HitPredict

Interactor 1: REST (Q13127)
RE1-silencing transcription factor (Neural-restrictive silencer factor) (X2 box repressor)
Gene: REST

Interactor 2: SIN3A (Q96ST3)
Paired amphipathic helix protein Sin3a (Histone deacetylase complex subunit Sin3a) (Transcriptional corepressor Sin3a)
Gene: SIN3A

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.56	0.60	0.584

The method score is based on:

Property	Details
Experiments	10491605, 21693630
Identification Methods	affinity chromatography technology
Interaction Type	physical association

The annotation score is based on:

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000122 - negative regulation of transcription by RNA polymerase II GO:0002244 - hematopoietic progenitor cell differentiation GO:0003682 - chromatin binding GO:0005634 - nucleus GO:0005654 - nucleoplasm and 5 others more... GO:0017053 - transcription repressor complex GO:0045666 - positive regulation of neuron differentiation GO:0045892 - negative regulation of DNA-templated transcription GO:0061629 - RNA polymerase II-specific DNA-binding transcription factor binding GO:1902459 - positive regulation of stem cell population maintenance
Homologous interactions	1

Homologous interactions

Color coding for hit scores

	1	1097
Hs

1	1273

Service provided by Combinatics, Japan

Last updated: 15 Jul 2024