Protein: RNC
Ribonuclease 3 (EC 3.1.26.3) (Protein Drosha) (Ribonuclease III) (RNase III) (p241)

Gene: RNC, DROSHA
Organism: Homo sapiens
Interactions: 178
UniProt ID: Q9NRR4

Gene Ontology (top 5):
GO:0001530 - lipopolysaccharide binding
GO:0003723 - RNA binding
GO:0004525 - ribonuclease III activity
GO:0005634 - nucleus
GO:0005654 - nucleoplasm

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1361772

DGCR8
Microprocessor complex subunit DGCR8

14

1

Small-scale

0.983

High

608766

DDX5
Probable ATP-dependent RNA helicase DDX5

5

7

Small-scale

0.919

High

1369405

DDX17
Probable ATP-dependent RNA helicase DDX17

4

7

Small-scale

0.875

High

1089892

ILF3
Interleukin enhancer-binding factor 3

2

10

High-throughput

0.789

High

1402604

SRPK1
SRSF protein kinase 1

5

7

High-throughput

0.718

High

414695

P53
Cellular tumor antigen p53

3

4

Small-scale

0.656

High

1370858

FUBP2
Far upstream element-binding protein 2

3

13

Small-scale

0.640

High

1006741

SRPK2
SRSF protein kinase 2

2

8

High-throughput

0.628

High

838799

MTREX
Exosome RNA helicase MTR4

1

11

High-throughput

0.618

High

937354

DSRAD
Double-stranded RNA-specific adenosine deaminase

1

20

Small-scale

0.618

High

1311869

DHX40
Probable ATP-dependent RNA helicase DHX40

1

8

High-throughput

0.618

High

594113

NCK1
SH2/SH3 adapter protein NCK1

2

2

High-throughput

0.611

High

775332

FUS
RNA-binding protein FUS

2

14

Small-scale

0.601

High

1015318

ERH
Enhancer of rudimentary homolog

2

1

High-throughput

0.601

High

1116042

DYR1A
Dual specificity tyrosine-phosphorylation-regulated kinase 1A

1

2

High-throughput

0.590

High

129466

MEN1
Menin

2

2

High-throughput

0.584

High

485448

ROA1
Heterogeneous nuclear ribonucleoprotein A1

2

13

High-throughput

0.584

High

888676

YLPM1
YLP motif-containing protein 1

2

7

High-throughput

0.584

High

1059979

KHDR1
KH domain-containing, RNA-binding, signal transduction-associated protein 1

