HitPredict - High confidence protein-protein interactions

Interactor 1: ERCC8 (Q13216)
DNA excision repair protein ERCC-8 (Cockayne syndrome WD repeat protein CSA)
Gene: ERCC8

Interactor 2: ERCC8 (Q13216)
DNA excision repair protein ERCC-8 (Cockayne syndrome WD repeat protein CSA)
Gene: ERCC8

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.58	1.00	0.768

Property	Details
Experiments	34581821, 34526721
Identification Methods	affinity chromatography technology, enzymatic study
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	WD40~WD40
Common GO terms	GO:0000012 - single strand break repair GO:0000109 - nucleotide-excision repair complex GO:0000209 - protein polyubiquitination GO:0005634 - nucleus GO:0005654 - nucleoplasm and 15 others more... GO:0006283 - transcription-coupled nucleotide-excision repair GO:0006974 - DNA damage response GO:0006979 - response to oxidative stress GO:0009411 - response to UV GO:0010165 - response to X-ray GO:0016363 - nuclear matrix GO:0031464 - Cul4A-RING E3 ubiquitin ligase complex GO:0032991 - protein-containing complex GO:0043161 - proteasome-mediated ubiquitin-dependent protein catabolic process GO:0044877 - protein-containing complex binding GO:0045739 - positive regulation of DNA repair GO:0051865 - protein autoubiquitination GO:0080008 - Cul4-RING E3 ubiquitin ligase complex GO:0090262 - regulation of transcription-coupled nucleotide-excision repair GO:0097680 - double-strand break repair via classical nonhomologous end joining
Homologous interactions	17

Homologous interactions

Color coding for hit scores

	1	396
Hs

1	396

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Last updated: 15 Jul 2024