Protein: DGCR8
Microprocessor complex subunit DGCR8 (DiGeorge syndrome critical region 8)

Gene: DGCR8
Organism: Homo sapiens
Interactions: 239
UniProt ID: Q8WYQ5

Gene Ontology (top 5):
GO:0003725 - double-stranded RNA binding
GO:0005634 - nucleus
GO:0005654 - nucleoplasm
GO:0005730 - nucleolus
GO:0005737 - cytoplasm

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1361772

RNC
Ribonuclease 3

14

1

Small-scale

0.983

High

287072

PRKRA
Interferon-inducible double-stranded RNA-dependent protein kinase activator A

2

4

High-throughput

0.811

High

1350994

DDX54
ATP-dependent RNA helicase DDX54

2

4

High-throughput

0.811

High

1361732

DDX27
Probable ATP-dependent RNA helicase DDX27

2

4

High-throughput

0.811

High

1361758

DDX24
ATP-dependent RNA helicase DDX24

2

4

High-throughput

0.811

High

1361764

DDX31
ATP-dependent DNA helicase DDX31

2

5

High-throughput

0.811

High

1361775

STAU2
Double-stranded RNA-binding protein Staufen homolog 2

2

4

High-throughput

0.811

High

1361782

DDX56
Probable ATP-dependent RNA helicase DDX56

2

4

High-throughput

0.811

High

1089768

ILF3
Interleukin enhancer-binding factor 3

2

1

Small-scale

0.789

High

1361725

DDX17
Probable ATP-dependent RNA helicase DDX17

2

2

Small-scale

0.737

High

1361721

DGCR8
Microprocessor complex subunit DGCR8

2

0

Small-scale

0.716

High

346123

STAU1
Double-stranded RNA-binding protein Staufen homolog 1

1

4

High-throughput

0.691

High

1098263

DDX10
Probable ATP-dependent RNA helicase DDX10

1

5

High-throughput

0.691

High

1271468

DHX30
ATP-dependent RNA helicase DHX30

1

1

High-throughput

0.691

High

1361742

DDX50
ATP-dependent RNA helicase DDX50

1

3

High-throughput

0.691

High

1361777

DDX18
ATP-dependent RNA helicase DDX18

1

6

High-throughput

0.691

High

1361738

SRPK1
SRSF protein kinase 1

3

1

High-throughput

0.691

High

1361753

MK67I
MKI67 FHA domain-interacting nucleolar phosphoprotein

3

2

High-throughput

0.662

High

824264

RL13A
Large ribosomal subunit protein uL13

1

0

High-throughput

0.656

High

1006597

SRPK2
SRSF protein kinase 2

3

2

High-throughput

0.650

High

1361787

UBP36
Ubiquitin carboxyl-terminal hydrolase 36

3

1

Small-scale

0.640

High

208326

RRP8
Ribosomal RNA-processing protein 8

3

0

High-throughput

0.634

High

290657

SURF6
Surfeit locus protein 6

3

0

High-throughput

0.634

High

295035

ZN189
Zinc finger protein 189

2

1

High-throughput

0.628

High

517678

ZBT48
Zinc finger and BTB domain-containing protein 48

2

3

High-throughput

0.628

High

600188

ZNF22
Zinc finger protein 22

2

2

High-throughput

0.628

High

601941

ZNF7
Zinc finger protein 7

2

2

High-throughput

0.628

High

1180344

ZN800
Zinc finger protein 800

2

2

High-throughput

0.628

High

1193353

GLYR1
Cytokine-like nuclear factor N-PAC

2

1

High-throughput

0.628

High

1226031

LAR1B
La-related protein 1B

2

1

High-throughput

0.628

High

1230885

Z324B
Zinc finger protein 324B

2

4

High-throughput

0.628

High

1272048

ZN771
Zinc finger protein 771

2

1

High-throughput

0.628

High

1275583

ZCCHV
Zinc finger CCCH-type antiviral protein 1

2

2

High-throughput

0.628

High

1333132

ZFP62
Zinc finger protein 62 homolog

2

1

High-throughput

0.628

High

1336612

PAPD5
Terminal nucleotidyltransferase 4B

2

1

High-throughput

0.628

High

1351427

