Protein: LAC1
Ceramide synthase LAC1 (Very-long-chain ceramide synthase LAC1) (EC 2.3.1.297)

Gene: LAC1
Organism: Saccharomyces cerevisiae S288C
Interactions: 99
UniProt ID: P28496

Gene Ontology (top 5):
GO:0005783 - endoplasmic reticulum
GO:0005789 - endoplasmic reticulum membrane
GO:0034399 - nuclear periphery
GO:0046513 - ceramide biosynthetic process
GO:0050291 - sphingosine N-acyltransferase activity

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

659156

LAG1
Ceramide synthase LAG1

5

6

Small-scale

0.724

High

659188

LIP1
Ceramide synthase subunit LIP1

4

1

Small-scale

0.706

High

659144

OSTB
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit WBP1

2

1

High-throughput

0.614

High

659147

YET1
Endoplasmic reticulum transmembrane protein 1

2

5

High-throughput

0.614

High

659151

PHO88
SRP-independent targeting protein 3

2

1

High-throughput

0.614

High

659164

ELO3
Fatty acid elongase 3

2

8

High-throughput

0.614

High

659132

LAC1
Ceramide synthase LAC1

2

6

High-throughput

0.613

High

495798

CP51
Lanosterol 14-alpha demethylase CYP51

2

0

High-throughput

0.605

High

630708

AGP1
General amino acid permease AGP1

1

3

High-throughput

0.541

High

659148

TPO5
Polyamine transporter TPO5

1

4

High-throughput

0.541

High

659152

MKAR
Very-long-chain 3-oxoacyl-CoA reductase

1

1

High-throughput

0.541

High

659174

SPC1
Signal peptidase complex subunit 1

1

2

High-throughput

0.541

High

659177

GPI8
GPI-anchor transamidase

1

1

High-throughput

0.541

High

659181

ERG25
C-4 methylsterol oxidase ERG25

1

1

High-throughput

0.541

High

659199

TECR
Very-long-chain enoyl-CoA reductase

1

1

High-throughput

0.541

High

659154

SSH1
Sec sixty-one protein homolog

1

0

High-throughput

0.518

High

659155

BSD2
Metal homeostatis protein BSD2

1

0

High-throughput

0.518

High

659160

FET3
Iron transport multicopper oxidase FET3

1

0

High-throughput

0.518

High

659165

ALG5
Dolichyl-phosphate beta-glucosyltransferase

1

0

High-throughput

0.518

High

659168

SNL1
HSP70 co-chaperone SNL1

1

0

High-throughput

0.518

High

659172

PHO86
Inorganic phosphate transporter PHO86

1

0

High-throughput

0.518

High

659173

GPI2
Phosphatidylinositol N-acetylglucosaminyltransferase GPI2 subunit

1

0

High-throughput

0.518

High

659191

GPI17
GPI transamidase component GPI17

1

0

High-throughput

0.518

High

510498

SSB1
Ribosome-associated molecular chaperone SSB1

2

1

High-throughput

0.504

High

659149

AVT3
Vacuolar amino acid transporter 3

1

1

High-throughput

0.494

High

659158

COS8
Protein COS8

1

1

High-throughput

0.494

High

659184

TNA1
High-affinity nicotinic acid transporter

1

2

High-throughput

0.494

High

659169

GST1
Glutathione S-transferase 1

1

0

High-throughput

0.486

High

541630

SEC63
Protein translocation protein SEC63

1

2

High-throughput

0.479

High

659135

PMT2
Dolichyl-phosphate-mannose--protein mannosyltransferase 2

1

5

High-throughput

0.479

High

659145

PMT1
Dolichyl-phosphate-mannose--protein mannosyltransferase 1

1

5

High-throughput

0.479

High

659175

PMT4
Dolichyl-phosphate-mannose--protein mannosyltransferase 4

1

5

High-throughput

0.479

High

659183

ORM1
Protein ORM1

1

2

Small-scale

0.479

High

659185

ALG9
Alpha-1,2-mannosyltransferase ALG9

1

1

High-throughput

0.479

High

659194

ORM2
Protein ORM2

1

2

Small-scale

0.479

High

659195

YET3
Endoplasmic reticulum transmembrane protein 3

1

5

High-throughput

0.479

High

659159

TEM1
Protein TEM1

1

1

High-throughput

0.464

High

635182

CWH43
Protein CWH43

1

0

High-throughput

0.458

High

412678

KAPA
cAMP-dependent protein kinase type 1

1

2

High-throughput

0.457

High

419822

SNF1
Carbon catabolite-derepressing protein kinase

1

2

High-throughput

0.457

High

520585

YPK1
Serine/threonine-protein kinase YPK1

1

4

Small-scale

0.457

High

636548

CDC48
Cell division control protein 48

1

1

High-throughput

0.445

High

543324

HSC82
ATP-dependent molecular chaperone HSC82

1

3

High-throughput

0.437

High

659187

TOM1
E3 ubiquitin-protein ligase TOM1

1

1

High-throughput

0.437

High

454218

TBA1
Tubulin alpha-1 chain

1

0

High-throughput

0.426

High

659192

SGPL
Sphingosine-1-phosphate lyase

1

0

High-throughput

0.426

High

365917

HSP82
