604672

TAF1A
TATA box-binding protein-associated factor RNA polymerase I subunit A

1

1

Small-scale

0.501

High

604712

UBP7
Ubiquitin carboxyl-terminal hydrolase 7

1

10

High-throughput

0.501

High

604625

RAC3
Ras-related C3 botulinum toxin substrate 3

1

6

High-throughput

0.489

High

604692

PNM8A
Paraneoplastic antigen-like protein 8A

1

2

High-throughput

0.489

High

604697

PLCD3
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-3

1

3

High-throughput

0.489

High

604708

JPH3
Junctophilin-3

1

4

High-throughput

0.489

High

604739

TOLIP
Toll-interacting protein

1

1

High-throughput

0.489

High

604769

WIF1
Wnt inhibitory factor 1

1

3

High-throughput

0.489

High

604679

TAF1B
TATA box-binding protein-associated factor RNA polymerase I subunit B

1

0

Small-scale

0.480

High

128758

MEN1
Menin

1

3

High-throughput

0.479

High

131718

WWP2
NEDD4-like E3 ubiquitin-protein ligase WWP2

1

12

High-throughput

0.479

High

156930

CTRO
Citron Rho-interacting kinase

1

9

High-throughput

0.479

High

191527

MAGB2
Melanoma-associated antigen B2

1

5

Small-scale

0.479

High

224612

ACTN4
Alpha-actinin-4

1

7

Small-scale

0.479

High

243531

SMCA5
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 5

1

20

Small-scale

0.479

High

247656

NUPR1
Nuclear protein 1

1

1

High-throughput

0.479

High

254325

CC14B
Dual specificity protein phosphatase CDC14B

1

6

High-throughput

0.479

High

274460

DNJB6
DnaJ homolog subfamily B member 6

1

9

High-throughput

0.479

High

298297

DNJC8
DnaJ homolog subfamily C member 8

1

7

High-throughput

0.479

High

319373

UFL1
E3 UFM1-protein ligase 1

1

2

High-throughput

0.479

High

339648

KLF8
Krueppel-like factor 8

1

20

High-throughput

0.479

High

345339

STAU1
Double-stranded RNA-binding protein Staufen homolog 1

1

9

High-throughput

0.479

High

385434

LMNA
Prelamin-A/C [Cleaved into: Lamin-A/C

1

18

Small-scale

0.479

High

405769

MYCN
N-myc proto-oncogene protein

1

19

High-throughput

0.479

High

425297

ISG15
Ubiquitin-like protein ISG15

1

4

High-throughput

0.479

High

446621

NPM
Nucleophosmin

1

4

High-throughput

0.479

High

486931

PARP1
Poly [ADP-ribose] polymerase 1

1

17

High-throughput

0.479

High

519719

ANDR
Androgen receptor

1

20

High-throughput

0.479

High

587865

RFA2
Replication protein A 32 kDa subunit

1

8

High-throughput

0.479

High

604591

CEBPB
CCAAT/enhancer-binding protein beta

1

20

High-throughput

0.479

High

604592

TBP
TATA-box-binding protein

1

1

Small-scale

0.479

High

604593

BTF3
Transcription factor BTF3

1

2

High-throughput

0.479

High

604598

FBRL
rRNA 2'-O-methyltransferase fibrillarin

1

3

High-throughput

0.479

High

604602

BRD2
Bromodomain-containing protein 2

1

20

High-throughput

0.479

High

604605

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

8

High-throughput

0.479

High

604606

APEX1
DNA repair nuclease/redox regulator APEX1

1

3

High-throughput

0.479

High

604609

RFA3
Replication protein A 14 kDa subunit

1

6

High-throughput

0.479

High

604610

RL22
Large ribosomal subunit protein eL22

1

4

High-throughput

0.479

High

604612

BRCA1
Breast cancer type 1 susceptibility protein

1

8

Small-scale

0.479

High

604613

