HitPredict

Interactor 1: CBX3 (Q13185)
Chromobox protein homolog 3 (HECH) (Heterochromatin protein 1 homolog gamma) (HP1 gamma) (Modifier 2 protein)
Gene: CBX3

Interactor 2: CHD1L (Q86WJ1)
Chromodomain-helicase-DNA-binding protein 1-like (EC 3.6.4.-) (Amplified in liver cancer protein 1)
Gene: CHD1L

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	19661379
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	Chromo~SNF2-rel_dom
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0006338 - chromatin remodeling GO:0006974 - DNA damage response GO:0090734 - site of DNA damage
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 183 Hs			1 897
+	Hs
		800446 CBX5_HUMAN (11-182): 1.62e-55: 175: 59.89		CHD1L_HUMAN (1-897): 0: 850: 100.00
+	Hs
		1027300 CBX3_HUMAN (1-183): 1.62e-71: 215: 100.00		CHD7_HUMAN (2-856): 0: 677: 29.16
+	Hs
		1027277 CBX3_HUMAN (1-183): 1.62e-71: 215: 100.00		CHD8_HUMAN (1-856): 0: 643: 27.69
+	Hs
		1027026 CBX3_HUMAN (1-183): 1.62e-71: 215: 100.00		CHD9_HUMAN (1-856): 0: 636: 28.03
+	Hs
		1027145 CBX3_HUMAN (1-183): 1.62e-71: 215: 100.00		CHD5_HUMAN (18-851): 0: 608: 30.09
+	Hs
		229384 CBX3_HUMAN (1-183): 1.62e-71: 215: 100.00		SMCA5_HUMAN (9-786): 0: 603: 32.60
+	Hs
		658667 CBX3_HUMAN (1-183): 1.62e-71: 215: 100.00		SMCA1_HUMAN (35-786): 0: 594: 32.63
+	Hs
		1018451 CBX3_HUMAN (1-183): 1.62e-71: 215: 100.00		CHD3_HUMAN (21-792): 0: 590: 31.44
+	Hs
		1027001 CBX3_HUMAN (1-183): 1.62e-71: 215: 100.00		CHD4_HUMAN (18-775): 0: 584: 32.19
+	Mm
		1161080 Q9DCC5_MOUSE (1-183): 1.62e-71: 215: 100.00		CHD4_MOUSE (18-775): 0: 584: 32.19
+	Hs
		846954 CBX3_HUMAN (1-183): 1.62e-71: 215: 100.00		SMCA4_HUMAN (3-782): 0: 567: 29.03
+	Hs
		800360 CBX5_HUMAN (11-182): 1.62e-55: 175: 59.89		CHD3_HUMAN (21-792): 0: 590: 31.44
+	Hs
		658650 CBX1_HUMAN (36-180): 1.02e-53: 170: 71.33		SMCA1_HUMAN (35-786): 0: 594: 32.63
+	Hs
		949764 CBX1_HUMAN (36-180): 1.02e-53: 170: 71.33		CHD3_HUMAN (21-792): 0: 590: 31.44
+	Hs
		800380 CBX5_HUMAN (11-182): 1.62e-55: 175: 59.89		CHD4_HUMAN (18-775): 0: 584: 32.19
+	Hs
		800320 CBX5_HUMAN (11-182): 1.62e-55: 175: 59.89		SMCA4_HUMAN (3-782): 0: 567: 29.03
+	Hs
		846923 CBX1_HUMAN (36-180): 1.02e-53: 170: 71.33		SMCA4_HUMAN (3-782): 0: 567: 29.03
+	Hs
		800319 CBX5_HUMAN (11-182): 1.62e-55: 175: 59.89		SMCA2_HUMAN (3-782): 8.8e-177: 555: 28.77
+	Hs
		846745 CBX1_HUMAN (36-180): 1.02e-53: 170: 71.33		SMCA2_HUMAN (3-782): 8.8e-177: 555: 28.77
+	Hs
		151406 CBX3_HUMAN (1-183): 1.62e-71: 215: 100.00		CHD1_HUMAN (40-526): 5.8e-112: 379: 45.51