Protein: REEP4
Receptor expression-enhancing protein 4

Gene: REEP4
Organism: Homo sapiens
Interactions: 207
UniProt ID: Q9H6H4

Gene Ontology (top 5):
GO:0005783 - endoplasmic reticulum
GO:0005789 - endoplasmic reticulum membrane
GO:0005881 - cytoplasmic microtubule
GO:0006998 - nuclear envelope organization
GO:0007084 - mitotic nuclear membrane reassembly

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

730244

1433B
14-3-3 protein beta/alpha

6

20

High-throughput

0.667

High

1049786

1433F
14-3-3 protein eta

5

20

High-throughput

0.654

High

1414452

DERL1
Derlin-1

3

3

High-throughput

0.653

High

1431746

3BHS7
3 beta-hydroxysteroid dehydrogenase type 7

3

2

High-throughput

0.653

High

1291498

RETR3
Reticulophagy regulator 3

3

7

Small-scale

0.650

High

1434638

SG196
Protein O-mannose kinase

3

0

High-throughput

0.638

High

691434

1433T
14-3-3 protein theta

4

20

High-throughput

0.630

High

966875

1433G
14-3-3 protein gamma

4

20

High-throughput

0.630

High

990738

1433Z
14-3-3 protein zeta/delta

4

20

High-throughput

0.630

High

941372

CAV3
Caveolin-3

2

5

High-throughput

0.628

High

1411239

REEP2
Receptor expression-enhancing protein 2

2

11

High-throughput

0.628

High

1434944

REEP1
Receptor expression-enhancing protein 1

2

11

High-throughput

0.628

High

972001

1433E
14-3-3 protein epsilon

2

6

High-throughput

0.611

High

1027182

REEP5
Receptor expression-enhancing protein 5

2

14

High-throughput

0.611

High

1031545

IFM3
Interferon-induced transmembrane protein 3

3

2

High-throughput

0.607

High

155503

C2C2L
Phospholipid transfer protein C2CD2L

2

1

High-throughput

0.606

High

180050

BET1
BET1 homolog

2

3

High-throughput

0.606

High

209110

CYB5B
Cytochrome b5 type B

2

1

High-throughput

0.606

High

280339

SC22B
Vesicle-trafficking protein SEC22b

2

2

High-throughput

0.606

High

325599

YIF1A
Protein YIF1A

2

3

High-throughput

0.606

High

333206

VAPB
Vesicle-associated membrane protein-associated protein B/C

2

5

High-throughput

0.606

High

346721

TM50A
Transmembrane protein 50A

2

1

High-throughput

0.606

High

360120

NB5R3
NADH-cytochrome b5 reductase 3

2

2

High-throughput

0.606

High

1005414

CP4F2
Cytochrome P450 4F2

2

2

High-throughput

0.606

High

1050060

PLP2
Proteolipid protein 2

2

5

High-throughput

0.606

High

1097889

STX5
Syntaxin-5

2

3

High-throughput

0.606

High

1327053

VMA12
Vacuolar ATPase assembly protein VMA12

2

1

High-throughput

0.606

High

1412860

YIPF4
Protein YIPF4

2

3

High-throughput

0.606

High

1413807

TM208
Transmembrane protein 208

2

3

High-throughput

0.606

High

1434950

PLCD
1-acyl-sn-glycerol-3-phosphate acyltransferase delta

2

2

High-throughput

0.606

High

1434956

ORML1
ORM1-like protein 1

2

1

High-throughput

0.606

High

1434964

TMX2
Thioredoxin-related transmembrane protein 2

2

1

High-throughput

0.606

High

1434965

UB2J1
Ubiquitin-conjugating enzyme E2 J1

2

3

High-throughput

0.606

High

835391

VIPR2
Vasoactive intestinal polypeptide receptor 2

3

4

High-throughput

0.604

High

1290971

TAXB1
Tax1-binding protein 1

3

1

High-throughput

0.604

High

595109

KCNA2
Potassium voltage-gated channel subfamily A member 2

2

3

High-throughput

0.601

High

944371

NAC3
Sodium/calcium exchanger 3

2

0

High-throughput

0.585

High

222205

NCK2
Cytoplasmic protein NCK2

2

0

High-throughput

0.580

High

1032136

FMO1
Flavin-containing monooxygenase 1

2

0

High-throughput

0.580

High

1060228

B2CL1
Bcl-2-like protein 1

2

0

High-throughput

0.580

High

1127862

ERG1
Squalene monooxygenase

2

0

High-throughput

0.580

High

1253310

DG2L6
Diacylglycerol O-acyltransferase 2-like protein 6

2

0

High-throughput

0.580