BRX1
Ribosome biogenesis protein BRX1 homolog

2

4

High-throughput

0.628

High

1353486

ZN483
Zinc finger protein 483

2

3

High-throughput

0.628

High

1361726

RENT1
Regulator of nonsense transcripts 1

2

1

High-throughput

0.628

High

1361730

ZN689
Zinc finger protein 689

2

2

High-throughput

0.628

High

1361735

ZN668
Zinc finger protein 668

2

2

High-throughput

0.628

High

1361751

REPI1
DNA-binding protein REPIN1

2

4

High-throughput

0.628

High

1361767

MOV10
Helicase MOV-10

2

1

High-throughput

0.628

High

1361778

RBM28
RNA-binding protein 28

2

2

High-throughput

0.628

High

1361790

ZNF70
Zinc finger protein 70

2

1

High-throughput

0.628

High

1361796

ZN777
Zinc finger protein 777

2

3

High-throughput

0.628

High

1015268

ERH
Enhancer of rudimentary homolog

3

0

High-throughput

0.622

High

608675

DDX5
Probable ATP-dependent RNA helicase DDX5

1

2

Small-scale

0.618

High

1062567

DHX9
ATP-dependent RNA helicase A

1

1

Small-scale

0.618

High

140611

MPP10
U3 small nucleolar ribonucleoprotein protein MPP10

2

0

High-throughput

0.602

High

188511

NVL
Nuclear valosin-containing protein-like

2

0

High-throughput

0.602

High

257917

DKC1
H/ACA ribonucleoprotein complex subunit DKC1

2

0

High-throughput

0.602

High

338160

NSA2
Ribosome biogenesis protein NSA2 homolog

2

0

High-throughput

0.602

High

355569

NSD2
Histone-lysine N-methyltransferase NSD2

2

0

High-throughput

0.602

High

428460

RLA2
Large ribosomal subunit protein P2

2

0

High-throughput

0.602

High

615895

RL17
Large ribosomal subunit protein uL22

2

0

High-throughput

0.602

High

855153

NOP2
28S rRNA

2

0

High-throughput

0.602

High

904978

MECP2
Methyl-CpG-binding protein 2

2

0

High-throughput

0.602

High

973246

RS13
Small ribosomal subunit protein uS15

2

0

High-throughput

0.602

High

1041839

CENPC
Centromere protein C

2

0

High-throughput

0.602

High

1117619

NOG2
Nucleolar GTP-binding protein 2

2

0

High-throughput

0.602

High

1146515

TTF1
Transcription termination factor 1

2

0

High-throughput

0.602

High

1148132

PUM3
Pumilio homolog 3

2

0

High-throughput

0.602

High

1168540

KNOP1
Lysine-rich nucleolar protein 1

2

0

High-throughput

0.602

High

1244529

SHQ1
Protein SHQ1 homolog

2

0

High-throughput

0.602

High

1245470

CC137
Coiled-coil domain-containing protein 137

2

0

High-throughput

0.602

High

1259004

CENPU
Centromere protein U

2

0

High-throughput

0.602

High

1271981

CENPQ
Centromere protein Q

2

0

High-throughput

0.602

High

1307287

H2A2B
Histone H2A type 2-B

2

0

High-throughput

0.602

High

1314185

SPB1
pre-rRNA 2'-O-ribose RNA methyltransferase FTSJ3

2

0

High-throughput

0.602

High

1356005

NOC3L
Nucleolar complex protein 3 homolog

2

0

High-throughput

0.602

High

1361722

CENPI
Centromere protein I

2

0

High-throughput

0.602

High

1361733

CENPN
Centromere protein N

2

0

High-throughput

0.602

High

1361752

MAK16
Protein MAK16 homolog

2

0

High-throughput

0.602

High

1361754

GTPB4
GTP-binding protein 4

2

0

High-throughput

0.602

High

1361757

REXO4
RNA exonuclease 4

2

0

High-throughput

0.602

High

1361763

RPF2
Ribosome production factor 2 homolog

2

0

High-throughput

0.602

High

1361766

NMNA1
Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 1

2

0

High-throughput

0.602

