HitPredict

Interactor 1: SRSF6 (Q13247)
Serine/arginine-rich splicing factor 6 (Pre-mRNA-splicing factor SRP55) (Splicing factor, arginine/serine-rich 6)
Gene: SRSF6

Interactor 2: HERC5 (Q9UII4)
E3 ISG15--protein ligase HERC5 (EC 2.3.2.-) (Cyclin-E-binding protein 1) (HECT domain and RCC1-like domain-containing protein 5)
Gene: HERC5

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	0.60	0.536

Property	Details
Experiments	33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0003723 - RNA binding
Homologous interactions	19

Homologous interactions

Color coding for hit scores

	1 344 Hs			1 1024
+	Hs
		1314640 RBM4_HUMAN (1-343): 1.17e-47: 166: 17.05		HERC5_HUMAN (1-1024): 0: 1123: 100.00
+	Hs
		1308801 RBM4B_HUMAN (1-343): 2.62e-45: 160: 18.23		HERC5_HUMAN (1-1024): 0: 1123: 100.00
+	Hs
		992925 SRSF1_HUMAN (3-188): 3.02e-54: 180: 36.65		WWP1_HUMAN (588-1024): 8.35e-169: 520: 21.93
+	Hs
		125406 SRSF1_HUMAN (3-188): 3.02e-54: 180: 36.65		WWP2_HUMAN (599-1024): 1.14e-167: 516: 22.02
+	Hs
		1028813 SRSF5_HUMAN (2-180): 3.02e-46: 160: 64.25		WWP1_HUMAN (588-1024): 8.35e-169: 520: 21.93
+	Hs
		125425 SRSF5_HUMAN (2-180): 3.02e-46: 160: 64.25		WWP2_HUMAN (599-1024): 1.14e-167: 516: 22.02
+	Hs
		125426 SRSF6_HUMAN (1-323): 3.2e-43: 154: 100.00		WWP2_HUMAN (599-1024): 1.14e-167: 516: 22.02
+	Hs
		992947 SRSF1_HUMAN (3-188): 3.02e-54: 180: 36.65		SMUF1_HUMAN (593-1024): 1.71e-157: 485: 23.71
+	Sc
		633986 GBP2_YEAST (4-203): 4.8e-23: 100: 19.05		TOM1_YEAST (533-1024): 9.89e-156: 513: 26.70
+	Sc
		965475 NOP3_YEAST (3-326): 1.19e-19: 91.2: 19.94		TOM1_YEAST (533-1024): 9.89e-156: 513: 26.70
+	Hs
		125430 PABP4_HUMAN (101-191): 1.26e-12: 70.7: 21.88		WWP2_HUMAN (599-1024): 1.14e-167: 516: 22.02
+	Hs
		125752 RBM28_HUMAN (4-248): 1.53e-12: 70.6: 14.61		WWP2_HUMAN (599-1024): 1.14e-167: 516: 22.02
+	Hs
		125122 PABP1_HUMAN (101-191): 1.28e-11: 67.6: 19.79		WWP2_HUMAN (599-1024): 1.14e-167: 516: 22.02
+	Sc
		376913 PABP_YEAST (99-194): 1.33e-11: 67.6: 19.80		TOM1_YEAST (533-1024): 9.89e-156: 513: 26.70
+	Hs
		516643 PABP1_HUMAN (101-191): 1.28e-11: 67.6: 19.79		ITCH_HUMAN (593-1024): 1.76e-165: 511: 24.22
+	Hs
		952117 SRSF3_HUMAN (3-78): 2.4e-09: 57.4: 46.84		WWP1_HUMAN (588-1024): 8.35e-169: 520: 21.93
+	Sc
		765363 NOP3_YEAST (3-326): 1.19e-19: 91.2: 19.94		RSP5_YEAST (586-1024): 2.86e-156: 484: 23.88
+	Hs
		125374 SRSF3_HUMAN (3-78): 2.4e-09: 57.4: 46.84		WWP2_HUMAN (599-1024): 1.14e-167: 516: 22.02
+	Hs
		1347037 RBM28_HUMAN (4-248): 1.53e-12: 70.6: 14.61		HECW2_HUMAN (534-1024): 2.54e-153: 496: 23.43