Protein: PURB
Transcriptional regulator protein Pur-beta (Purine-rich element-binding protein B)

Gene: PURB
Organism: Homo sapiens
Interactions: 117
UniProt ID: Q96QR8

Gene Ontology (top 5):
GO:0000122 - negative regulation of transcription by RNA polymerase II
GO:0000900 - mRNA regulatory element binding translation repressor activity
GO:0000977 - RNA polymerase II transcription regulatory region sequence-specific DNA binding
GO:0000981 - DNA-binding transcription factor activity, RNA polymerase II-specific
GO:0001227 - DNA-binding transcription repressor activity, RNA polymerase II-specific

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1400981

PURG
Purine-rich element-binding protein gamma

2

5

High-throughput

0.789

High

476781

RSSA
Small ribosomal subunit protein uS2

3

2

High-throughput

0.667

High

1194301

LARP7
La-related protein 7

3

6

High-throughput

0.656

High

979154

RS6
Small ribosomal subunit protein eS6

3

2

High-throughput

0.650

High

586843

RS2
Small ribosomal subunit protein uS5

3

0

High-throughput

0.638

High

1400980

CNOT7
CCR4-NOT transcription complex subunit 7

3

0

High-throughput

0.638

High

396754

ESR1
Estrogen receptor

3

5

High-throughput

0.633

High

649397

H1T
Histone H1t

2

8

High-throughput

0.628

High

1140000

RRS1
Ribosome biogenesis regulatory protein homolog

2

2

High-throughput

0.628

High

1400974

H2AW
Core histone macro-H2A.2

2

5

High-throughput

0.628

High

419148

H2A1B
Histone H2A type 1-B/E

2

4

High-throughput

0.611

High

765815

BMI1
Polycomb complex protein BMI-1

2

2

High-throughput

0.611

High

1253118

ZN497
Zinc finger protein 497

2

6

High-throughput

0.606

High

1400971

LN28A
Protein lin-28 homolog A

2

11

High-throughput

0.601

High

1383212

SOSB2
SOSS complex subunit B2

2

0

High-throughput

0.580

High

1400977

MBD2
Methyl-CpG-binding domain protein 2

2

0

High-throughput

0.580

High

1126639

GRB7
Growth factor receptor-bound protein 7

2

3

High-throughput

0.571

High

1367069

ESR2
Estrogen receptor beta

2

5

High-throughput

0.571

High

436717

KPCB
Protein kinase C beta type

2

0

High-throughput

0.547

High

191763

MAGB2
Melanoma-associated antigen B2

1

1

High-throughput

0.536

High

287101

PRKRA
Interferon-inducible double-stranded RNA-dependent protein kinase activator A