High

1361779

PK1IP
p21-activated protein kinase-interacting protein 1

2

0

High-throughput

0.602

High

1361794

RALY
RNA-binding protein Raly

2

0

High-throughput

0.602

High

969338

RS8
Small ribosomal subunit protein eS8

2

0

High-throughput

0.576

High

396611

ESR1
Estrogen receptor

2

2

High-throughput

0.571

High

1258100

UBP51
Ubiquitin carboxyl-terminal hydrolase 51

1

1

Small-scale

0.561

High

1129667

MDC1
Mediator of DNA damage checkpoint protein 1

2

0

Small-scale

0.559

High

1361727

FUBP2
Far upstream element-binding protein 2

2

0

Small-scale

0.559

High

1311817

DHX40
Probable ATP-dependent RNA helicase DHX40

1

1

High-throughput

0.553

High

506140

PAB4L
Polyadenylate-binding protein 4-like

2

1

High-throughput

0.552

High

894062

MEOX2
Homeobox protein MOX-2

1

0

High-throughput

0.549

High

1315645

RN168
E3 ubiquitin-protein ligase RNF168

1

0

Small-scale

0.537

High

174445

ZN646
Zinc finger protein 646

1

2

High-throughput

0.536

High

339808

KLF8
Krueppel-like factor 8

1

1

High-throughput

0.536

High

841410

RBM34
RNA-binding protein 34

1

1

High-throughput

0.536

High

886542

CTCF
Transcriptional repressor CTCF

1

4

High-throughput

0.536

High

940157

RRP1
Ribosomal RNA processing protein 1 homolog A

1

1

High-throughput

0.536

High

943723

PRD15
PR domain zinc finger protein 15

1

2

High-throughput

0.536

High

1099461

SRSF6
Serine/arginine-rich splicing factor 6

1

2

High-throughput

0.536

High

1113859

CUL3
Cullin-3

1

1

High-throughput

0.536

High

1130363

RRP1B
Ribosomal RNA processing protein 1 homolog B

1

1

High-throughput

0.536

High

1219417

TUT7
Terminal uridylyltransferase 7

1

1

High-throughput

0.536

High

1234774

ZN770
Zinc finger protein 770

1

2

High-throughput

0.536

High

1245674

LARP1
La-related protein 1

1

1

High-throughput

0.536

High

1308050

ABC3F
DNA dC->dU-editing enzyme APOBEC-3F

1

1

High-throughput

0.536

High

1337474

NGDN
Neuroguidin

1

1

High-throughput

0.536

High

1361731

IMP4
U3 small nucleolar ribonucleoprotein protein IMP4

1

2

High-throughput

0.536

High

1361737

ZN512
Zinc finger protein 512

1

3

High-throughput

0.536

High

1361739

SMC6
Structural maintenance of chromosomes protein 6

1

1

High-throughput

0.536

High

1361745

UTP23
rRNA-processing protein UTP23 homolog

1

1

High-throughput

0.536

High

1361749

HNRL1
Heterogeneous nuclear ribonucleoprotein U-like protein 1

1

1

High-throughput

0.536

High

1361759

GZF1
GDNF-inducible zinc finger protein 1

1

3

High-throughput

0.536

High

1361760

E41LB
Band 4.1-like protein 4B

1

1

High-throughput

0.536

High

1361765

RPF1
Ribosome production factor 1

1

2

High-throughput

0.536

High

1361768

E41L5
Band 4.1-like protein 5

1

1

High-throughput

0.536

High

1361771

SAS10
Something about silencing protein 10

1

1

High-throughput

0.536

High

1361784

CDK12
Cyclin-dependent kinase 12

1

1

High-throughput

0.536

High

1361788

ZN624
Zinc finger protein 624

1

1

High-throughput

0.536

High

1361793

HERC5
E3 ISG15--protein ligase HERC5

1

1

High-throughput

0.536

High

1361802

FCF1
rRNA-processing protein FCF1 homolog

1

1

High-throughput

0.536

High

1361803

RBMX2
RNA-binding motif protein, X-linked 2

1

1

High-throughput

0.536

High

1361808

RBM19
Probable RNA-binding protein 19