High

1324430

TM86A
Lysoplasmalogenase TMEM86A

2

0

High-throughput

0.580

High

1358714

SRALN
Sarcoplasmic/endoplasmic reticulum calcium ATPase regulator ARLN

2

0

High-throughput

0.580

High

1359667

GIMA1
GTPase IMAP family member 1

2

0

High-throughput

0.580

High

1434957

VTI1B
Vesicle transport through interaction with t-SNAREs homolog 1B

2

0

High-throughput

0.580

High

1434962

ERG28
Ergosterol biosynthetic protein 28 homolog

2

0

High-throughput

0.580

High

1434970

PEX16
Peroxisomal membrane protein PEX16

2

0

High-throughput

0.580

High

1434971

UBIA1
UbiA prenyltransferase domain-containing protein 1

2

0

High-throughput

0.580

High

1434972

SELK
Selenoprotein K

2

0

High-throughput

0.580

High

1434973

SERP1
Stress-associated endoplasmic reticulum protein 1

2

0

High-throughput

0.580

High

58679

FRMD3
FERM domain-containing protein 3

2

1

High-throughput

0.574

High

1336034

CTL5
Choline transporter-like protein 5

2

1

High-throughput

0.574

High

1409919

KCNS3
Delayed-rectifier potassium channel regulatory subunit KCNS3

2

1

High-throughput

0.574

High

1366236

LPAR1
Lysophosphatidic acid receptor 1

2

6

High-throughput

0.558

High

49698

T120B
Transmembrane protein 120B

2

2

High-throughput

0.553

High

252632

TSN2
Tetraspanin-2

2

9

High-throughput

0.553

High

257675

PRAF2
PRA1 family protein 2

2

8

High-throughput

0.553

High

278562

VAMP4
Vesicle-associated membrane protein 4

2

1

High-throughput

0.553

High

329663

LERL1
Leptin receptor overlapping transcript-like 1

2

1

High-throughput

0.553

High

339233

SFT2B
Vesicle transport protein SFT2B

2

2

High-throughput

0.553

High

539496

ITAM
Integrin alpha-M

2

1

High-throughput

0.553

High

549463

CD20
B-lymphocyte antigen CD20

2

1

High-throughput

0.553

High

662363

VAMP1
Vesicle-associated membrane protein 1

2

3

High-throughput

0.553

High

1100720

STX3
Syntaxin-3

2

1

High-throughput

0.553

High

1102455

BIK
Bcl-2-interacting killer

2

1

High-throughput

0.553

High

1200111

UNC50
Protein unc-50 homolog

2

1

High-throughput

0.553

High

1203347

TM128
Transmembrane protein 128

2

4

High-throughput

0.553

High

1208741

RTP2
Receptor-transporting protein 2

2

2

High-throughput

0.553

High

1310951

ZNT8
Proton-coupled zinc antiporter SLC30A8

2

2

High-throughput

0.553

High

1357636

SFT2A
Vesicle transport protein SFT2A

2

2

High-throughput

0.553

High

1380445

MAL2
Protein MAL2

2

2

High-throughput

0.553

High

1382943

S2546
Mitochondrial outer membrane protein SLC25A46

2

1

High-throughput

0.553

High

1386928

F241B
Protein FAM241B

2

2

High-throughput

0.553

High

1388071

RTP4
Receptor-transporting protein 4

2

2

High-throughput

0.553

High

1398562

CKLF3
CKLF-like MARVEL transmembrane domain-containing protein 3

2

5

High-throughput

0.553

High

1398920

SFXN2
Sideroflexin-2

2

2

High-throughput

0.553

High

1399565

DCBD2
Discoidin, CUB and LCCL domain-containing protein 2

2

1

High-throughput

0.553

High

1414536

HTAI2
Protein HTATIP2

2

1

High-throughput

0.553

High

1416212

FUND2
FUN14 domain-containing protein 2

2

2

High-throughput

0.553

High

1416292

SFXN3
Sideroflexin-3

2

2

High-throughput

0.553

High

1432036

TMM60
Transmembrane protein 60

2

1

High-throughput

0.553

High

1434949

KISHB
Protein kish-B

2

2

High-throughput

0.553

High

1434960

LAT2
Large neutral amino acids transporter small subunit 2

2

2

High-throughput

0.553

High

1434963

MAN1
Inner nuclear membrane protein Man1

2

2

High-throughput

0.553

High

158323

COPE
Coatomer subunit epsilon

1

2

High-throughput

0.536

High

329010

RTN3
Reticulon-3

1

6

High-throughput

0.536

High

773641

COPB2
Coatomer subunit beta'