1

8

High-throughput

0.536

High

301176

RL1D1
Ribosomal L1 domain-containing protein 1

1

1

High-throughput

0.536

High

428924

RLA0
Large ribosomal subunit protein uL10

1

2

High-throughput

0.536

High

521876

H14
Histone H1.4

1

8

High-throughput

0.536

High

564246

CFTR
Cystic fibrosis transmembrane conductance regulator

1

1

High-throughput

0.536

High

596309

H12
Histone H1.2

1

8

High-throughput

0.536

High

658351

RS3
Small ribosomal subunit protein uS3

1

2

High-throughput

0.536

High

686359

RL13
Large ribosomal subunit protein eL13

1

1

High-throughput

0.536

High

785380

RL4
Large ribosomal subunit protein uL4

1

1

High-throughput

0.536

High

809796

RS19
Small ribosomal subunit protein eS19

1

1

High-throughput

0.536

High

842493

RL35
Large ribosomal subunit protein uL29

1

1

High-throughput

0.536

High

849231

KSYK
Tyrosine-protein kinase SYK

1

2

High-throughput

0.536

High

854241

KI67
Proliferation marker protein Ki-67

1

1

High-throughput

0.536

High

860899

RS10
Small ribosomal subunit protein eS10

1

2

High-throughput

0.536

High

969377

RS8
Small ribosomal subunit protein eS8

1

2

High-throughput

0.536

High

975879

RL7A
Large ribosomal subunit protein eL8

1

1

High-throughput

0.536

High

978672

RL23A
Large ribosomal subunit protein uL23

1

1

High-throughput

0.536

High

984919

RL31
Large ribosomal subunit protein eL31

1

1

High-throughput

0.536

High

994737

YBOX1
Y-box-binding protein 1

1

10

High-throughput

0.536

High

1006640

SRPK2
SRSF protein kinase 2

1

10

High-throughput

0.536

High

1112133

KRR1
KRR1 small subunit processome component homolog

1

2

High-throughput

0.536

High

1114065

CUL3
Cullin-3

1

3

High-throughput

0.536

High

1151181

OASL
2'-5'-oligoadenylate synthase-like protein

1

3

High-throughput

0.536

High

1281449

ZN467
Zinc finger protein 467

1

8

High-throughput

0.536

High

1370525

FGF13
Fibroblast growth factor 13

1

1

High-throughput

0.536

High

1390582

NEIL1
Endonuclease 8-like 1

1

1

High-throughput

0.536

High

1400964

UTP23
rRNA-processing protein UTP23 homolog

1

1

High-throughput

0.536

High

1400982

ZN346
Zinc finger protein 346

1

2

High-throughput

0.536

High

1400983

ABT1
Activator of basal transcription 1

1

2

High-throughput

0.536

High

1400986

YBOX2
Y-box-binding protein 2

1

10

High-throughput

0.536

High

997956

CSK21
Casein kinase II subunit alpha

1

0

High-throughput

0.527

High

1400979

MD2L2
Mitotic spindle assembly checkpoint protein MAD2B

1

1

High-throughput

0.515

High

788751

SRP14
Signal recognition particle 14 kDa protein

1

0

High-throughput

0.513

High

1260404

H1FNT
Testis-specific H1 histone

1

0

High-throughput

0.513

High

1400966

CPEB1
Cytoplasmic polyadenylation element-binding protein 1

1

3

High-throughput

0.500

High

211397

RFOX2
RNA binding protein fox-1 homolog 2

1

4

High-throughput

0.481

High

129349

MEN1
Menin

1

1

High-throughput

0.479

High

350115

SNAI1
Zinc finger protein SNAI1

1

4

High-throughput

0.479

High

372899

MYC
Myc proto-oncogene protein

1

3

High-throughput

0.479

High

401335

RAF1
RAF proto-oncogene serine/threonine-protein kinase

1

1

High-throughput

0.479

High

406535

MYCN
N-myc proto-oncogene protein

1

3

High-throughput

0.479

High

472998

RU17
U1 small nuclear ribonucleoprotein 70 kDa

1

5

High-throughput

0.479

High

504956

H2AB2
Histone H2A-Bbd type 2/3

1

6

High-throughput

0.479

High

754947

H2B1B
Histone H2B type 1-B

1

1

High-throughput

0.479

High

775271

FUS
RNA-binding protein FUS

1

1

High-throughput

0.479

High

810303

RL3
Large ribosomal subunit protein uL3

1

1

High-throughput

0.479

High

951818

PTEN
Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN

1

1

Small-scale

0.479

High

960217

RL26
Large ribosomal subunit protein uL24

1

1

High-throughput

0.479

High

970943

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

1

High-throughput