1

2

High-throughput

0.536

High

1361809

TLN2
Talin-2

1

2

High-throughput

0.536

High

141025

NOP56
Nucleolar protein 56

1

0

High-throughput

0.513

High

183043

NKRF
NF-kappa-B-repressing factor

1

0

High-throughput

0.513

High

191733

MAGB2
Melanoma-associated antigen B2

1

0

High-throughput

0.513

High

329955

ZWINT
Outer kinetochore KNL1 complex subunit ZWINT

1

0

High-throughput

0.513

High

605525

SYN1
Synapsin-1

1

0

High-throughput

0.513

High

685661

U2AF2
Splicing factor U2AF 65 kDa subunit

1

0

High-throughput

0.513

High

785328

RL4
Large ribosomal subunit protein uL4

1

0

High-throughput

0.513

High

913549

KIF11
Kinesin-like protein KIF11

1

0

High-throughput

0.513

High

975835

RL7A
Large ribosomal subunit protein eL8

1

0

High-throughput

0.513

High

978635

RL23A
Large ribosomal subunit protein uL23

1

0

High-throughput

0.513

High

985263

RL10A
Large ribosomal subunit protein uL1

1

0

High-throughput

0.513

High

1025730

PURA
Transcriptional activator protein Pur-alpha

1

0

High-throughput

0.513

High

1103009

CENPR
Centromere protein R

1

0

High-throughput

0.513

High

1130947

BMS1
Ribosome biogenesis protein BMS1 homolog

1

0

High-throughput

0.513

High

1139979

RRS1
Ribosome biogenesis regulatory protein homolog

1

0

High-throughput

0.513

High

1151165

OASL
2'-5'-oligoadenylate synthase-like protein

1

0

High-throughput

0.513

High

1208787

TDIF2
Deoxynucleotidyltransferase terminal-interacting protein 2

1

0

High-throughput

0.513

High

1210493

HP1B3
Heterochromatin protein 1-binding protein 3

1

0

High-throughput

0.513

High

1228594

SPT2
Protein SPT2 homolog

1

0

High-throughput

0.513

High

1231636

RL7L
Ribosomal protein uL30-like

1

0

High-throughput

0.513

High

1243836

CTR9
RNA polymerase-associated protein CTR9 homolog

1

0

High-throughput

0.513

High

1247272

WDR74
WD repeat-containing protein 74

1

0

High-throughput

0.513

High

1325587

ZCHC7
Zinc finger CCHC domain-containing protein 7

1

0

High-throughput

0.513

High

1360222

SREK1
Splicing regulatory glutamine/lysine-rich protein 1

1

0

High-throughput

0.513

High

1361724

TFG
Protein TFG

1

0

High-throughput

0.513

High

1361729

PINX1
PIN2/TERF1-interacting telomerase inhibitor 1

1

0

High-throughput

0.513

High

1361734

TET5A
Terminal nucleotidyltransferase 5A

1

0

High-throughput

0.513

High

1361736

ZC3HA
Zinc finger CCCH domain-containing protein 10

1

0

High-throughput

0.513

High

1361740

POP1
Ribonucleases P/MRP protein subunit POP1

1

0

High-throughput

0.513

High

1361743

MBB1A
Myb-binding protein 1A

1

0

High-throughput

0.513

High

1361746

TRI56
E3 ubiquitin-protein ligase TRIM56

1

0

High-throughput

0.513

High

1361747

NOL10
Nucleolar protein 10

1

0

High-throughput

0.513

High

1361748

CENPO
Centromere protein O

1

0

High-throughput

0.513

High

1361756

WDR12
Ribosome biogenesis protein WDR12

1

0

High-throughput

0.513

High

1361761

CENPH
Centromere protein H

1

0

High-throughput

0.513

High

1361762

CCD86
Coiled-coil domain-containing protein 86

1

0

High-throughput

0.513

High

1361770

SSF1
Suppressor of SWI4 1 homolog

1

0

High-throughput

0.513

High

1361774

KIF15
Kinesin-like protein KIF15

1

0

High-throughput

0.513

High

1361776

FANCI
Fanconi anemia group I protein

1

0

