HitPredict

Interactor 1: CBLB (Q13191)
E3 ubiquitin-protein ligase CBL-B (EC 2.3.2.27) (Casitas B-lineage lymphoma proto-oncogene b) (RING finger protein 56) (RING-type E3 ubiquitin transferase CBL-B) (SH3-binding protein CBL-B) (Signal transduction protein CBL-B)
Gene: CBLB

Interactor 2: ITSN2 (Q9NZM3)
Intersectin-2 (SH3 domain-containing protein 1B) (SH3P18) (SH3P18-like WASP-associated protein)
Gene: ITSN2

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.44	0.60	0.515

Property	Details
Experiments	33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005509 - calcium ion binding GO:0005829 - cytosol GO:0005886 - plasma membrane
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 982 Hs			1 1697
+	Mm
		1112081 CBLB_MOUSE (1-982): 0: 873: 95.12		ITSN2_MOUSE (1-1697): 0: 904: 88.92
+	Hs
		1027606 CBLB_HUMAN (1-982): 0: 877: 100.00		ITSN1_HUMAN (2-1693): 0: 863: 56.23
+	Hs
		610517 CBL_HUMAN (25-976): 0: 675: 47.10		ITSN2_HUMAN (1-1697): 0: 969: 100.00
+	Mm
		610657 CBL_MOUSE (25-976): 0: 674: 47.47		ITSN2_MOUSE (1-1697): 0: 904: 88.92
+	Hs
		610415 CBL_HUMAN (25-976): 0: 675: 47.10		ITSN1_HUMAN (2-1693): 0: 863: 56.23
+	Mm
		610656 CBL_MOUSE (25-976): 0: 674: 47.47		ITSN1_MOUSE (2-1693): 0: 861: 56.37
+	Hs
		1027629 CBLB_HUMAN (1-982): 0: 877: 100.00		VAV3_HUMAN (1119-1589): 1.73e-66: 245: 15.37
+	Mm
		1112055 CBLB_MOUSE (1-982): 0: 873: 95.12		EP15R_MOUSE (13-132): 1.69e-16: 87.7: 27.87
+	Hs
		548699 CBLB_HUMAN (1-982): 0: 877: 100.00		VAV_HUMAN (526-1189): 1.23e-13: 78.3: 13.15
+	Hs
		1027604 CBLB_HUMAN (1-982): 0: 877: 100.00		ARHG7_HUMAN (770-1003): 4.21e-12: 73.3: 18.14
+	Hs
		855791 CBLB_HUMAN (1-982): 0: 877: 100.00		VAV2_HUMAN (614-1182): 8.45e-12: 72.6: 12.07
+	Mm
		82736 B9EKI5_MOUSE (1-982): 0: 852: 90.53		VAV2_MOUSE (614-1182): 1.63e-11: 71.4: 13.29
+	Dm
		112567 O46034_DROME (27-434): 0: 718: 71.39		M9ND00_DROME (1-447): 2.52e-32: 139: 14.35
+	Hs
		610520 CBL_HUMAN (25-976): 0: 675: 47.10		EP15R_HUMAN (3-509): 1.83e-36: 152: 16.67
+	Hs
		610518 CBL_HUMAN (25-976): 0: 675: 47.10		ARHGC_HUMAN (1189-1535): 2.93e-21: 103: 27.07
+	Mm
		610601 CBL_MOUSE (25-976): 0: 674: 47.47		EP15R_MOUSE (13-132): 1.69e-16: 87.7: 27.87
+	Hs
		548639 CBL_HUMAN (25-976): 0: 675: 47.10		VAV_HUMAN (526-1189): 1.23e-13: 78.3: 13.15
+	Hs
		610397 CBL_HUMAN (25-976): 0: 675: 47.10		ARHG7_HUMAN (770-1003): 4.21e-12: 73.3: 18.14
+	Hs
		610308 CBL_HUMAN (25-976): 0: 675: 47.10		VAV2_HUMAN (614-1182): 8.45e-12: 72.6: 12.07
+	Hs
		610407 CBL_HUMAN (25-976): 0: 675: 47.10		ARHG6_HUMAN (878-973): 2.21e-11: 71: 23.71