HitPredict

Interactor 1: PSMD2 (Q13200)
26S proteasome non-ATPase regulatory subunit 2 (26S proteasome regulatory subunit RPN1) (26S proteasome regulatory subunit S2) (26S proteasome subunit p97) (Protein 55.11) (Tumor necrosis factor type 1 receptor-associated protein 2)
Gene: PSMD2

Interactor 2: CHIP (Q9UNE7)
E3 ubiquitin-protein ligase CHIP (EC 2.3.2.27) (Antigen NY-CO-7) (CLL-associated antigen KW-8) (Carboxy terminus of Hsp70-interacting protein) (RING-type E3 ubiquitin transferase CHIP) (STIP1 homology and U box-containing protein 1)
Gene: STUB1

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.58	0.60	0.595

Property	Details
Experiments	32723828, 25036637
Identification Methods	enzymatic study, luminescence based mammalian interactome mapping
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005829 - cytosol GO:0043161 - proteasome-mediated ubiquitin-dependent protein catabolic process
Homologous interactions	3

Homologous interactions

Color coding for hit scores

	1 908 Hs			1 303
+	Hs
		1027771 PSMD2_HUMAN (1-908): 0: 1290: 100.00		Q9BPW0_HUMAN (1-259): 2.98e-36: 137: 20.91
+	Hs
		213540 PSMD2_HUMAN (1-908): 0: 1290: 100.00		SGTA_HUMAN (3-140): 2.4e-33: 126: 29.71
+	Hs
		1303955 PSMD1_HUMAN (59-845): 0: 790: 17.31		CHIP_HUMAN (1-303): 3.8e-69: 218: 100.00