Protein: PMS1
PMS1 protein homolog 1 (DNA mismatch repair protein PMS1)

Gene: PMS1
Organism: Homo sapiens
Interactions: 117
UniProt ID: P54277

Gene Ontology (top 5):
GO:0003677 - DNA binding
GO:0005524 - ATP binding
GO:0005634 - nucleus
GO:0006298 - mismatch repair
GO:0009410 - response to xenobiotic stimulus

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

827358

MLH1
DNA mismatch repair protein Mlh1

9

14

Small-scale

0.971

High

928674

FAN1
Fanconi-associated nuclease 1

5

6

Small-scale

0.714

High

846571

MSH2
DNA mismatch repair protein Msh2

1

20

Small-scale

0.618

High

910826

IMA1
Importin subunit alpha-1

1

3

High-throughput

0.618

High

913287

MSH6
DNA mismatch repair protein Msh6

1

20

Small-scale

0.618

High

928611

PMS1
PMS1 protein homolog 1

1

14

High-throughput

0.618

High

610274

PRS6A
26S proteasome regulatory subunit 6A

2

4

High-throughput

0.611

High

928659

FANCJ
Fanconi anemia group J protein

2

2

High-throughput

0.611

High

907965

DYLT3
Dynein light chain Tctex-type 3

2

1

High-throughput

0.606

High

928638

BBS7
BBSome complex member BBS7

2

0

High-throughput

0.602

High

928622

CUL3
Cullin-3

2

3

High-throughput

0.584

High

928667

MCM9
DNA helicase MCM9

2

5

Small-scale

0.584

High

186323

RA51B
DNA repair protein RAD51 homolog 2

1

3

High-throughput

0.536

High

605982

CAN2
Calpain-2 catalytic subunit

1

1

High-throughput

0.536

High

74458

HNRC2
Heterogeneous nuclear ribonucleoprotein C-like 2

1

0

High-throughput

0.513

High

158421

RFXK
DNA-binding protein RFXANK

1

0

High-throughput

0.513

High

353803

PTTG1
Securin

1

0

High-throughput

0.513

High

549554

PRPS2
Ribose-phosphate pyrophosphokinase 2

1

0

High-throughput

0.513

High

595717

H13
Histone H1.3

1

0

High-throughput

0.513

High

928618

AHNK
Neuroblast differentiation-associated protein AHNAK

1

0

High-throughput

0.513

High

928632

RAD9B
Cell cycle checkpoint control protein RAD9B

1

0

High-throughput

0.513

High

928653

TCPQM
T-complex protein 1 subunit theta-like 2

1

0

High-throughput

0.513

High

928656

NPAS1
Neuronal PAS domain-containing protein 1

1

0

High-throughput

0.513

High

928660

DUS16
Dual specificity protein phosphatase 16

1

0

High-throughput

0.513

High

928662

UBXN6
UBX domain-containing protein 6

1

0

High-throughput

0.513

High

391009

TRFL
Lactotransferrin

1

0

High-throughput

0.493

High

366402

FA12
Coagulation factor XII

1

3

High-throughput

0.489

High

374499

RASH
GTPase HRas

1

1

High-throughput

0.489

High

539528

PYGB
Glycogen phosphorylase, brain form

1

1

High-throughput

0.489

High

928627

VAMP3
Vesicle-associated membrane protein 3

1

2

High-throughput

0.489

High

928634

GLT10
Polypeptide N-acetylgalactosaminyltransferase 10

1

2

High-throughput

0.489

High

133987

IPO5
Importin-5

1

2

High-throughput

0.479

High

135906

P3C2A
Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha

1

3

High-throughput

0.479

High

180260

RPAC1
DNA-directed RNA polymerases I and III subunit RPAC1

1

1

High-throughput

0.479

High

253239

REV3L
DNA polymerase zeta catalytic subunit

1

2

High-throughput

0.479

High

325751

UBR5
E3 ubiquitin-protein ligase UBR5

1

1

High-throughput

0.479

High

411644

NTRK1
