HitPredict

Interactor 1: PSMD2 (Q13200)
26S proteasome non-ATPase regulatory subunit 2 (26S proteasome regulatory subunit RPN1) (26S proteasome regulatory subunit S2) (26S proteasome subunit p97) (Protein 55.11) (Tumor necrosis factor type 1 receptor-associated protein 2)
Gene: PSMD2

Interactor 2: PSMD1 (Q99460)
26S proteasome non-ATPase regulatory subunit 1 (26S proteasome regulatory subunit RPN2) (26S proteasome regulatory subunit S1) (26S proteasome subunit p112)
Gene: PSMD1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.77	1.00	0.879

The method score is based on:

Property	Details
Experiments	35271311, 28292943, 33961781
Identification Methods	affinity chromatography technology, pull down, anti tag coimmunoprecipitation
Interaction Type	physical association, direct interaction, association

The annotation score is based on:

Property	Details
Interacting Pfam domains	PC_rep~PC_rep, PC_rep~RPN1_RPN2_N, RPN1_RPN2_N~RPN2_C
Common GO terms	GO:0000502 - proteasome complex GO:0005576 - extracellular region GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005829 - cytosol and 8 others more... GO:0005838 - proteasome regulatory particle GO:0008540 - proteasome regulatory particle, base subcomplex GO:0016020 - membrane GO:0022624 - proteasome accessory complex GO:0030234 - enzyme regulator activity GO:0034515 - proteasome storage granule GO:0042176 - regulation of protein catabolic process GO:0043161 - proteasome-mediated ubiquitin-dependent protein catabolic process
Homologous interactions	10

Homologous interactions

Color coding for hit scores

	1	908
Hs

1	953

Service provided by Combinatics, Japan

Last updated: 15 Jul 2024