High-throughput

0.513

High

1361780

KCTD5
BTB/POZ domain-containing protein KCTD5

1

0

High-throughput

0.513

High

1361781

AATF
Protein AATF

1

0

High-throughput

0.513

High

1361785

NOP53
Ribosome biogenesis protein NOP53

1

0

High-throughput

0.513

High

1361786

TAP26
Thyroid transcription factor 1-associated protein 26

1

0

High-throughput

0.513

High

1361789

FBLN5
Fibulin-5

1

0

High-throughput

0.513

High

1361792

RLP24
Probable ribosome biogenesis protein RLP24

1

0

High-throughput

0.513

High

1361798

ABT1
Activator of basal transcription 1

1

0

High-throughput

0.513

High

1361801

NIP7
60S ribosome subunit biogenesis protein NIP7 homolog

1

0

High-throughput

0.513

High

1361805

NOP16
Nucleolar protein 16

1

0

High-throughput

0.513

High

1361806

NOC2L
Nucleolar complex protein 2 homolog

1

0

High-throughput

0.513

High

422741

A4
Amyloid-beta precursor protein

1

0

High-throughput

0.480

High

96733

E9PAV9
G patch domain-containing protein 4

1

1

High-throughput

0.479

High

214880

HNRPR
Heterogeneous nuclear ribonucleoprotein R

1

1

Small-scale

0.479

High

372704

MYC
Myc proto-oncogene protein

1

1

High-throughput

0.479

High

406439

MYCN
N-myc proto-oncogene protein

1

1

High-throughput

0.479

High

472931

RU17
U1 small nuclear ribonucleoprotein 70 kDa

1

1

High-throughput

0.479

High

487583

PARP1
Poly [ADP-ribose] polymerase 1

1

2

Small-scale

0.479

High

530135

TAU
Microtubule-associated protein tau

1

1

High-throughput

0.479

High

535354

BIP
Endoplasmic reticulum chaperone BiP

1

1

Small-scale

0.479

High

558293

XRCC6
X-ray repair cross-complementing protein 6

1

1

Small-scale

0.479

High

559436

XRCC5
X-ray repair cross-complementing protein 5

1

1

Small-scale

0.479

High

620494

NUCL
Nucleolin

1

1

Small-scale

0.479

High

729375

HNRH1
Heterogeneous nuclear ribonucleoprotein H

1

3

Small-scale

0.479

High

765745

BMI1
Polycomb complex protein BMI-1

1

1

High-throughput

0.479

High

775228

FUS
RNA-binding protein FUS

1

1

Small-scale

0.479

High

846643

MSH2
DNA mismatch repair protein Msh2

1

1

Small-scale

0.479

High

913365

MSH6
DNA mismatch repair protein Msh6

1

2

Small-scale

0.479

High

1027627

HNRPU
Heterogeneous nuclear ribonucleoprotein U

1

1

Small-scale

0.479

High

1033094

EWS
RNA-binding protein EWS

1

1

High-throughput

0.479

High

1088931

TP53B
TP53-binding protein 1

1

1

High-throughput

0.479

High

1276556

PARPT
Protein mono-ADP-ribosyltransferase TIPARP

1

1

High-throughput

0.479

High

1313300

SMC5
Structural maintenance of chromosomes protein 5

1

1

High-throughput

0.479

High

1361723

ESR2
Estrogen receptor beta

1

2

High-throughput

0.479

High

1361797

HECD1
E3 ubiquitin-protein ligase HECTD1

1

1

High-throughput

0.479

High

1361807

NR2E1
Nuclear receptor subfamily 2 group E member 1

1

2

Small-scale

0.479

High

132188

WWP2
NEDD4-like E3 ubiquitin-protein ligase WWP2

1

0

High-throughput

0.458

High

163144

CHK1
Serine/threonine-protein kinase Chk1

1

0

Small-scale

0.458

High

302592

RNF8
E3 ubiquitin-protein ligase RNF8

1

0

Small-scale

0.458

High

414308

P53
Cellular tumor antigen p53

1

0

Small-scale

0.458

High

537610

HSP7C
Heat shock cognate 71 kDa protein

1

0

Small-scale

0.458

High

551177

PCNA
Proliferating cell nuclear antigen

