HitPredict - High confidence protein-protein interactions

Interactor 1: TADBP (Q13148)
TAR DNA-binding protein 43 (TDP-43)
Gene: TARDBP

Interactor 2: TADBP (Q13148)
TAR DNA-binding protein 43 (TDP-43)
Gene: TARDBP

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.96	1.00	0.984

Property	Details
Experiments	19465477, 29715546, 35271311, 23575225, 22193716, 20020773, 26099433, 19383787, 21666678, 26735904, 29531287, 31235914, 23384725
Identification Methods	pull down, affinity chromatography technology, anti tag coimmunoprecipitation, transmission electron microscopy, molecular sieving, classical fluorescence spectroscopy, atomic force microscopy, nuclear magnetic resonance, 3D electron microscopy, x-ray crystallography and 3 others more... fluorescence technology, cross-linking study, comigration in sds page
Interaction Type	direct interaction, physical association, disulfide bond

Property	Details
Interacting Pfam domains	RRM_1~RRM_1, TDP43_N~TDP43_N
Common GO terms	GO:0000978 - RNA polymerase II cis-regulatory region sequence-specific DNA binding GO:0001933 - negative regulation of protein phosphorylation GO:0003677 - DNA binding GO:0003690 - double-stranded DNA binding GO:0003723 - RNA binding and 29 others more... GO:0003730 - mRNA 3'-UTR binding GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005726 - perichromatin fibrils GO:0005739 - mitochondrion GO:0006397 - mRNA processing GO:0008289 - lipid binding GO:0008380 - RNA splicing GO:0010468 - regulation of gene expression GO:0010494 - cytoplasmic stress granule GO:0010629 - negative regulation of gene expression GO:0016607 - nuclear speck GO:0031647 - regulation of protein stability GO:0032024 - positive regulation of insulin secretion GO:0034976 - response to endoplasmic reticulum stress GO:0035061 - interchromatin granule GO:0042307 - positive regulation of protein import into nucleus GO:0042752 - regulation of circadian rhythm GO:0042981 - regulation of apoptotic process GO:0043232 - intracellular non-membrane-bounded organelle GO:0043922 - negative regulation by host of viral transcription GO:0048511 - rhythmic process GO:0051726 - regulation of cell cycle GO:0061158 - 3'-UTR-mediated mRNA destabilization GO:0070935 - 3'-UTR-mediated mRNA stabilization GO:0071765 - nuclear inner membrane organization GO:0097157 - pre-mRNA intronic binding GO:0140693 - molecular condensate scaffold activity GO:1990000 - amyloid fibril formation
Homologous interactions	18

Homologous interactions

Color coding for hit scores

	1	414
Hs

1	414

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Last updated: 15 Jul 2024