COIL
Coilin

1

2

High-throughput

0.479

High

604619

CENPA
Histone H3-like centromeric protein A

1

20

High-throughput

0.479

High

604623

FOXA1
Hepatocyte nuclear factor 3-alpha

1

20

High-throughput

0.479

High

604626

RS6
Small ribosomal subunit protein eS6

1

5

High-throughput

0.479

High

604627

H4
Histone H4

1

11

High-throughput

0.479

High

604629

RS24
Small ribosomal subunit protein eS24

1

2

High-throughput

0.479

High

604630

RL31
Large ribosomal subunit protein eL31

1

3

High-throughput

0.479

High

604635

H33
Histone H3.3

1

20

High-throughput

0.479

High

604639

EWS
RNA-binding protein EWS

1

12

High-throughput

0.479

High

604640

KIF23
Kinesin-like protein KIF23

1

6

High-throughput

0.479

High

604643

UBE3A
Ubiquitin-protein ligase E3A

1

12

High-throughput

0.479

High

604649

CHD3
Chromodomain-helicase-DNA-binding protein 3

1

20

High-throughput

0.479

High

604650

NFX1
Transcriptional repressor NF-X1

1

2

High-throughput

0.479

High

604651

CBX3
Chromobox protein homolog 3

1

16

High-throughput

0.479

High

604653

BIRC3
Baculoviral IAP repeat-containing protein 3

1

3

High-throughput

0.479

High

604654

HDAC1
Histone deacetylase 1

1

16

Small-scale

0.479

High

604657

TRI25
E3 ubiquitin/ISG15 ligase TRIM25

1

9

High-throughput

0.479

High

604658

GRM2
Metabotropic glutamate receptor 2

1

1

High-throughput

0.479

High

604661

GOGB1
Golgin subfamily B member 1

1

5

High-throughput

0.479

High

604664

SHPRH
E3 ubiquitin-protein ligase SHPRH

1

20

Small-scale

0.479

High

604665

SUZ12
Polycomb protein SUZ12

1

3

High-throughput

0.479

High

604666

TNIP1
TNFAIP3-interacting protein 1

1

11

High-throughput

0.479

High

604668

KIF14
Kinesin-like protein KIF14

1

10

High-throughput

0.479

High

604669

BRD3
Bromodomain-containing protein 3

1

20

High-throughput

0.479

High

604673

EZH2
Histone-lysine N-methyltransferase EZH2

1

14

High-throughput

0.479

High

604674

IF16
Gamma-interferon-inducible protein 16

1

3

High-throughput

0.479

High

604677

LARP7
La-related protein 7

1

16

High-throughput

0.479

High

604680

ZC3HD
Zinc finger CCCH domain-containing protein 13

1

16

High-throughput

0.479

High

604681

MYSM1
Deubiquitinase MYSM1

1

20

Small-scale

0.479

High

604684

IFIX
Pyrin and HIN domain-containing protein 1

1

3

High-throughput

0.479

High

604688

H32
Histone H3.2

1

20

Small-scale

0.479

High

604691

NAA40
N-alpha-acetyltransferase 40

1

3

High-throughput

0.479

High

604694

DHX40
Probable ATP-dependent RNA helicase DHX40

1

4

High-throughput

0.479

High

604696

SLX4
Structure-specific endonuclease subunit SLX4

1

10

High-throughput

0.479

High

604698

ZBTB2
Zinc finger and BTB domain-containing protein 2

1

9

High-throughput

0.479

High

604699

SIR6
NAD-dependent protein deacylase sirtuin-6

1

5

High-throughput

0.479

High

604700

CGAS
Cyclic GMP-AMP synthase

1

5

High-throughput

0.479

High

604705

NUP43
Nucleoporin Nup43

1

19

High-throughput

0.479

High

604707

DOT1L
Histone-lysine N-methyltransferase, H3 lysine-79 specific

1

2

High-throughput

0.479

High

604709

DNJC9
DnaJ homolog subfamily C member 9

1

9

High-throughput

0.479

High

604713

FBXW7
F-box/WD repeat-containing protein 7