2

4

High-throughput

0.584

High

1399761

RBM14
RNA-binding protein 14

2

9

High-throughput

0.584

High

1406863

ROAA
Heterogeneous nuclear ribonucleoprotein A/B

2

14

High-throughput

0.584

High

1448772

RNC
Ribonuclease 3

1

16

Small-scale

0.575

High

397026

ESR1
Estrogen receptor

2

12

High-throughput

0.571

High

1154012

SMAD1
Mothers against decapentaplegic homolog 1

1

3

Small-scale

0.554

High

279513

TULP3
Tubby-related protein 3

1

1

High-throughput

0.541

High

74619

HNRC2
Heterogeneous nuclear ribonucleoprotein C-like 2

1

8

High-throughput

0.536

High

191827

MAGB2
Melanoma-associated antigen B2

1

2

High-throughput

0.536

High

696615

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

6

High-throughput

0.536

High

832811

BCL6
B-cell lymphoma 6 protein

1

1

Small-scale

0.536

High

1052914

HME1
Homeobox protein engrailed-1

1

4

High-throughput

0.536

High

1065450

SSRP1
FACT complex subunit SSRP1

1

5

High-throughput

0.536

High

1114406

CUL3
Cullin-3

1

5

High-throughput

0.536

High

1161412

HIF1A
Hypoxia-inducible factor 1-alpha

1

2

Small-scale

0.536

High

1406697

SMAD5
Mothers against decapentaplegic homolog 5

1

3

Small-scale

0.536

High

1407424

EPAS1
Endothelial PAS domain-containing protein 1

1

2

Small-scale

0.536

High

1435340

EGLN3
Prolyl hydroxylase EGLN3

1

1

High-throughput

0.536

High

1448777

ZNFX1
NFX1-type zinc finger-containing protein 1

1

5

High-throughput

0.536

High

1448781

LCAP
Leucyl-cystinyl aminopeptidase

1

1

High-throughput

0.536

High

1448786

ABT1
Activator of basal transcription 1

1

1

High-throughput

0.536

High

1448788

SRPK3
SRSF protein kinase 3

1

7

High-throughput

0.536

High

655349

SFPQ
Splicing factor, proline- and glutamine-rich

1

7

High-throughput

0.515

High

1204398

SGO1
Shugoshin 1

1

0

High-throughput

0.513

High

1396137

Z512B
Zinc finger protein 512B

1

6

High-throughput

0.508

High

1014634

SMAD3
Mothers against decapentaplegic homolog 3

1

3

Small-scale

0.500

High

132324

WWP2
NEDD4-like E3 ubiquitin-protein ligase WWP2

1

3

High-throughput

0.479

High

163835

TCRG1
Transcription elongation regulator 1

1

7

High-throughput

0.479

High

172234

HNRDL
Heterogeneous nuclear ribonucleoprotein D-like

1

15

High-throughput

0.479

High

173427

XPO1
Exportin-1

1

4

High-throughput

0.479

High

174620

TRI66
Tripartite motif-containing protein 66

1

5

High-throughput

0.479

High

175791

SR140
U2 snRNP-associated SURP motif-containing protein

1

5

High-throughput

0.479

High

214958

HNRPR
Heterogeneous nuclear ribonucleoprotein R

1

9

High-throughput

0.479

High

223563

ZN207
BUB3-interacting and GLEBS motif-containing protein ZNF207

1

5

High-throughput

0.479

High

229087

AKAP8
A-kinase anchor protein 8

1

3

High-throughput

0.479

High

250860

HNRPQ
Heterogeneous nuclear ribonucleoprotein Q

1

9

High-throughput

0.479

High

276530

PDCD6
Programmed cell death protein 6

1

2

High-throughput

0.479

High

280837

PR40A
Pre-mRNA-processing factor 40 homolog A

1

9

High-throughput

0.479

High

297034

CCNK
Cyclin-K

1

5

High-throughput

0.479

High

321877

PCF11
Pre-mRNA cleavage complex 2 protein Pcf11

1

2

High-throughput

0.479

High

326382

SCAF4
SR-related and CTD-associated factor 4

1

8

High-throughput

0.479

High

333795

CELF2
CUGBP Elav-like family member 2

1

6

High-throughput

0.479

High

401554

RAF1
RAF proto-oncogene serine/threonine-protein kinase

1

4

High-throughput

0.479

High

462668

HNRPC
Heterogeneous nuclear ribonucleoproteins C1/C2

1

11

High-throughput

0.479

High

465044

SP1
Transcription factor Sp1

1

4

Small-scale

0.479

High

480320

RU1C
U1 small nuclear ribonucleoprotein C

1

3

High-throughput

0.479

High

576572

HNRPL
Heterogeneous nuclear ribonucleoprotein L

1

9

High-throughput

0.479

High

650983

ROA2
Heterogeneous nuclear ribonucleoproteins A2/B1

1

12

High-throughput

0.479

High

685747

U2AF2
Splicing factor U2AF 65 kDa subunit

1

6

High-throughput

0.479

High

729133

HNRH3
Heterogeneous nuclear ribonucleoprotein H3

1

10

High-throughput

0.479

High

729473

HNRH1
Heterogeneous nuclear ribonucleoprotein H

1

10

High-throughput

0.479

High

765920

BMI1
Polycomb complex protein BMI-1

1

5

High-throughput

0.479

High

794642

RBMX
RNA-binding motif protein, X chromosome

1

7

High-throughput

0.479

High

846492

MATR3
Matrin-3

1

5

High-throughput

