Protein: PURA
Transcriptional activator protein Pur-alpha (Purine-rich single-stranded DNA-binding protein alpha)

Gene: PURA
Organism: Homo sapiens
Interactions: 185
UniProt ID: Q00577

Gene Ontology (top 5):
GO:0000122 - negative regulation of transcription by RNA polymerase II
GO:0000781 - chromosome, telomeric region
GO:0000900 - mRNA regulatory element binding translation repressor activity
GO:0000977 - RNA polymerase II transcription regulatory region sequence-specific DNA binding
GO:0000981 - DNA-binding transcription factor activity, RNA polymerase II-specific

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1025768

PURG
Purine-rich element-binding protein gamma

1

5

High-throughput

0.691

High

1025754

LN28A
Protein lin-28 homolog A

3

11

High-throughput

0.650

High

1025680

PURA
Transcriptional activator protein Pur-alpha

1

5

Small-scale

0.647

High

395919

ESR1
Estrogen receptor

3

5

High-throughput

0.633

High

521647

H14
Histone H1.4

2

8

High-throughput

0.628

High

624032

E2AK2
Interferon-induced, double-stranded RNA-activated protein kinase

2

2

High-throughput

0.628

High

1025699

RRS1
Ribosome biogenesis regulatory protein homolog

2

2

High-throughput

0.628

High

1025727

ZCRB1
Zinc finger CCHC-type and RNA-binding motif-containing protein 1

2

3

High-throughput

0.628

High

182279

WDR46
WD repeat-containing protein 46

2

3

High-throughput

0.611

High

765396

BMI1
Polycomb complex protein BMI-1

2

2

High-throughput

0.611

High

969184

RS8
Small ribosomal subunit protein eS8

2

2

High-throughput

0.611

High

1025707

LARP7
La-related protein 7

2

6

High-throughput

0.611

High

1025714

LN28B
Protein lin-28 homolog B

2

11

High-throughput

0.611

High

1025681

E2F1
Transcription factor E2F1

2

1

Small-scale

0.602

High

529638

TAU
Microtubule-associated protein tau

2

3

High-throughput

0.601

High

400660

RAF1
RAF proto-oncogene serine/threonine-protein kinase

2

1

Small-scale

0.586

High

1025716

MEPCE
7SK snRNA methylphosphate capping enzyme

2

1

High-throughput

0.584

High

1025753

WDR76
WD repeat-containing protein 76

2

2

High-throughput

0.584

High

442672

RB
Retinoblastoma-associated protein

1

0

Small-scale

0.554

High

191610

MAGB2
Melanoma-associated antigen B2

1

1

High-throughput

0.536

High

228702

U3IP2
U3 small nucleolar RNA-interacting protein 2

1

2

High-throughput

0.536

High

286949

PRKRA
Interferon-inducible double-stranded RNA-dependent protein kinase activator A