1

3

High-throughput

0.536

High

932597

PTN5
Tyrosine-protein phosphatase non-receptor type 5

1

2

High-throughput

0.536

High

1041293

CAV1
Caveolin-1

1

5

High-throughput

0.536

High

1139272

AR6P1
ADP-ribosylation factor-like protein 6-interacting protein 1

1

3

High-throughput

0.536

High

1203795

TTMP
TPA-induced transmembrane protein

1

1

High-throughput

0.536

High

1231468

ATLA3
Atlastin-3

1

4

High-throughput

0.536

High

1238316

REEP3
Receptor expression-enhancing protein 3

1

11

High-throughput

0.536

High

1434946

RTN4
Reticulon-4

1

6

High-throughput

0.536

High

1434966

GOT1B
Vesicle transport protein GOT1B

1

1

High-throughput

0.536

High

730889

1433S
14-3-3 protein sigma

2

20

High-throughput

0.533

High

396947

ESR1
Estrogen receptor

2

1

High-throughput

0.521

High

1416858

TACAN
Transmembrane protein 120A

1

2

High-throughput

0.515

High

141869

ACKR2
Atypical chemokine receptor 2

1

2

High-throughput

0.489

High

349570

TSN15
Tetraspanin-15

1

6

High-throughput

0.489

High

477470

CD63
CD63 antigen

1

6

High-throughput

0.489

High

618422

TSN8
Tetraspanin-8

1

9

High-throughput

0.489

High

640469

C5AR1
C5a anaphylatoxin chemotactic receptor 1

1

7

High-throughput

0.489

High

669070

FPR2
N-formyl peptide receptor 2

1

6

High-throughput

0.489

High

669211

EDNRA
Endothelin-1 receptor

1

3

High-throughput

0.489

High

683338

TNR5
Tumor necrosis factor receptor superfamily member 5

1

1

High-throughput

0.489

High

688713

NKG2D
NKG2-D type II integral membrane protein

1

4

High-throughput

0.489

High

709280

AA2BR
Adenosine receptor A2b

1

2

High-throughput

0.489

High

905772

CAV2
Caveolin-2

1

5

High-throughput

0.489

High

1126252

PDE3A
cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A

1

1

High-throughput

0.489

High

1157140

KCA10
Potassium voltage-gated channel subfamily A member 10

1

3

High-throughput

0.489

High

1207771

TMM31
Transmembrane protein 31

1

1

High-throughput

0.489

High

1388190

CKLF5
CKLF-like MARVEL transmembrane domain-containing protein 5

1

4

High-throughput

0.489

High

528715

PPGB
Lysosomal protective protein

1

2

High-throughput

0.481

High

1388802

YIPF6
Protein YIPF6

1

3

High-throughput

0.481

High

48796

ESYT2
Extended synaptotagmin-2

1

4

High-throughput

0.479

High

363861

EGFR
Epidermal growth factor receptor

1

1

High-throughput

0.479

High

417759

RPN1
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1

1

1

High-throughput

0.479

High

895059

EMD
Emerin

1

2

High-throughput

0.479

High

951431

SC61B
Protein transport protein Sec61 subunit beta

1

1

High-throughput

0.479

High

962486

RHOA
Transforming protein RhoA

1

2

High-throughput

0.479

High

1111704

STIM1
Stromal interaction molecule 1

1

2

High-throughput

0.479

High

1309889

TEX2
Testis-expressed protein 2

1

1

High-throughput

0.479

High

1334000

DHB11
Estradiol 17-beta-dehydrogenase 11

1

5

High-throughput

0.479

High

1383078

LRC59
Leucine-rich repeat-containing protein 59

1

2

High-throughput

0.479

High

1395946

DNJC1
DnaJ homolog subfamily C member 1

1

2

High-throughput

0.479

High

1404210

SEC62
Translocation protein SEC62

1

2

High-throughput