0.479

High

980174

H4
Histone H4

1

1

High-throughput

0.479

High

1024781

VIGLN
Vigilin

1

4

High-throughput

0.479

High

1067618

EP300
Histone acetyltransferase p300

1

1

High-throughput

0.479

High

1087506

GRSF1
G-rich sequence factor 1

1

5

High-throughput

0.479

High

1096174

TADBP
TAR DNA-binding protein 43

1

4

High-throughput

0.479

High

1100971

G3BP1
Ras GTPase-activating protein-binding protein 1

1

2

High-throughput

0.479

High

1215778

RC3H1
Roquin-1

1

3

High-throughput

0.479

High

1252499

LN28B
Protein lin-28 homolog B

1

11

High-throughput

0.479

High

1271802

MEPCE
7SK snRNA methylphosphate capping enzyme

1

1

High-throughput

0.479

High

1288228

LYRIC
Protein LYRIC

1

1

Small-scale

0.479

High

1290664

ZCH18
Zinc finger CCCH domain-containing protein 18

1

3

High-throughput

0.479

High

1330910

CGAS
Cyclic GMP-AMP synthase

1

1

High-throughput

0.479

High

1400962

RING2
E3 ubiquitin-protein ligase RING2

1

2

High-throughput

0.479

High

1400963

RIOK1
Serine/threonine-protein kinase RIO1

1

1

High-throughput

0.479

High

1400967

DDX24
ATP-dependent RNA helicase DDX24

1

1

High-throughput

0.479

High

1400972

RC3H2
Roquin-2

1

3

High-throughput

0.479

High

1400975

UBP36
Ubiquitin carboxyl-terminal hydrolase 36

1

3

High-throughput

0.479

High

1400978

NXF1
Nuclear RNA export factor 1

1

0

High-throughput

0.460

High

325059

HEXI1
Protein HEXIM1

1

0

High-throughput

0.458

High

589462

RFA2
Replication protein A 32 kDa subunit

1

0

High-throughput

0.458

High

696266

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

0

High-throughput

0.458

High

768942

RFA3
Replication protein A 14 kDa subunit

1

0

High-throughput

0.458

High

1045664

TF65
Transcription factor p65

1

0

High-throughput

0.458

High

1400973

ANLN
Anillin

1

0

High-throughput

0.458

High

530244

TAU
Microtubule-associated protein tau

1

3

High-throughput

0.445

High

983405

RS30
Ubiquitin-like FUBI-ribosomal protein eS30 fusion protein

1

1

High-throughput

0.445

High

1400984

AKP8L
A-kinase anchor protein 8-like

1

1

High-throughput

0.445

High

106506

APRIO
Alternative prion protein

1

1

High-throughput

0.437

High

787067

FLT3
Receptor-type tyrosine-protein kinase FLT3

1

2

High-throughput

0.437

High

1255146

TRI67
Tripartite motif-containing protein 67

1

3

High-throughput

0.437

High

1286876

TM11B
Transmembrane protease serine 11B

1

2

High-throughput

0.437

High

1400969

Q9H4D1
Receptor-interacting serine/threonine-protein kinase 4

1

1

High-throughput

0.437

High

1400970

PKHA4
Pleckstrin homology domain-containing family A member 4

1

2

High-throughput

0.437

High

944037

RIPK4
Receptor-interacting serine/threonine-protein kinase 4

1

1

High-throughput

0.407

High

1352091

Q8TE30
RNA-directed DNA polymerase

1

1

Small-scale

0.407

High

1400968

MAGT1
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit MAGT1

1

1

High-throughput

0.407

High

887142

CEBPA
CCAAT/enhancer-binding protein alpha

1

0

High-throughput

0.391

High

1348448

LNX1
E3 ubiquitin-protein ligase LNX

2

0

High-throughput

0.316

High

1400965

AP1M1
AP-1 complex subunit mu-1

2

0

High-throughput

0.316

High

1400987

PCDBE
Protocadherin beta-14

2

0

High-throughput

0.316

High

438906

CD1A
T-cell surface glycoprotein CD1a

1

0

High-throughput

0.279

Low

657292

KALM
Anosmin-1

1

0

High-throughput

0.279

Low

733419

CCR1
C-C chemokine receptor type 1

1

0

High-throughput

0.279

Low

1339966

O52K2
Olfactory receptor 52K2

1

0

High-throughput

0.279

Low

418372

RPN2
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2

1

0

High-throughput

0.249

Low

1135054

CUL7
Cullin-7

1

0

High-throughput

0.249

Low

1400985

CLC4E
C-type lectin domain family 4 member E

1

0

High-throughput

0.249

Low

1400976

UVRAG
UV radiation resistance-associated gene protein

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025