1

0

Small-scale

0.458

High

696067

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

0

Small-scale

0.458

High

703666

MK01
Mitogen-activated protein kinase 1

1

0

High-throughput

0.458

High

714928

EF1D
Elongation factor 1-delta

1

0

High-throughput

0.458

High

810251

RL3
Large ribosomal subunit protein uL3

1

0

High-throughput

0.458

High

814553

FEN1
Flap endonuclease 1

1

0

Small-scale

0.458

High

842816

CDN2A
Cyclin-dependent kinase inhibitor 2A

1

0

High-throughput

0.458

High

872584

SOX2
Transcription factor SOX-2

1

0

High-throughput

0.458

High

1007743

RAE1L
mRNA export factor RAE1

1

0

High-throughput

0.458

High

1008261

PRKDC
DNA-dependent protein kinase catalytic subunit

1

0

Small-scale

0.458

High

1157834

DDB1
DNA damage-binding protein 1

1

0

Small-scale

0.458

High

1199928

P5CR3
Pyrroline-5-carboxylate reductase 3

1

0

High-throughput

0.458

High

1287862

MTA70
N(6)-adenosine-methyltransferase catalytic subunit METTL3

1

0

Small-scale

0.458

High

1326498

ARL14
ADP-ribosylation factor-like protein 14

1

0

High-throughput

0.458

High

1360108

NALP7
NACHT, LRR and PYD domains-containing protein 7

1

0

High-throughput

0.458

High

1361728

RL36L
Ribosomal protein eL42-like

1

0

High-throughput

0.458

High

1361741

ANM1
Protein arginine N-methyltransferase 1

1

0

High-throughput

0.458

High

1361750

DDA1
DET1- and DDB1-associated protein 1

1

0

High-throughput

0.458

High

1361755

UBE2O
(E3-independent) E2 ubiquitin-conjugating enzyme

1

0

High-throughput

0.458

High

1361783

TE2IP
Telomeric repeat-binding factor 2-interacting protein 1

1

0

High-throughput

0.458

High

1361791

ZRAN1
Ubiquitin thioesterase ZRANB1

1

0

High-throughput

0.458

High

1361799

PRP19
Pre-mRNA-processing factor 19

1

0

Small-scale

0.458

High

1361773

ABC3C
DNA dC->dU-editing enzyme APOBEC-3C

1

1

High-throughput

0.445

High

288718

NPM3
Nucleoplasmin-3

1

0

High-throughput

0.426

High

900435

FXR2
RNA-binding protein FXR2

1

0

High-throughput

0.426

High

985788

RL11
Large ribosomal subunit protein uL5

1

0

High-throughput

0.426

High

1161335

HIF1A
Hypoxia-inducible factor 1-alpha

1

0

Small-scale

0.426

High

1328508

RNF10
E3 ubiquitin-protein ligase RNF10

1

0

High-throughput

0.426

High

1340180

ARK74
Aflatoxin B1 aldehyde reductase member 4

1

0

High-throughput

0.426

High

1361795

ZN346
Zinc finger protein 346

1

0

High-throughput

0.426

High

69963

A8KAG1
G patch domain-containing protein 4

1

1

High-throughput

0.407

High

1361800

RL26L
Ribosomal protein uL24-like

3

0

High-throughput

0.339

High

354028

CX001
Putative transmembrane protein CXorf1

1

0

High-throughput

0.279

Low

1127449

FGFP1
Fibroblast growth factor-binding protein 1

1

0

High-throughput

0.279

Low

1330665

BEND7
BEN domain-containing protein 7

1

0

High-throughput

0.279

Low

1350797

RS4Y2
Small ribosomal subunit protein eS4, Y isoform 2

1

0

High-throughput

0.279

Low

1361744

CHOLN
Protein cholesin

1

0

High-throughput

0.279

Low

1361769

LUC7L
Putative RNA-binding protein Luc7-like 1

1

0

High-throughput

0.279

Low

1361804

RRP15
RRP15-like protein

1

0

High-throughput

0.279

Low

1290405

LRRT4
Leucine-rich repeat transmembrane neuronal protein 4

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025