1

8

High-throughput

0.536

High

290530

SURF6
Surfeit locus protein 6

1

1

High-throughput

0.536

High

301013

RL1D1
Ribosomal L1 domain-containing protein 1

1

1

High-throughput

0.536

High

428714

RLA0
Large ribosomal subunit protein uL10

1

2

High-throughput

0.536

High

476649

RSSA
Small ribosomal subunit protein uS2

1

2

High-throughput

0.536

High

502323

H2A1
Histone H2A type 1

1

4

High-throughput

0.536

High

595397

H15
Histone H1.5

1

8

High-throughput

0.536

High

595743

H13
Histone H1.3

1

8

High-throughput

0.536

High

596046

H12
Histone H1.2

1

8

High-throughput

0.536

High

658114

RS3
Small ribosomal subunit protein uS3

1

2

High-throughput

0.536

High

686101

RL13
Large ribosomal subunit protein eL13

1

1

High-throughput

0.536

High

785105

RL4
Large ribosomal subunit protein uL4

1

1

High-throughput

0.536

High

809592

RS19
Small ribosomal subunit protein eS19

1

1

High-throughput

0.536

High

842332

RL35
Large ribosomal subunit protein uL29

1

1

High-throughput

0.536

High

849142

KSYK
Tyrosine-protein kinase SYK

1

2

High-throughput

0.536

High

853997

KI67
Proliferation marker protein Ki-67

1

1

High-throughput

0.536

High

860710

RS10
Small ribosomal subunit protein eS10

1

2

High-throughput

0.536

High

886452

CTCF
Transcriptional repressor CTCF

1

11

High-throughput

0.536

High

935395

FGF8
Fibroblast growth factor 8

1

1

High-throughput

0.536

High

978477

RL23A
Large ribosomal subunit protein uL23

1

1

High-throughput

0.536

High

978873

RS6
Small ribosomal subunit protein eS6

1

2

High-throughput

0.536

High

984717

RL31
Large ribosomal subunit protein eL31

1

1

High-throughput

0.536

High

1006339

SRPK2
SRSF protein kinase 2

1

10

High-throughput

0.536

High

1008684

RED1
Double-stranded RNA-specific editase 1

1

3

High-throughput

0.536

High

1016399

SRSF3
Serine/arginine-rich splicing factor 3

1

8

High-throughput

0.536

High

1025683

H11
Histone H1.1

1

8

High-throughput

0.536

High

1025684

FAK1
Focal adhesion kinase 1

1

2

High-throughput

0.536

High

1025685

SRSF4
Serine/arginine-rich splicing factor 4

1

5

High-throughput

0.536

High

1025688

SRSF5
Serine/arginine-rich splicing factor 5

1

7

High-throughput

0.536

High

1025689

SRSF6
Serine/arginine-rich splicing factor 6

1

8

High-throughput

0.536

High

1025692

KRR1
KRR1 small subunit processome component homolog

1

2

High-throughput

0.536

High

1025693

CUL1
Cullin-1

1

3

High-throughput

0.536

High

1025694

CUL3
Cullin-3

1

3

High-throughput

0.536

High

1025701

RBMS2
RNA-binding motif, single-stranded-interacting protein 2

1

3

High-throughput

0.536

High

1025703

OASL
2'-5'-oligoadenylate synthase-like protein

1

3

High-throughput

0.536

High

1025705

H2A2C
Histone H2A type 2-C

1

4

High-throughput

0.536

High

1025706

RN151
RING finger protein 151

1

2

High-throughput

0.536

High

1025718

LYRIC
Protein LYRIC

1

1

High-throughput

0.536

High

1025722

PACE1
Protein-associating with the carboxyl-terminal domain of ezrin

1

2

High-throughput

0.536

High

1025731

DYRK2
Dual specificity tyrosine-phosphorylation-regulated kinase 2

1

5

High-throughput

0.536

High

1025737

NEIL1
Endonuclease 8-like 1

1

1

High-throughput

0.536

High

1025740

ZN668
Zinc finger protein 668

1

8

High-throughput

0.536

High

1025748

REXO4
RNA exonuclease 4

1

1

High-throughput

0.536

High

1025757

ZNF71
Endothelial zinc finger protein induced by tumor necrosis factor alpha

1

6

High-throughput

0.536

High

1025758

DDX21
Nucleolar RNA helicase 2

1

2

High-throughput

0.536

High

1025763

F120A
Constitutive coactivator of PPAR-gamma-like protein 1

1

2

High-throughput

0.536

High

1025770

ZN346
Zinc finger protein 346

1

2

High-throughput

0.536

High

1025772

ABT1
Activator of basal transcription 1

1

2

High-throughput

0.536

High

1025774

SRPK3
SRSF protein kinase 3

1

8

High-throughput

0.536

High

1025775

MAST1
Microtubule-associated serine/threonine-protein kinase 1

1

1

High-throughput

0.536

High

1025776

YBOX2
Y-box-binding protein 2

1

10

High-throughput

0.536

High

1025777

RBM19
Probable RNA-binding protein 19

1

4

High-throughput

0.536

High

105764

APRIO
Alternative prion protein

2

1

High-throughput

0.533

High

976986

CNBP
CCHC-type zinc finger nucleic acid binding protein

1

1

High-throughput

0.515

High

1025767

MD2L2
Mitotic spindle assembly checkpoint protein MAD2B

1

1

High-throughput

0.515

High

548987

KPSH1
