HitPredict

Interactor 1: TADBP (Q13148)
TAR DNA-binding protein 43 (TDP-43)
Gene: TARDBP

Interactor 2: PABP4 (Q13310)
Polyadenylate-binding protein 4 (PABP-4) (Poly(A)-binding protein 4) (Activated-platelet protein 1) (APP-1) (Inducible poly(A)-binding protein) (iPABP)
Gene: PABPC4

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	20020773
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	RRM_1~RRM_1
Common GO terms	GO:0003723 - RNA binding GO:0003730 - mRNA 3'-UTR binding GO:0005634 - nucleus GO:0010494 - cytoplasmic stress granule
Homologous interactions	18

Homologous interactions

Color coding for hit scores

	1 414 Hs			1 644
+	Hs
		162035 HNRDL_HUMAN (62-376): 5.62e-71: 231: 23.60		PABP4_HUMAN (1-644): 0: 585: 100.00
+	Hs
		516491 TADBP_HUMAN (1-414): 4.24e-84: 264: 100.00		PABP1_HUMAN (1-644): 0: 542: 74.54
+	Hs
		474021 PAB4L_HUMAN (2-276): 8.18e-56: 189: 16.96		PABP4_HUMAN (1-644): 0: 585: 100.00
+	Hs
		161948 HNRDL_HUMAN (62-376): 5.62e-71: 231: 23.60		PABP1_HUMAN (1-644): 0: 542: 74.54
+	Hs
		516424 ROA3_HUMAN (98-269): 2.33e-69: 225: 28.57		PABP1_HUMAN (1-644): 0: 542: 74.54
+	Hs
		516495 PABP4_HUMAN (98-274): 3.77e-37: 144: 19.02		PABP1_HUMAN (1-644): 0: 542: 74.54
+	Mm
		665745 TIA1_MOUSE (99-413): 1.08e-36: 139: 12.92		PABP1_MOUSE (1-644): 0: 542: 74.69
+	Hs
		516339 PABP1_HUMAN (2-382): 7.78e-31: 126: 15.95		PABP1_HUMAN (1-644): 0: 542: 74.54
+	Hs
		516689 PABP3_HUMAN (2-382): 7.84e-31: 126: 16.41		PABP1_HUMAN (1-644): 0: 542: 74.54
+	Dm
		597049 RB27C_DROME (99-400): 4.23e-73: 236: 28.17		PABP_DROME (2-464): 6.23e-64: 224: 22.09
+	Sc
		376562 PABP_YEAST (86-269): 2.74e-34: 136: 21.88		PABP_YEAST (2-290): 4.28e-66: 228: 30.07
+	Hs
		582263 TADBP_HUMAN (1-414): 4.24e-84: 264: 100.00		NUCL_HUMAN (2-89): 1.4e-20: 98.4: 31.82
+	Mm
		857368 TADBP_MOUSE (1-414): 1.47e-79: 253: 96.14		TIA1_MOUSE (4-86): 1.26e-12: 72: 30.12
+	Hs
		852134 ROA3_HUMAN (98-269): 2.33e-69: 225: 28.57		PABP5_HUMAN (4-93): 1.22e-15: 81: 23.33
+	Hs
		474034 PAB4L_HUMAN (2-276): 8.18e-56: 189: 16.96		PABP5_HUMAN (4-93): 1.22e-15: 81: 23.33
+	Hs
		1119141 PAP1L_HUMAN (96-274): 7.74e-38: 146: 17.74		PABP5_HUMAN (4-93): 1.22e-15: 81: 23.33
+	Hs
		516355 PABP1_HUMAN (2-382): 7.78e-31: 126: 15.95		NUCL_HUMAN (2-89): 1.4e-20: 98.4: 31.82
+	Hs
		680422 TIA1_HUMAN (99-413): 2.4e-38: 144: 13.76		TIA1_HUMAN (4-109): 7.62e-12: 69.5: 24.53