1

11

High-throughput

0.479

High

604714

UTP4
U3 small nucleolar RNA-associated protein 4 homolog

1

16

High-throughput

0.479

High

604718

SNR40
U5 small nuclear ribonucleoprotein 40 kDa protein

1

16

High-throughput

0.479

High

604720

DDRGK
DDRGK domain-containing protein 1

1

3

High-throughput

0.479

High

604722

PSB7
Proteasome subunit beta type-7

1

2

High-throughput

0.479

High

604723

CDC5L
Cell division cycle 5-like protein

1

5

High-throughput

0.479

High

604724

RING2
E3 ubiquitin-protein ligase RING2

1

20

High-throughput

0.479

High

604729

DDX23
Probable ATP-dependent RNA helicase DDX23

1

11

High-throughput

0.479

High

604730

DDA1
DET1- and DDB1-associated protein 1

1

1

High-throughput

0.479

High

604731

KLF16
Krueppel-like factor 16

1

15

High-throughput

0.479

High

604734

MK67I
MKI67 FHA domain-interacting nucleolar phosphoprotein

1

8

High-throughput

0.479

High

604735

YTHD1
YTH domain-containing family protein 1

1

10

High-throughput

0.479

High

604737

UBE2O
(E3-independent) E2 ubiquitin-conjugating enzyme

1

2

High-throughput

0.479

High

604740

CHM4B
Charged multivesicular body protein 4b

1

7

High-throughput

0.479

High

604741

SENP3
Sentrin-specific protease 3

1

2

Small-scale

0.479

High

604743

MET14
N(6)-adenosine-methyltransferase non-catalytic subunit METTL14

1

1

High-throughput

0.479

High

604744

BRD7
Bromodomain-containing protein 7

1

20

High-throughput

0.479

High

604746

ANLN
Anillin

1

4

High-throughput

0.479

High

604748

DJC17
DnaJ homolog subfamily C member 17

1

10

High-throughput

0.479

High

604751

TE2IP
Telomeric repeat-binding factor 2-interacting protein 1

1

4

High-throughput

0.479

High

604754

NOP53
Ribosome biogenesis protein NOP53

1

2

Small-scale

0.479

High

604760

ZRAN1
Ubiquitin thioesterase ZRANB1

1

10

High-throughput

0.479

High

604764

FBW1A
F-box/WD repeat-containing protein 1A

1

13

High-throughput

0.479

High

604766

ZN330
Zinc finger protein 330

1

3

High-throughput

0.479

High

193980

R113A
E3 ubiquitin-protein ligase RNF113A

1

0

High-throughput

0.458

High

224883

BUD23
18S rRNA

1

0

Small-scale

0.458

High

604678

MIDN
Midnolin

1

0

High-throughput

0.458

High

604704

FBX22
F-box only protein 22

1

0

High-throughput

0.458

High

604716

DCPS
m7GpppX diphosphatase

1

0

High-throughput

0.458

High

604719

MCRS1
Microspherule protein 1

1

0

Small-scale

0.458

High

604721

ZN363
RING finger and CHY zinc finger domain-containing protein 1

1

0

High-throughput

0.458

High

604752

RRN3
RNA polymerase I-specific transcription initiation factor RRN3

1

0

Small-scale

0.458

High

604763

NSF1C
NSFL1 cofactor p47

1

0

High-throughput

0.458

High

604644

BTK
Tyrosine-protein kinase BTK

1

6

High-throughput

0.445

High

604689

HDGR2
Hepatoma-derived growth factor-related protein 2

1

16

High-throughput

0.445

High

604732

HEMGN
Hemogen

1

2

Small-scale

0.445

High

271879

OBSL1
Obscurin-like protein 1

1

2

High-throughput

0.437

High

411311

NTRK1
High affinity nerve growth factor receptor

1

7

High-throughput

0.437

High

519045

COX8A
Cytochrome c oxidase subunit 8A, mitochondrial

1

1

High-throughput

0.437

High

551603

NFH