0.479

High

889208

RBM25
RNA-binding protein 25

1

6

High-throughput

0.479

High

905181

MECP2
Methyl-CpG-binding protein 2

1

5

High-throughput

0.479

High

909715

ROA3
Heterogeneous nuclear ribonucleoprotein A3

1

15

High-throughput

0.479

High

910703

HNRPM
Heterogeneous nuclear ribonucleoprotein M

1

5

High-throughput

0.479

High

913064

HNRPF
Heterogeneous nuclear ribonucleoprotein F

1

10

High-throughput

0.479

High

913993

RBM5
RNA-binding protein 5

1

7

High-throughput

0.479

High

971147

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

3

High-throughput

0.479

High

987969

GRB2
Growth factor receptor-bound protein 2

1

3

High-throughput

0.479

High

1005507

RBM6
RNA-binding protein 6

1

8

High-throughput

0.479

High

1023180

RBM10
RNA-binding protein 10

1

7

High-throughput

0.479

High

1024867

VIGLN
Vigilin

1

13

High-throughput

0.479

High

1028409

MDM2
E3 ubiquitin-protein ligase Mdm2

1

1

Small-scale

0.479

High

1029043

TIAR
Nucleolysin TIAR

1

4

High-throughput

0.479

High

1033259

EWS
RNA-binding protein EWS

1

11

High-throughput

0.479

High

1035941

KIF23
Kinesin-like protein KIF23

1

5

High-throughput

0.479

High

1095598

LIPA1
Liprin-alpha-1

1

1

High-throughput

0.479

High

1096240

TADBP
TAR DNA-binding protein 43

1

9

High-throughput

0.479

High

1096407

ROA0
Heterogeneous nuclear ribonucleoprotein A0

1

14

High-throughput

0.479

High

1099045

SRSF9
Serine/arginine-rich splicing factor 9

1

8

High-throughput

0.479

High

1119709

CDK13
Cyclin-dependent kinase 13

1

1

High-throughput

0.479

High

1120361

HNRPD
Heterogeneous nuclear ribonucleoprotein D0

1

14

High-throughput

0.479

High

1127186

RBM39
RNA-binding protein 39

1

5

High-throughput

0.479

High

1150829

SF01
Splicing factor 1

1

7

High-throughput

0.479

High

1152653

ELAV1
ELAV-like protein 1

1

4

High-throughput

0.479

High

1160100

SRSF7
Serine/arginine-rich splicing factor 7

1

12

High-throughput

0.479

High

1160316

CPSF6
Cleavage and polyadenylation specificity factor subunit 6

1

12

High-throughput

0.479

High

1168904

HNRL2
Heterogeneous nuclear ribonucleoprotein U-like protein 2

1

9

High-throughput

0.479

High

1203623

ZN326
DBIRD complex subunit ZNF326

1

3

High-throughput

0.479

High

1212653

RBM20
RNA-binding protein 20

1

5

High-throughput

0.479

High

1220835

RN123
E3 ubiquitin-protein ligase RNF123

1

9

High-throughput

0.479

High

1248085

FIP1
Pre-mRNA 3'-end-processing factor FIP1

1

2

High-throughput

0.479

High

1253715

CO039
Uncharacterized protein C15orf39

1

5

High-throughput

0.479

High

1260299

HAKAI
E3 ubiquitin-protein ligase Hakai

1

4

High-throughput

0.479

High

1279911

RBBP6
E3 ubiquitin-protein ligase RBBP6

1

9

High-throughput

0.479

High

1290755

ZCH18
Zinc finger CCCH domain-containing protein 18

1

10

High-throughput

0.479

High

1293423

CARM1
Histone-arginine methyltransferase CARM1

1

4

High-throughput

0.479

High

1311291

CHERP
Calcium homeostasis endoplasmic reticulum protein

1

4

High-throughput

0.479

High

1311735

CCAR1
Cell division cycle and apoptosis regulator protein 1

1

2

High-throughput

0.479

High

1312940

RB12B
RNA-binding protein 12B

1

14

High-throughput

0.479

High

1314159

RAVR1
Ribonucleoprotein PTB-binding 1

1

8

High-throughput

0.479

High

1323167

CCAR2
Cell cycle and apoptosis regulator protein 2

1

1

High-throughput

0.479

High

1329125

CPSF7
Cleavage and polyadenylation specificity factor subunit 7

1

8

High-throughput

0.479

High

1338774

ARI1B
AT-rich interactive domain-containing protein 1B

1

7

High-throughput

0.479

High

1346944

SNIP1
Smad nuclear-interacting protein 1

1

1

Small-scale

0.479

High

1352776

DOT1L
Histone-lysine N-methyltransferase, H3 lysine-79 specific

1

1

High-throughput

0.479

High

1360124

NALP7
NACHT, LRR and PYD domains-containing protein 7

1

1

High-throughput

0.479

High

1360498

PSPC1
Paraspeckle component 1

1

9

High-throughput

0.479

High

1367373

ESR2
Estrogen receptor beta

1

11

High-throughput

0.479

High

1368899

RBP56
TATA-binding protein-associated factor 2N

1

9

High-throughput

0.479

High

1382848

FUBP1
Far upstream element-binding protein 1

1

12

High-throughput

0.479

High

1389465

DAZP1
DAZ-associated protein 1

1

12

High-throughput

0.479

High

1389770

RBM33
RNA-binding protein 33

1

9

High-throughput

0.479

High

1393965

FUBP3