0.479

High

1412665

ESYT1
Extended synaptotagmin-1

1

4

High-throughput

0.479

High

1431247

DJC25
DnaJ homolog subfamily C member 25

1

2

High-throughput

0.479

High

1434941

RETR1
Reticulophagy regulator 1

1

7

Small-scale

0.479

High

1434959

SEC63
Translocation protein SEC63 homolog

1

2

High-throughput

0.479

High

48205

A0AVG3
t-SNARE domain containing 1

1

3

High-throughput

0.470

High

328743

VAMP5
Vesicle-associated membrane protein 5

1

2

High-throughput

0.470

High

1202533

Q59EV6
Carboxypeptidase

1

2

High-throughput

0.470

High

1254316

TMPPE
Transmembrane protein with metallophosphoesterase domain

1

2

High-throughput

0.470

High

1434945

SFXN1
Sideroflexin-1

1

2

High-throughput

0.470

High

1434943

TMT1A
Thiol S-methyltransferase TMT1A

1

0

High-throughput

0.458

High

1434967

FBX7
F-box only protein 7

1

1

High-throughput

0.457

High

1258582

CR3L2
Cyclic AMP-responsive element-binding protein 3-like protein 2

1

1

High-throughput

0.445

High

1229455

TMM42
Transmembrane protein 42

1

2

High-throughput

0.439

High

1398901

TSNA1
t-SNARE domain-containing protein 1

1

5

High-throughput

0.439

High

1434951

TM14B
Transmembrane protein 14B

1

1

High-throughput

0.439

High

126803

RHOD
Rho-related GTP-binding protein RhoD

1

2

High-throughput

0.437

High

589688

RFA2
Replication protein A 32 kDa subunit

1

1

High-throughput

0.437

High

696507

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

1

High-throughput

0.437

High

769179

RFA3
Replication protein A 14 kDa subunit

1

1

High-throughput

0.437

High

820749

CEAM6
Cell adhesion molecule CEACAM6

1

1

High-throughput

0.437

High

901574

RAB7A
Ras-related protein Rab-7a

1

2

High-throughput

0.437

High

980326

H4
Histone H4

1

1

High-throughput

0.437

High

1005097

RNF4
E3 ubiquitin-protein ligase RNF4

1

2

High-throughput

0.437

High

1227462

A16L1
Autophagy-related protein 16-1

1

2

High-throughput

0.437

High

1238822

TECT3
Tectonic-3

1

3

High-throughput

0.437

High

1434948

ST7
Suppressor of tumorigenicity 7 protein

1

1

High-throughput

0.437

High

1434952

OTULL
Inactive ubiquitin thioesterase OTULINL

1

2

High-throughput

0.437

High

1434958

ZRAN1
Ubiquitin thioesterase ZRANB1

1

3

High-throughput

0.437

High

1434968

CBY1
Protein chibby homolog 1

1

1

High-throughput

0.437

High

1391509

BSCL2
Seipin

1

0

High-throughput

0.426

High

190258

MOT4
Monocarboxylate transporter 4

1

3

High-throughput

0.407

High

722619

CTR1
High affinity cationic amino acid transporter 1

1

2

High-throughput

0.407

High

957014

CXCR4
C-X-C chemokine receptor type 4

1

5

High-throughput

0.407

High

1312986

S35F2
Solute carrier family 35 member F2

1

4

High-throughput

0.407

High

1359500

CTL1
Choline transporter-like protein 1

1

1

High-throughput

0.407

High

1393206

TM169
Transmembrane protein 169

1

1

High-throughput

0.407

High

1428157

YIPF3
Protein YIPF3

2

0

High-throughput

0.328

High

251118

B4GT3
Beta-1,4-galactosyltransferase 3

2

0

High-throughput

0.318

High

74194

SMIM1
Small integral membrane protein 1

2

0

High-throughput

0.316

High

281483

MSPD3
Motile sperm domain-containing protein 3

2

0

High-throughput

