HitPredict

Interactor 1: NMDE2 (Q13224)
Glutamate receptor ionotropic, NMDA 2B (GluN2B) (Glutamate [NMDA] receptor subunit epsilon-2) (N-methyl D-aspartate receptor subtype 2B) (NMDAR2B) (NR2B) (N-methyl-D-aspartate receptor subunit 3) (NR3) (hNR3)
Gene: GRIN2B

Interactor 2: KCC2A (Q9UQM7)
Calcium/calmodulin-dependent protein kinase type II subunit alpha (CaM kinase II subunit alpha) (CaMK-II subunit alpha) (EC 2.7.11.17)
Gene: CAMK2A

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.82	0.60	0.702

Property	Details
Experiments	16436603, 9694809, 11459059, 19453375
Identification Methods	pull down, affinity chromatography technology, competition binding
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0014069 - postsynaptic density GO:0043005 - neuron projection GO:0048168 - regulation of neuronal synaptic plasticity
Homologous interactions	15

Homologous interactions

Color coding for hit scores

	1 1484 Hs			1 478
+	Rn
		506719 NMDE2_RAT (1-1484): 0: 1829: 98.45		KCC2A_RAT (1-478): 0: 566: 99.79
+	Mm
		515226 NMDE2_MOUSE (1-1484): 0: 1826: 98.45		KCC2A_MOUSE (1-478): 0: 566: 99.79
+	Rn
		550161 NMDE2_RAT (1-1484): 0: 1829: 98.45		KCC2D_RAT (2-476): 0: 537: 80.32
+	Mm
		659449 NMDE2_MOUSE (1-1484): 0: 1826: 98.45		KCC2B_MOUSE (1-476): 6.17e-179: 514: 71.11
+	Rn
		506718 NMDE1_RAT (9-1484): 0: 1506: 52.59		KCC2A_RAT (1-478): 0: 566: 99.79
+	Rn
		550160 NMDE1_RAT (9-1484): 0: 1506: 52.59		KCC2D_RAT (2-476): 0: 537: 80.32
+	Hs
		1028136 NMDE2_HUMAN (1-1484): 0: 1846: 100.00		KCC2G_HUMAN (276-475): 3.97e-45: 167: 53.50
+	Rn
		506693 GRIA1_RAT (11-901): 0: 693: 19.48		KCC2A_RAT (1-478): 0: 566: 99.79
+	Hs
		786716 GRIA1_HUMAN (16-901): 0: 690: 19.56		KCC2A_HUMAN (1-478): 0: 565: 100.00
+	Mm
		515217 NMDZ1_MOUSE (14-940): 0: 671: 23.52		KCC2A_MOUSE (1-478): 0: 566: 99.79
+	Hs
		984288 NMDZ1_HUMAN (13-940): 0: 668: 23.60		KCC2A_HUMAN (1-478): 0: 565: 100.00
+	Hs
		816227 GRIA4_HUMAN (17-852): 0: 660: 20.89		KCC2A_HUMAN (1-478): 0: 565: 100.00
+	Mm
		659444 NMDZ1_MOUSE (14-940): 0: 671: 23.52		KCC2B_MOUSE (1-476): 6.17e-179: 514: 71.11
+	Rn
		514948 GRIA4_RAT (17-852): 0: 658: 20.89		KCC2G_RAT (1-476): 0: 522: 76.00
+	Hs
		984259 NMDZ1_HUMAN (13-940): 0: 668: 23.60		KCC2G_HUMAN (276-475): 3.97e-45: 167: 53.50