ATP-dependent molecular chaperone HSP82

1

3

High-throughput

0.417

High

388949

SYTC
Threonine--tRNA ligase, cytoplasmic

1

1

High-throughput

0.407

High

493372

HSP72
Heat shock protein SSA2

1

1

High-throughput

0.407

High

502961

SEC7
Protein transport protein SEC7

1

2

High-throughput

0.407

High

555864

VATB
V-type proton ATPase subunit B

1

3

High-throughput

0.407

High

566538

VATA
V-type proton ATPase catalytic subunit A

1

4

High-throughput

0.407

High

659134

XPO1
Exportin-1

1

2

High-throughput

0.407

High

659138

HSP7F
Heat shock protein homolog SSE1

1

2

High-throughput

0.407

High

659141

PDR5
Pleiotropic ABC efflux transporter of multiple drugs

1

1

High-throughput

0.407

High

659142

CSE1
Importin alpha re-exporter

1

1

High-throughput

0.407

High

659157

YHI0
Putative proline--tRNA ligase YHR020W

1

1

High-throughput

0.407

High

659161

GEA2
ARF guanine-nucleotide exchange factor 2

1

2

High-throughput

0.407

High

659162

IMB4
Importin subunit beta-4

1

5

High-throughput

0.407

High

659163

SSB2
Ribosome-associated molecular chaperone SSB2

1

1

High-throughput

0.407

High

659170

BNI1
Protein BNI1

1

1

High-throughput

0.407

High

659180

MSN5
Protein MSN5

1

2

High-throughput

0.407

High

659193

IMB1
Importin subunit beta-1

1

5

High-throughput

0.407

High

659186

YD541
Putative uncharacterized oxidoreductase YDR541C

1

0

High-throughput

0.282

High

659189

GAS3
Probable 1,3-beta-glucanosyltransferase GAS3

1

0

High-throughput

0.282

High

659196

YP264
Probable transport protein YPL264C

1

0

High-throughput

0.282

High

659197

NDOR1
NADPH-dependent diflavin oxidoreductase 1

1

0

High-throughput

0.282

High

659176

PTK2
Serine/threonine-protein kinase PTK2/STK2

1

0

High-throughput

0.261

Low

659182

PDK2
[Pyruvate dehydrogenase

1

0

High-throughput

0.261

Low

557925

RPB3
DNA-directed RNA polymerase II subunit RPB3

1

0

Small-scale

0.249

Low

659133

TF2B
Transcription initiation factor IIB

1

0

High-throughput

0.249

Low

659150

NU170
Nucleoporin NUP170

1

0

High-throughput

0.249

Low

659178

TOM22
Mitochondrial import receptor subunit TOM22

1

0

High-throughput

0.249

Low

659153

ATG12
Ubiquitin-like protein ATG12

1

0

High-throughput

0.238

Low

659198

HSH49
Protein HSH49

1

0

High-throughput

0.238

Low

333713

ADH1
Alcohol dehydrogenase 1

1

0

High-throughput

0.232

Low

334631

G3P3
Glyceraldehyde-3-phosphate dehydrogenase 3

1

0

High-throughput

0.232

Low

360776

TBB
Tubulin beta chain

1

0

High-throughput

0.232

Low

367812

EF1A
Elongation factor 1-alpha

1

0

High-throughput

0.232

Low

399358

RLA0
Large ribosomal subunit protein uL10

1

0

High-throughput

0.232

Low

410934

PDC1
Pyruvate decarboxylase isozyme 1

1

0

High-throughput

0.232

Low

424381

PYR1
Multifunctional protein URA2

1

0

High-throughput

0.232

Low

479425

RS24A
Small ribosomal subunit protein eS24A

1

0

High-throughput

0.232

Low

498457

METK1
S-adenosylmethionine synthase 1

1

0

High-throughput

0.232

Low

540046

GFA1
Glutamine--fructose-6-phosphate aminotransferase [isomerizing]

1

0

High-throughput

0.232

Low

575921

ADT2
ADP,ATP carrier protein 2

1

0

High-throughput

0.232

Low

619537

MPCP
Mitochondrial phosphate carrier protein

1

0

High-throughput

0.232

Low

659136

EF2
Elongation factor 2

1

0

High-throughput

0.232

Low

659137

EIF3C
Eukaryotic translation initiation factor 3 subunit C

1

0

High-throughput

0.232

Low

659139

PTM1
Membrane protein PTM1

1

0

High-throughput

0.232

Low

659140

PRS7
26S proteasome regulatory subunit 7 homolog

1

0

High-throughput

0.232

Low

659143

BUD2
Inhibitory regulator protein BUD2/CLA2

1

0

High-throughput

0.232

Low

659146

GCN1
eIF-2-alpha kinase activator GCN1

1

0

High-throughput

0.232

Low

659166

LYS12
Homoisocitrate dehydrogenase, mitochondrial

1

0

High-throughput

0.232

Low

659167

MAM33
Mitochondrial acidic protein MAM33

1

0

High-throughput

0.232

Low

659171

MPG1
Mannose-1-phosphate guanyltransferase

1

0

High-throughput

0.232

Low

659179

RL4B
Large ribosomal subunit protein uL4B

1

0

High-throughput

0.232

Low

659190

DOP1
Protein dopey

1

0

High-throughput

0.232

Low


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Last updated: 15 Jul 2024