0.316

High

297318

SERF1
Small EDRK-rich factor 1

2

0

High-throughput

0.316

High

335578

BMP10
Bone morphogenetic protein 10

2

0

High-throughput

0.316

High

391754

STAT
Statherin

2

0

High-throughput

0.316

High

438103

GLPB
Glycophorin-B

2

0

High-throughput

0.316

High

486874

C1S
Complement C1s subcomponent

2

0

High-throughput

0.316

High

642293

COMT
Catechol O-methyltransferase

2

0

High-throughput

0.316

High

944420

SYJ2B
Synaptojanin-2-binding protein

2

0

High-throughput

0.316

High

1030385

PMP22
Peripheral myelin protein 22

2

0

High-throughput

0.316

High

1081331

SMAGP
Small cell adhesion glycoprotein

2

0

High-throughput

0.316

High

1229388

LEMD1
LEM domain-containing protein 1

2

0

High-throughput

0.316

High

1244667

TMM65
Transmembrane protein 65

2

0

High-throughput

0.316

High

1256659

TPRG1
Tumor protein p63-regulated gene 1 protein

2

0

High-throughput

0.316

High

1331504

NRAC
Nutritionally-regulated adipose and cardiac enriched protein homolog

2

0

High-throughput

0.316

High

1333270

T229B
Transmembrane protein 229B

2

0

High-throughput

0.316

High

1340539

CLDN2
Claudin domain-containing protein 2

2

0

High-throughput

0.316

High

1340712

CC4L
C-C motif chemokine 4-like

2

0

High-throughput

0.316

High

1349018

TM254
Transmembrane protein 254

2

0

High-throughput

0.316

High

1359858

SELM
Selenoprotein M

2

0

High-throughput

0.316

High

1384068

TMM18
Transmembrane protein 18

2

0

High-throughput

0.316

High

1393237

TMM19
Transmembrane protein 19

2

0

High-throughput

0.316

High

1397165

DJC30
DnaJ homolog subfamily C member 30, mitochondrial

2

0

High-throughput

0.316

High

1413371

TM121
Transmembrane protein 121

2

0

High-throughput

0.316

High

1434953

TMM51
Transmembrane protein 51

2

0

High-throughput

0.316

High

1434954

TV23B
Golgi apparatus membrane protein TVP23 homolog B

2

0

High-throughput

0.316

High

1434961

LCAP
Leucyl-cystinyl aminopeptidase

2

0

High-throughput

0.316

High

1434969

TIM22
Mitochondrial import inner membrane translocase subunit Tim22

2

0

High-throughput

0.316

High

1155773

EZH2
Histone-lysine N-methyltransferase EZH2

1

0

High-throughput

0.279

Low

1251688

T184A
Transmembrane protein 184A

1

0

High-throughput

0.279

Low

1339982

OR6T1
Olfactory receptor 6T1

1

0

High-throughput

0.279

Low

1434942

PHAX
Phosphorylated adapter RNA export protein

1

0

High-throughput

0.279

Low

692263

VATL
V-type proton ATPase 16 kDa proteolipid subunit c

1

0

High-throughput

0.268

Low

1055143

CCG1
Voltage-dependent calcium channel gamma-1 subunit

1

0

High-throughput

0.268

Low

1434955

NINJ2
Ninjurin-2

1

0

High-throughput

0.251

Low

1400866

RAB3I
Rab-3A-interacting protein

1

0

High-throughput

0.249

Low

1434947

PXMP2
Peroxisomal membrane protein 2

1

0

High-throughput

0.249

Low

621523

HXK1
Hexokinase-1

1

0

High-throughput

0.232

Low

870416

S6A11
Sodium- and chloride-dependent GABA transporter 3

1

0

High-throughput

0.232

Low

1236317

MFSD5
Molybdate-anion transporter

1

0

High-throughput

0.232

Low

1288921

RIMS1
Regulating synaptic membrane exocytosis protein 1

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025