Serine/threonine-protein kinase H1

1

0

High-throughput

0.513

High

615744

RL17
Large ribosomal subunit protein uL22

1

0

High-throughput

0.513

High

824105

RL13A
Large ribosomal subunit protein uL13

1

0

High-throughput

0.513

High

898608

RL14
Large ribosomal subunit protein eL14

1

0

High-throughput

0.513

High

960688

RL15
Large ribosomal subunit protein eL15

1

0

High-throughput

0.513

High

1009188

PRR3
Proline-rich protein 3

1

0

High-throughput

0.513

High

1015966

RL19
Large ribosomal subunit protein eL19

1

0

High-throughput

0.513

High

1025720

CAND1
Cullin-associated NEDD8-dissociated protein 1

1

0

High-throughput

0.513

High

1025730

DGCR8
Microprocessor complex subunit DGCR8

1

0

High-throughput

0.513

High

1025742

MBB1A
Myb-binding protein 1A

1

0

High-throughput

0.513

High

1025744

LLPH
Protein LLP homolog

1

0

High-throughput

0.513

High

1025751

PLK3
Serine/threonine-protein kinase PLK3

1

0

High-throughput

0.513

High

1025761

LYAR
Cell growth-regulating nucleolar protein

1

0

High-throughput

0.513

High

185617

OGT1
UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit

1

1

High-throughput

0.501

High

251569

CCNT1
Cyclin-T1

1

3

Small-scale

0.501

High

951616

PTEN
Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN

1

1

High-throughput

0.501

High

1025745

CPEB1
Cytoplasmic polyadenylation element-binding protein 1

1

3

High-throughput

0.500

High

1025700

P2RY6
P2Y purinoceptor 6

1

1

High-throughput

0.489

High

1025713

SCYL2
SCY1-like protein 2

1

2

High-throughput

0.489

High

128974

MEN1
Menin

1

1

High-throughput

0.479

High

171865

ZN263
Zinc finger protein 263

1

12

Small-scale

0.479

High

241412

PRKN
E3 ubiquitin-protein ligase parkin

1

1

High-throughput

0.479

High

335094

ARI2
E3 ubiquitin-protein ligase ARIH2

1

1

High-throughput

0.479

High

349949

SNAI1
Zinc finger protein SNAI1

1

4

High-throughput

0.479

High

371776

MYC
Myc proto-oncogene protein

1

3

High-throughput

0.479

High

374528

RASH
GTPase HRas

1

2

Small-scale

0.479

High

375414

RASK
GTPase KRas

1

2

High-throughput

0.479

High

406074

MYCN
N-myc proto-oncogene protein

1

3

High-throughput

0.479

High

418942

H2A1B
Histone H2A type 1-B/E

1

4

High-throughput

0.479

High

464909

SP1
Transcription factor Sp1

1

9

Small-scale

0.479

High

472652

RU17
U1 small nuclear ribonucleoprotein 70 kDa

1

5

High-throughput

0.479

High

485073

ROA1
Heterogeneous nuclear ribonucleoprotein A1

1

1

High-throughput

0.479

High

504882

H2AB2
Histone H2A-Bbd type 2/3

1

6

High-throughput

0.479

High

507844

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

1

4

High-throughput

0.479

High

609987

VGFR1
Vascular endothelial growth factor receptor 1

1

2

High-throughput

0.479

High

612976

EGR1
Early growth response protein 1

1

13

Small-scale

0.479

High

731205

STIP1
Stress-induced-phosphoprotein 1

1

1

High-throughput

0.479

High

754801

H2B1B
Histone H2B type 1-B

1

1

High-throughput

0.479

High

777670

VGFR3
Vascular endothelial growth factor receptor 3

1

2

High-throughput

0.479

High

810048

RL3
Large ribosomal subunit protein uL3

1

1

High-throughput

0.479

High

970344

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

1

High-throughput

0.479

High

979505

H4
Histone H4

1

1

High-throughput

0.479

High

1024506

VIGLN
Vigilin

1

4

High-throughput

0.479

High

1025682

KIF23
Kinesin-like protein KIF23

1

2

High-throughput

0.479

High

1025686

EP300
Histone acetyltransferase p300

1

1

High-throughput

0.479

High

1025687

TADBP
TAR DNA-binding protein 43

1

4

High-throughput

0.479

High

1025690

G3BP1
Ras GTPase-activating protein-binding protein 1

1

2

High-throughput

0.479

High

1025695

CUL4A
Cullin-4A

1

3

High-throughput

0.479

High

1025697

RBM39
RNA-binding protein 39

1

3

High-throughput

0.479

High

1025708

HABP4
Intracellular hyaluronan-binding protein 4

1

1

High-throughput

0.479

High

1025709

RC3H1
Roquin-1

1

3

High-throughput

0.479

High

1025710

A16L1
Autophagy-related protein 16-1

1

2

High-throughput

0.479

High

1025715

TRI67
Tripartite motif-containing protein 67

1

3

High-throughput

0.479

High

1025719

ZCH18
Zinc finger CCCH domain-containing protein 18

1

3

High-throughput

0.479

High

1025721

ZC3H3
Zinc finger CCCH domain-containing protein 3

1

2

High-throughput

0.479

High

1025724

CGAS
Cyclic GMP-AMP synthase

1

1

High-throughput

0.479

High

1025725

SERB1
