HitPredict

Interactor 1: SRSF5 (Q13243)
Serine/arginine-rich splicing factor 5 (Delayed-early protein HRS) (Pre-mRNA-splicing factor SRP40) (Splicing factor, arginine/serine-rich 5)
Gene: SRSF5

Interactor 2: SRSF7 (Q16629)
Serine/arginine-rich splicing factor 7 (Splicing factor 9G8) (Splicing factor, arginine/serine-rich 7)
Gene: SRSF7

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	1.00	0.691

Property	Details
Experiments	33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	RRM_1~RRM_1
Common GO terms	GO:0000398 - mRNA splicing, via spliceosome GO:0003723 - RNA binding GO:0003729 - mRNA binding GO:0005654 - nucleoplasm GO:0006397 - mRNA processing and 1 others more... GO:0016607 - nuclear speck
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 272 Hs			1 238
+	At
		1163070 SR30_ARATH (6-191): 3.33e-56: 183: 34.38		CYP59_ARATH (1-204): 1.62e-28: 114: 17.14
+	Hs
		992790 SRSF1_HUMAN (2-170): 6.55e-57: 184: 43.68		SRSF7_HUMAN (1-238): 6.03e-28: 108: 100.00
+	Hs
		992863 SRSF1_HUMAN (2-170): 6.55e-57: 184: 43.68		SRS12_HUMAN (1-218): 8.5e-28: 108: 32.60
+	Hs
		1028744 SRSF5_HUMAN (1-240): 2.63e-54: 178: 100.00		ZCRB1_HUMAN (7-221): 2.04e-28: 108: 22.73
+	Hs
		993726 SRSF4_HUMAN (5-265): 3.78e-51: 176: 53.64		SRSF7_HUMAN (1-238): 6.03e-28: 108: 100.00
+	Hs
		993776 SRSF4_HUMAN (5-265): 3.78e-51: 176: 53.64		ZCRB1_HUMAN (7-221): 2.04e-28: 108: 22.73
+	Hs
		993783 SRSF4_HUMAN (5-265): 3.78e-51: 176: 53.64		SRS12_HUMAN (1-218): 8.5e-28: 108: 32.60
+	Hs
		432668 SRSF1_HUMAN (2-170): 6.55e-57: 184: 43.68		HNRPC_HUMAN (3-186): 3e-24: 99: 22.58
+	Hs
		951932 SRSF1_HUMAN (2-170): 6.55e-57: 184: 43.68		SRSF3_HUMAN (5-154): 2.52e-24: 96.5: 55.33
+	At
		1352382 SR30_ARATH (6-191): 3.33e-56: 183: 34.38		RZ22A_ARATH (11-192): 6.24e-24: 96.5: 33.33
+	Hs
		432685 SRSF5_HUMAN (1-240): 2.63e-54: 178: 100.00		HNRPC_HUMAN (3-186): 3e-24: 99: 22.58
+	Hs
		951941 SRSF5_HUMAN (1-240): 2.63e-54: 178: 100.00		SRSF3_HUMAN (5-154): 2.52e-24: 96.5: 55.33
+	Hs
		992736 SRSF1_HUMAN (2-170): 6.55e-57: 184: 43.68		SRSF1_HUMAN (10-81): 4.51e-21: 90.3: 48.65
+	Hs
		951933 SRSF4_HUMAN (5-265): 3.78e-51: 176: 53.64		SRSF3_HUMAN (5-154): 2.52e-24: 96.5: 55.33
+	Hs
		516478 SRSF1_HUMAN (2-170): 6.55e-57: 184: 43.68		PABP1_HUMAN (6-97): 2.16e-19: 88.2: 22.11
+	Dm
		1097969 Q9V3W7_DROME (2-190): 8.5e-55: 179: 36.27		RX21_DROME (11-166): 3.13e-21: 89.6: 33.51
+	Hs
		992751 SRSF5_HUMAN (1-240): 2.63e-54: 178: 100.00		SRSF1_HUMAN (10-81): 4.51e-21: 90.3: 48.65
+	Hs
		992737 SRSF4_HUMAN (5-265): 3.78e-51: 176: 53.64		SRSF1_HUMAN (10-81): 4.51e-21: 90.3: 48.65
+	Mm
		936481 SRSF1_MOUSE (2-170): 6.55e-57: 184: 43.68		TIAR_MOUSE (5-97): 1.01e-13: 71.3: 23.01
+	Mm
		1208011 SRSF9_MOUSE (2-211): 1.94e-54: 177: 34.42		RBM4_MOUSE (12-89): 2.3e-14: 73.3: 33.33