HitPredict

Interactor 1: G3V7T8 (G3V7T8)
DLG associated protein 3
Gene: Dlgap3

Interactor 2: SHAN3 (Q9JLU4)
SH3 and multiple ankyrin repeat domains protein 3 (Shank3) (Proline-rich synapse-associated protein 2) (ProSAP2) (SPANK-2)
Gene: Shank3

Species: Rattus norvegicus

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.46	1.00	0.680

Property	Details
Experiments	10433269
Identification Methods	two hybrid, pull down
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	GKAP~PDZ_6
Common GO terms	GO:0050804 - modulation of chemical synaptic transmission GO:0098978 - glutamatergic synapse
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 977 Rn			1 1740
+	Mm
		1115961 DLGP3_MOUSE (1-977): 0: 1255: 99.59		SHAN3_MOUSE (1-1740): 1.11e-179: 590: 98.68
+	Hs
		327247 DLGP3_HUMAN (1-977): 0: 1243: 95.00		SHAN3_HUMAN (1-1740): 4.71e-171: 566: 93.52
+	Mm
		1116003 DLGP2_MOUSE (1-977): 0: 1089: 45.30		SHAN3_MOUSE (1-1740): 1.11e-179: 590: 98.68
+	Hs
		327248 DLGP3_HUMAN (1-977): 0: 1243: 95.00		SHAN2_HUMAN (8-1737): 4.41e-125: 436: 41.06
+	Rn
		956996 DLGP1_RAT (1-977): 0: 1055: 37.73		SHAN3_RAT (1-1740): 0: 608: 100.00
+	Hs
		145954 DLGP1_HUMAN (1-977): 0: 1088: 38.64		SHAN3_HUMAN (1-1740): 4.71e-171: 566: 93.52
+	Hs
		1316300 DLGP2_HUMAN (1-977): 0: 1081: 45.61		SHAN3_HUMAN (1-1740): 4.71e-171: 566: 93.52
+	Mm
		1116115 DLGP1_MOUSE (1-977): 0: 1055: 37.73		SHAN3_MOUSE (1-1740): 1.11e-179: 590: 98.68
+	Hs
		145956 DLGP1_HUMAN (1-977): 0: 1088: 38.64		SHAN2_HUMAN (8-1737): 4.41e-125: 436: 41.06
+	Hs
		1349917 DLGP2_HUMAN (1-977): 0: 1081: 45.61		SHAN2_HUMAN (8-1737): 4.41e-125: 436: 41.06
+	Mm
		69915 DLGP4_MOUSE (1-977): 0: 898: 35.71		SHAN3_MOUSE (1-1740): 1.11e-179: 590: 98.68
+	Hs
		1316315 DLGP4_HUMAN (1-977): 0: 887: 35.53		SHAN3_HUMAN (1-1740): 4.71e-171: 566: 93.52
+	Mm
		1194593 DLGP1_MOUSE (1-977): 0: 1055: 37.73		SHAN2_MOUSE (332-1737): 1.91e-94: 339: 34.81
+	Rn
		956997 DLGP1_RAT (1-977): 0: 1055: 37.73		SHAN2_RAT (332-1737): 1.31e-93: 337: 35.05
+	Mm
		1160650 DLGP1_MOUSE (1-977): 0: 1055: 37.73		CSKI1_MOUSE (104-1506): 1.24e-84: 308: 15.53
+	Hs
		1357785 DLGP4_HUMAN (1-977): 0: 887: 35.53		SHAN2_HUMAN (8-1737): 4.41e-125: 436: 41.06
+	Rn
		957003 DLGP2_RAT (1-977): 0: 1093: 45.58		SHAN1_RAT (350-1735): 3.93e-33: 143: 12.71
+	Hs
		145958 DLGP1_HUMAN (1-977): 0: 1088: 38.64		SHAN1_HUMAN (362-1735): 1.74e-28: 127: 13.65
+	Rn
		956998 DLGP1_RAT (1-977): 0: 1055: 37.73		SHAN1_RAT (350-1735): 3.93e-33: 143: 12.71
+	Mm
		88376 DLGP1_MOUSE (1-977): 0: 1055: 37.73		SHAN1_MOUSE (350-1735): 1.65e-32: 141: 12.79