High affinity nerve growth factor receptor

1

1

High-throughput

0.479

High

413472

P53
Cellular tumor antigen p53

1

2

High-throughput

0.479

High

473878

NFIC
Nuclear factor 1 C-type

1

12

High-throughput

0.479

High

507722

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

1

3

High-throughput

0.479

High

588297

RFA2
Replication protein A 32 kDa subunit

1

1

High-throughput

0.479

High

695025

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

2

High-throughput

0.479

High

713974

PML
Protein PML

1

7

High-throughput

0.479

High

717737

2AAA
Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform

1

2

High-throughput

0.479

High

769685

RFC4
Replication factor C subunit 4

1

2

High-throughput

0.479

High

769828

RFC2
Replication factor C subunit 2

1

4

High-throughput

0.479

High

769955

RFC1
Replication factor C subunit 1

1

6

High-throughput

0.479

High

853448

UBP5
Ubiquitin carboxyl-terminal hydrolase 5

1

2

High-throughput

0.479

High

897673

CDK9
Cyclin-dependent kinase 9

1

1

High-throughput

0.479

High

904264

BRCA2
Breast cancer type 2 susceptibility protein

1

1

High-throughput

0.479

High

928613

PRS4
26S proteasome regulatory subunit 4

1

2

High-throughput

0.479

High

928616

H31
Histone H3.1

1

3

High-throughput

0.479

High

928617

H33
Histone H3.3

1

3

High-throughput

0.479

High

928619

NFIA
Nuclear factor 1 A-type

1

12

High-throughput

0.479

High

928620

ATR
Serine/threonine-protein kinase ATR

1

4

High-throughput

0.479

High

928621

CUL1
Cullin-1

1

3

High-throughput

0.479

High

928623

UBP2L
Ubiquitin-associated protein 2-like

1

1

High-throughput

0.479

High

928624

MCM6
DNA replication licensing factor MCM6

1

2

High-throughput

0.479

High

928625

NFIX
Nuclear factor 1 X-type

1

12

High-throughput

0.479

High

928626

NONO
Non-POU domain-containing octamer-binding protein

1

1

High-throughput

0.479

High

928633

PARPT
Protein mono-ADP-ribosyltransferase TIPARP

1

2

High-throughput

0.479

High

928635

ABCAD
ATP-binding cassette sub-family A member 13

1

1

High-throughput

0.479

High

928636

NAA40
N-alpha-acetyltransferase 40

1

1

High-throughput

0.479

High

928639

SMC5
Structural maintenance of chromosomes protein 5

1

1

High-throughput

0.479

High

928640

SLX4
Structure-specific endonuclease subunit SLX4

1

2

High-throughput

0.479

High

928644

UBP13
Ubiquitin carboxyl-terminal hydrolase 13

1

1

High-throughput

0.479

High

928646

SNR40
U5 small nuclear ribonucleoprotein 40 kDa protein

1

1

High-throughput

0.479

High

928652

RANB9
Ran-binding protein 9

1

1

High-throughput

0.479

High

928654

MMS19
MMS19 nucleotide excision repair protein homolog

1

3

High-throughput

0.479

High

928668

TE2IP
Telomeric repeat-binding factor 2-interacting protein 1

1

1

High-throughput

0.479

High

928670

XPO7
Exportin-7

1

6

High-throughput

0.479

High

928672

EXO1
Exonuclease 1

1

5

High-throughput

0.479

High

928673

SMC3
Structural maintenance of chromosomes protein 3

1

1

High-throughput

0.479

High

928675

TRRAP
Transformation/transcription domain-associated protein

1

4

High-throughput

0.479

High

138919

USP9Y
Ubiquitin carboxyl-terminal hydrolase 9Y

1

0

High-throughput

0.458

High