Neurofilament heavy polypeptide

1

11

High-throughput

0.437

High

604596

ERBB3
Receptor tyrosine-protein kinase erbB-3

1

9

Small-scale

0.437

High

604608

GRK5
G protein-coupled receptor kinase 5

1

5

High-throughput

0.437

High

604615

PK3CA
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform

1

2

Small-scale

0.437

High

604656

FLOT2
Flotillin-2

1

2

High-throughput

0.437

High

604663

CUL7
Cullin-7

1

3

High-throughput

0.437

High

604683

A16L1
Autophagy-related protein 16-1

1

14

High-throughput

0.437

High

604686

TRI67
Tripartite motif-containing protein 67

1

18

High-throughput

0.437

High

604717

CHM4C
Charged multivesicular body protein 4c

1

7

High-throughput

0.437

High

604733

ACE2
Angiotensin-converting enzyme 2

1

1

High-throughput

0.437

High

604736

TRI31
E3 ubiquitin-protein ligase TRIM31

1

12

High-throughput

0.437

High

604750

B3GN2
N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase 2

1

1

High-throughput

0.437

High

604762

HECD1
E3 ubiquitin-protein ligase HECTD1

1

13

High-throughput

0.437

High

604767

IRS2
Insulin receptor substrate 2

1

12

Small-scale

0.437

High

48902

MED19
Mediator of RNA polymerase II transcription subunit 19

1

0

High-throughput

0.426

High

604670

TCAL1
Transcription elongation factor A protein-like 1

1

0

High-throughput

0.426

High

604702

IN80E
INO80 complex subunit E

1

0

High-throughput

0.426

High

421139

SCG1
Secretogranin-1

1

6

High-throughput

0.417

High

254786

HCN1
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1

1

1

High-throughput

0.407

High

604646

GOGA2
Golgin subfamily A member 2

1

13

High-throughput

0.407

High

604667

SYLM
Leucine--tRNA ligase, mitochondrial

1

2

High-throughput

0.407

High

604685

SCMC2
Mitochondrial adenyl nucleotide antiporter SLC25A25

1

5

High-throughput

0.407

High

604753

ERAP1
Endoplasmic reticulum aminopeptidase 1

1

1

High-throughput

0.407

High

604616

PE2R3
Prostaglandin E2 receptor EP3 subtype

3

0

High-throughput

0.347

High

604759

VTI1B
Vesicle transport through interaction with t-SNAREs homolog 1B

3

0

High-throughput

0.347

High

604595

MK
Midkine

2

0

High-throughput

0.328

High

604687

NKAP1
Uncharacterized protein NKAPD1

2

0

High-throughput

0.328

High

604693

SULF2
Extracellular sulfatase Sulf-2

2

0

High-throughput

0.313

High

515874

SAA1
Serum amyloid A-1 protein

1

0

High-throughput

0.279

Low

604652

NOGG
Noggin

1

0

High-throughput

0.279

Low

604659

FGFP1
Fibroblast growth factor-binding protein 1

1

0

High-throughput

0.279

Low

604690

GOGA7
Golgin subfamily A member 7

1

0

High-throughput

0.279

Low

604765

KLH20
Kelch-like protein 20

1

0

High-throughput

0.279

Low

604624

EVC
EvC complex member EVC

1

0

High-throughput

0.269

Low

336852

AHSA1
Activator of 90 kDa heat shock protein ATPase homolog 1

1

0

Small-scale

0.249

Low

604597

KCNA3
Potassium voltage-gated channel subfamily A member 3

1

0

Small-scale

0.249

Low

604645

PUR1
Amidophosphoribosyltransferase

1

0

High-throughput

0.249

Low

604701

SYT2
Synaptotagmin-2

1

0

High-throughput

0.232

Low

604715

CC049
Putative uncharacterized protein C3orf49

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025