HitPredict

Interactor 1: CBX3 (Q13185)
Chromobox protein homolog 3 (HECH) (Heterochromatin protein 1 homolog gamma) (HP1 gamma) (Modifier 2 protein)
Gene: CBX3

Interactor 2: NSD3 (Q9BZ95)
Histone-lysine N-methyltransferase NSD3 (EC 2.1.1.370) (EC 2.1.1.371) (Nuclear SET domain-containing protein 3) (Protein whistle) (WHSC1-like 1 isoform 9 with methyltransferase activity to lysine) (Wolf-Hirschhorn syndrome candidate 1-like protein 1) (WHSC1-like protein 1)
Gene: NSD3

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.62	0.60	0.614

Property	Details
Experiments	34079125, 20936779
Identification Methods	proximity labelling technology, two hybrid, two hybrid pooling approach
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000785 - chromatin GO:0005634 - nucleus GO:0005654 - nucleoplasm
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 183 Hs			1 1437
+	Hs
		1317731 V9HWG0_HUMAN (11-182): 1.62e-55: 175: 59.89		NSD3_HUMAN (1-1437): 0: 1169: 100.00
+	Hs
		331801 CBX3_HUMAN (1-183): 1.62e-71: 215: 100.00		NSD2_HUMAN (140-1414): 0: 825: 45.08
+	Hs
		1027262 CBX3_HUMAN (1-183): 1.62e-71: 215: 100.00		SUV92_HUMAN (903-1285): 1.04e-77: 265: 23.22
+	Hs
		203674 CBX3_HUMAN (1-183): 1.62e-71: 215: 100.00		SUV91_HUMAN (904-1285): 4e-73: 252: 22.56
+	Mm
		222468 Q9DCC5_MOUSE (1-183): 1.62e-71: 215: 100.00		SUV91_MOUSE (904-1285): 3.8e-72: 249: 22.56
+	Mm
		222460 CBX3_MOUSE (1-183): 4.67e-71: 214: 99.45		SUV91_MOUSE (904-1285): 3.8e-72: 249: 22.56
+	Mm
		613035 CBX3_MOUSE (1-183): 4.67e-71: 214: 99.45		SUV92_MOUSE (903-1285): 5.19e-68: 239: 22.99
+	Hs
		1027194 CBX3_HUMAN (1-183): 1.62e-71: 215: 100.00		EHMT2_HUMAN (1029-1281): 2.28e-60: 229: 22.84
+	Hs
		1027242 CBX3_HUMAN (1-183): 1.62e-71: 215: 100.00		SETD2_HUMAN (1004-1320): 1.62e-59: 228: 32.18
+	Hs
		1027268 CBX3_HUMAN (1-183): 1.62e-71: 215: 100.00		EHMT1_HUMAN (995-1301): 1.89e-59: 227: 20.54
+	Mm
		1125433 Q9DCC5_MOUSE (1-183): 1.62e-71: 215: 100.00		EHMT1_MOUSE (995-1301): 7.13e-59: 225: 20.83
+	Hs
		1331984 V9HWG0_HUMAN (11-182): 1.62e-55: 175: 59.89		SUV92_HUMAN (903-1285): 1.04e-77: 265: 23.22
+	Mm
		936655 Q9DCC5_MOUSE (1-183): 1.62e-71: 215: 100.00		EZH1_MOUSE (1076-1270): 3.93e-59: 220: 30.24
+	Mm
		1142295 Q9DCC5_MOUSE (1-183): 1.62e-71: 215: 100.00		EZH2_MOUSE (1076-1270): 1.26e-58: 218: 28.78
+	Hs
		203823 V9HWG0_HUMAN (11-182): 1.62e-55: 175: 59.89		SUV91_HUMAN (904-1285): 4e-73: 252: 22.56
+	Mm
		222467 CBX5_MOUSE (11-182): 1.21e-55: 175: 59.89		SUV91_MOUSE (904-1285): 3.8e-72: 249: 22.56
+	Mm
		1142272 CBX5_MOUSE (11-182): 1.21e-55: 175: 59.89		EZH2_MOUSE (1076-1270): 1.26e-58: 218: 28.78
+	Hs
		975237 CBX3_HUMAN (1-183): 1.62e-71: 215: 100.00		KMT2A_HUMAN (1131-1285): 7.1e-40: 164: 30.13
+	Hs
		1027195 CBX3_HUMAN (1-183): 1.62e-71: 215: 100.00		NSD1_HUMAN (91-724): 2.53e-28: 126: 15.30
+	Hs
		1027329 CBX3_HUMAN (1-183): 1.62e-71: 215: 100.00		KMT2B_HUMAN (1323-1421): 9.58e-09: 62.5: 19.83