SERPINE1 mRNA-binding protein 1

1

1

High-throughput

0.479

High

1025733

FBXW7
F-box/WD repeat-containing protein 7

1

1

High-throughput

0.479

High

1025735

FUBP1
Far upstream element-binding protein 1

1

2

High-throughput

0.479

High

1025746

TRI31
E3 ubiquitin-protein ligase TRIM31

1

2

High-throughput

0.479

High

1025752

PKHA4
Pleckstrin homology domain-containing family A member 4

1

2

High-throughput

0.479

High

1025755

RC3H2
Roquin-2

1

3

High-throughput

0.479

High

1025756

BRD7
Bromodomain-containing protein 7

1

2

High-throughput

0.479

High

1025760

NHP2
H/ACA ribonucleoprotein complex subunit 2

1

1

High-throughput

0.479

High

1025764

UBP36
Ubiquitin carboxyl-terminal hydrolase 36

1

3

High-throughput

0.479

High

1025766

MKRN1
E3 ubiquitin-protein ligase makorin-1

1

2

Small-scale

0.479

High

1025769

AGO2
Protein argonaute-2

1

2

Small-scale

0.479

High

1025773

FZR1
Fizzy-related protein homolog

1

4

High-throughput

0.479

High

1025778

MAFB
Transcription factor MafB

1

1

High-throughput

0.479

High

293571

CD123
Translation initiation factor eIF2 assembly protein

1

0

High-throughput

0.458

High

411746

NTRK1
High affinity nerve growth factor receptor

1

0

High-throughput

0.458

High

634732

ITAX
Integrin alpha-X

1

0

Small-scale

0.458

High

834174

CSK
Tyrosine-protein kinase CSK

1

0

High-throughput

0.458

High

976208

RB11A
Ras-related protein Rab-11A

1

0

High-throughput

0.458

High

1025691

SNW1
SNW domain-containing protein 1

1

0

High-throughput

0.458

High

1025696

TRI14
Tripartite motif-containing protein 14

1

0

High-throughput

0.458

High

1025704

IF16
Gamma-interferon-inducible protein 16

1

0

High-throughput

0.458

High

1025729

DOT1L
Histone-lysine N-methyltransferase, H3 lysine-79 specific

1

0

High-throughput

0.458

High

1025734

IGSF8
Immunoglobulin superfamily member 8

1

0

High-throughput

0.458

High

1025738

PRR11
Proline-rich protein 11

1

0

High-throughput

0.458

High

1025739

DDRGK
DDRGK domain-containing protein 1

1

0

High-throughput

0.458

High

1025741

ANM1
Protein arginine N-methyltransferase 1

1

0

High-throughput

0.458

High

1025765

ZRAN1
Ubiquitin thioesterase ZRANB1

1

0

High-throughput

0.458

High

47514

RPSA2
Small ribosomal subunit protein uS2B

1

2

High-throughput

0.445

High

563629

CFTR
Cystic fibrosis transmembrane conductance regulator

1

1

High-throughput

0.445

High

952102

GBRL2
Gamma-aminobutyric acid receptor-associated protein-like 2

1

1

High-throughput

0.445

High

967667

PP1A
Serine/threonine-protein phosphatase PP1-alpha catalytic subunit

1

1

High-throughput

0.445

High

1025732

ESR2
Estrogen receptor beta

1

5

High-throughput

0.445

High

1025750

MLP3A
Microtubule-associated protein 1 light chain 3 alpha

1

1

High-throughput

0.445

High

1025717

TM11B
Transmembrane protease serine 11B

1

2

High-throughput

0.437

High

1025743

RIOK1
Serine/threonine-protein kinase RIO1

1

1

High-throughput

0.437

High

1025759

TMPS4
Transmembrane protease serine 4

1

2

High-throughput

0.437

High

1025771

HECD1
E3 ubiquitin-protein ligase HECTD1

1

2

High-throughput

0.437

High

254970

HCN1
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1

1

0

High-throughput

0.426

High

429739

JUN
Transcription factor Jun

1

0

High-throughput

0.426

High

1025747

ZDHC5
Palmitoyltransferase ZDHHC5

1

0

High-throughput

0.426

High

72766

B0UZZ8
WD repeat-containing protein 46

1

3

High-throughput

0.407

High

1025712

PKHA7
Pleckstrin homology domain-containing family A member 7

1

2

High-throughput

0.407

High

1025728

Q8TE30
RNA-directed DNA polymerase

1

1

Small-scale

0.407

High

1025749

MAGT1
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit MAGT1

1

1

High-throughput

0.407

High

1025702

SURF2
Surfeit locus protein 2

2

0

High-throughput

0.318

High

1025698

FGFP1
Fibroblast growth factor-binding protein 1

1

0

High-throughput

0.279

Low

1025736

SGK3
Serine/threonine-protein kinase Sgk3

1

0

High-throughput

0.279

Low

1025723

OTU6B
Deubiquitinase OTUD6B

1

0

Small-scale

0.269

Low

427874

ICAM1
Intercellular adhesion molecule 1

1

0

High-throughput

0.249

Low

1025711

RNF43
E3 ubiquitin-protein ligase RNF43

1

0

High-throughput

0.249

Low

1025762

B3GN2
N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase 2

1

0

High-throughput

0.249

Low

1025726

MOT11
Monocarboxylate transporter 11

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025