251549

CCNT1
Cyclin-T1

1

0

High-throughput

0.458

High

293420

CD123
Translation initiation factor eIF2 assembly protein

1

0

High-throughput

0.458

High

342805

HERC2
E3 ubiquitin-protein ligase HERC2

1

0

High-throughput

0.458

High

365340

PGK1
Phosphoglycerate kinase 1

1

0

High-throughput

0.458

High

541908

TOP1
DNA topoisomerase 1

1

0

High-throughput

0.458

High

767785

RFA3
Replication protein A 14 kDa subunit

1

0

High-throughput

0.458

High

854611

RAGP1
Ran GTPase-activating protein 1

1

0

High-throughput

0.458

High

928629

BRE1A
E3 ubiquitin-protein ligase BRE1A

1

0

High-throughput

0.458

High

928643

HELB
DNA helicase B

1

0

High-throughput

0.458

High

928649

HS12B
Heat shock 70 kDa protein 12B

1

0

High-throughput

0.458

High

928655

CDC5L
Cell division cycle 5-like protein

1

0

High-throughput

0.458

High

928657

AKAP9
A-kinase anchor protein 9

1

0

High-throughput

0.458

High

928664

MOV10
Helicase MOV-10

1

0

High-throughput

0.458

High

928647

AURKB
Aurora kinase B

1

3

High-throughput

0.445

High

331728

MTMR5
Myotubularin-related protein 5

1

2

High-throughput

0.437

High

928614

DYLT1
Dynein light chain Tctex-type 1

1

1

High-throughput

0.437

High

928630

RN123
E3 ubiquitin-protein ligase RNF123

1

1

High-throughput

0.437

High

928637

MTMRD
Myotubularin-related protein 13

1

2

High-throughput

0.437

High

928651

IPO9
Importin-9

1

2

High-throughput

0.437

High

928658

PSD2
PH and SEC7 domain-containing protein 2

1

3

High-throughput

0.437

High

928665

CYLD
Ubiquitin carboxyl-terminal hydrolase CYLD

1

1

High-throughput

0.437

High

248854

GSDME
Gasdermin-E

1

1

High-throughput

0.407

High

437651

HEPS
Serine protease hepsin

1

2

High-throughput

0.407

High

928628

FSCN1
Fascin

1

2

Small-scale

0.407

High

928631

A16L1
Autophagy-related protein 16-1

1

1

High-throughput

0.407

High

928642

FXL16
F-box/LRR-repeat protein 16

1

1

High-throughput

0.407

High

928650

FRMD6
FERM domain-containing protein 6

1

3

High-throughput

0.407

High

928661

S17A9
Voltage-gated purine nucleotide uniporter SLC17A9

1

1

High-throughput

0.407

High

928669

PP4RL
Putative serine/threonine-protein phosphatase 4 regulatory subunit 1-like

1

2

High-throughput

0.407

High

190338

COPT1
High affinity copper uptake protein 1

1

0

High-throughput

0.279

Low

239030

ZNRD2
Protein ZNRD2

1

0

High-throughput

0.279

Low

296767

ST1C4
Sulfotransferase 1C4

1

0

High-throughput

0.279

Low

928615

GBG5

1

0

High-throughput

0.279

Low

928641

KLH34
Kelch-like protein 34

1

0

High-throughput

0.279

Low

928645

SNX21
Sorting nexin-21

1

0

High-throughput

0.279

Low

928666

PHAG1
Phosphoprotein associated with glycosphingolipid-enriched microdomains 1

1

0

High-throughput

0.279

Low

928676

KCNE3
Potassium voltage-gated channel subfamily E member 3

1

0

High-throughput

0.279

Low

928612

CDC42
Cell division control protein 42 homolog

1

0

High-throughput

0.261

Low

928671

NUP50
Nuclear pore complex protein Nup50

1

0

High-throughput

0.249

Low

928648

C170L
Cep170-like protein

1

0

High-throughput

0.232

Low

928663

DJC25
DnaJ homolog subfamily C member 25

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025