HitPredict

Interactor 1: TADBP (Q13148)
TAR DNA-binding protein 43 (TDP-43)
Gene: TARDBP

Interactor 2: SRSF6 (Q13247)
Serine/arginine-rich splicing factor 6 (Pre-mRNA-splicing factor SRP55) (Splicing factor, arginine/serine-rich 6)
Gene: SRSF6

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	20020773
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	RRM_1~RRM_1
Common GO terms	GO:0003723 - RNA binding GO:0005654 - nucleoplasm GO:0016607 - nuclear speck
Homologous interactions	19

Homologous interactions

Color coding for hit scores

	1 414 Hs			1 344
+	Mm
		857368 TADBP_MOUSE (1-414): 1.47e-79: 253: 96.14		TIA1_MOUSE (2-335): 1.54e-33: 129: 15.46
+	Hs
		201707 MSI1H_HUMAN (96-409): 4.25e-61: 203: 23.93		RBM4B_HUMAN (1-343): 2.62e-45: 160: 18.23
+	Dm
		597049 RB27C_DROME (99-400): 4.23e-73: 236: 28.17		PABP_DROME (1-192): 1.5e-30: 123: 15.69
+	Hs
		474020 PAB4L_HUMAN (2-276): 8.18e-56: 189: 16.96		SRSF6_HUMAN (1-323): 3.2e-43: 154: 100.00
+	Hs
		1025728 TADBP_HUMAN (1-414): 4.24e-84: 264: 100.00		PABP4_HUMAN (101-191): 1.26e-12: 70.7: 21.88
+	Hs
		516491 TADBP_HUMAN (1-414): 4.24e-84: 264: 100.00		PABP1_HUMAN (101-191): 1.28e-11: 67.6: 19.79
+	Hs
		963510 TADBP_HUMAN (1-414): 4.24e-84: 264: 100.00		TIAR_HUMAN (102-272): 2.65e-09: 59.9: 13.19
+	Mm
		857324 TIA1_MOUSE (99-413): 1.08e-36: 139: 12.92		Q542V3_MOUSE (1-343): 1.15e-52: 182: 51.93
+	Mm
		857340 TIA1_MOUSE (99-413): 1.08e-36: 139: 12.92		SRSF1_MOUSE (3-188): 3.02e-54: 180: 36.65
+	Hs
		162035 HNRDL_HUMAN (62-376): 5.62e-71: 231: 23.60		PABP4_HUMAN (101-191): 1.26e-12: 70.7: 21.88
+	Hs
		161948 HNRDL_HUMAN (62-376): 5.62e-71: 231: 23.60		PABP1_HUMAN (101-191): 1.28e-11: 67.6: 19.79
+	Hs
		516424 ROA3_HUMAN (98-269): 2.33e-69: 225: 28.57		PABP1_HUMAN (101-191): 1.28e-11: 67.6: 19.79
+	Hs
		474021 PAB4L_HUMAN (2-276): 8.18e-56: 189: 16.96		PABP4_HUMAN (101-191): 1.26e-12: 70.7: 21.88
+	Hs
		474017 PAB4L_HUMAN (2-276): 8.18e-56: 189: 16.96		SRSF3_HUMAN (3-78): 2.4e-09: 57.4: 46.84
+	Hs
		516495 PABP4_HUMAN (98-274): 3.77e-37: 144: 19.02		PABP1_HUMAN (101-191): 1.28e-11: 67.6: 19.79
+	Hs
		680422 TIA1_HUMAN (99-413): 2.4e-38: 144: 13.76		TIA1_HUMAN (2-116): 2.8e-11: 66.1: 17.50
+	Mm
		665745 TIA1_MOUSE (99-413): 1.08e-36: 139: 12.92		PABP1_MOUSE (101-191): 1.39e-11: 67.6: 19.79
+	Hs
		680439 TIA1_HUMAN (99-413): 2.4e-38: 144: 13.76		TIAR_HUMAN (102-272): 2.65e-09: 59.9: 13.19
+	Hs
		680437 TIA1_HUMAN (99-413): 2.4e-38: 144: 13.76		SRSF3_HUMAN (3-78): 2.4e-09: 57.4: 46.84