Far upstream element-binding protein 3

1

13

High-throughput

0.479

High

1394014

SPF45
Splicing factor 45

1

3

High-throughput

0.479

High

1396366

ZFR
Zinc finger RNA-binding protein

1

8

High-throughput

0.479

High

1400075

QKI
KH domain-containing RNA-binding protein QKI

1

4

High-throughput

0.479

High

1400257

LENG8
Leukocyte receptor cluster member 8

1

6

High-throughput

0.479

High

1400886

GCNA
Germ cell nuclear acidic protein

1

1

High-throughput

0.479

High

1408341

PKP2
Plakophilin-2

1

3

High-throughput

0.479

High

1414343

HNRL1
Heterogeneous nuclear ribonucleoprotein U-like protein 1

1

9

High-throughput

0.479

High

1415877

DDA1
DET1- and DDB1-associated protein 1

1

1

High-throughput

0.479

High

1417064

PINK1
Serine/threonine-protein kinase PINK1, mitochondrial

1

3

High-throughput

0.479

High

1421320

WDR33
pre-mRNA 3' end processing protein WDR33

1

3

High-throughput

0.479

High

1429800

XRN2
5'-3' exoribonuclease 2

1

1

High-throughput

0.479

High

1435157

ESRP2
Epithelial splicing regulatory protein 2

1

10

High-throughput

0.479

High

1435897

ZN703
Zinc finger protein 703

1

3

High-throughput

0.479

High

1438835

NCOA5
Nuclear receptor coactivator 5

1

1

High-throughput

0.479

High

1448773

RBM12
RNA-binding protein 12

1

10

High-throughput

0.479

High

1448774

RBM22
Pre-mRNA-splicing factor RBM22

1

5

High-throughput

0.479

High

1448775

WWOX
WW domain-containing oxidoreductase

1

1

High-throughput

0.479

High

1448776

UBP36
Ubiquitin carboxyl-terminal hydrolase 36

1

3

Small-scale

0.479

High

1448778

RBM27
RNA-binding protein 27

1

3

High-throughput

0.479

High

1448780

XPO7
Exportin-7

1

3

High-throughput

0.479

High

1448782

PTBP2
Polypyrimidine tract-binding protein 2

1

5

High-throughput

0.479

High

1448783

GPTC8
G patch domain-containing protein 8

1

6

High-throughput

0.479

High

1448784

RALY
RNA-binding protein Raly

1

4

High-throughput

0.479

High

1448785

HECD1
E3 ubiquitin-protein ligase HECTD1

1

6

High-throughput

0.479

High

1448787

AKP8L
A-kinase anchor protein 8-like

1

3

High-throughput

0.479

High

1448789

SCAF8
SR-related and CTD-associated factor 8

1

5

High-throughput

0.479

High

1448790

ZC3H4
Zinc finger CCCH domain-containing protein 4

1

9

High-throughput

0.479

High

1448792

TR150
Thyroid hormone receptor-associated protein 3

1

11

High-throughput

0.479

High

1448793

WBP11
WW domain-binding protein 11

1

2

High-throughput

0.479

High

1448794

NR2E1
Nuclear receptor subfamily 2 group E member 1

1

9

Small-scale

0.479

High

183087

NKRF
NF-kappa-B-repressing factor

1

0

High-throughput

0.458

High

228379

CPSF5
Cleavage and polyadenylation specificity factor subunit 5

1

0

High-throughput

0.458

High

257979

DKC1
H/ACA ribonucleoprotein complex subunit DKC1

1

0

High-throughput

0.458

High

330517

LC7L3
Luc7-like protein 3

1

0

High-throughput

0.458

High

963234

LYSC
Lysozyme C

1

0

High-throughput

0.458

High

1199041

KLH12
Kelch-like protein 12

1

0

High-throughput

0.458

High

1218229

ZN318
Zinc finger protein 318

1

0

High-throughput

0.458

High

1240270

ZCHC8
Zinc finger CCHC domain-containing protein 8

1

0

High-throughput

0.458

High

1272122

RSRC2
Arginine/serine-rich coiled-coil protein 2

1

0

High-throughput

0.458

High

1281092

KHDC4
KH homology domain-containing protein 4

1

0

High-throughput

0.458

High

1367747

PRCC
Proline-rich protein PRCC

1

0

High-throughput

0.458

High

1417820

PDIP3
Polymerase delta-interacting protein 3

1

0

High-throughput

0.458

High

947375

NAL12
NACHT, LRR and PYD domains-containing protein 12

1

2

Small-scale

0.457

High

900530

FXR2
RNA-binding protein FXR2

1

8

High-throughput

0.445

High

1110114

HDAC1
Histone deacetylase 1

1

2

Small-scale

0.445

High

1368143

HDAC2
Histone deacetylase 2

1

2

Small-scale

0.445

High

1063878

LG3BP
Galectin-3-binding protein

1

3

High-throughput

0.437

High

1130668

GSE1
Genetic suppressor element 1

1

1

High-throughput

0.437

High

1448779

ACHA9
Neuronal acetylcholine receptor subunit alpha-9

3

0

High-throughput

0.347

High

1448791

CLC11
C-type lectin domain family 11 member A

1

0

High-throughput

0.279

Low

866448

CASA1
Alpha-S1-casein [Cleaved into: Casoxin-D]

1

0

High-throughput

0.249

Low

1231579

TBC3G
TBC1 domain family member 3G

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025