Protein: E2F3
Transcription factor E2F3 (E2F-3)

Gene: E2F3
Organism: Homo sapiens
Interactions: 134
UniProt ID: O00716

Gene Ontology (top 5):
GO:0000082 - G1/S transition of mitotic cell cycle
GO:0000785 - chromatin
GO:0000978 - RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0000981 - DNA-binding transcription factor activity, RNA polymerase II-specific
GO:0000987 - cis-regulatory region sequence-specific DNA binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

143382

RB
Retinoblastoma-associated protein

9

20

Small-scale

0.968

High

143432

TFDP1
Transcription factor Dp-1

4

20

Small-scale

0.890

High

143433

TFDP2
Transcription factor Dp-2

3

20

High-throughput

0.861

High

143446

TFDP3
Transcription factor Dp family member 3

3

20

High-throughput

0.861

High

143398

RBL1
Retinoblastoma-like protein 1

2

20

Small-scale

0.754

High

143425

E2F1
Transcription factor E2F1

2

14

High-throughput

0.754

High

143406

CCNF
Cyclin-F

2

16

Small-scale

0.620

High

143374

E2F6
Transcription factor E2F6

1

14

High-throughput

0.618

High

143436

E2F2
Transcription factor E2F2

1

14

High-throughput

0.618

High

143441

E2F5
Transcription factor E2F5

1

14

High-throughput

0.618

High

143444

E2F4
Transcription factor E2F4

1

14

High-throughput

0.618

High

143387

MYBB
Myb-related protein B

2

6

Small-scale

0.586

High

143460

CBP
CREB-binding protein

2

13

Small-scale

0.586

High

143392

TFE3
Transcription factor E3

1

3

Small-scale

0.573

High

143385

PARP1
Poly [ADP-ribose] polymerase 1

2

5

Small-scale

0.571

High

143478

HELLS
Lymphoid-specific helicase

1

9

Small-scale

0.569

High

143450

ATAD2
ATPase family AAA domain-containing protein 2

1

3

Small-scale

0.561

High

143489

FZR1
Fizzy-related protein homolog

1

4

Small-scale

0.561

High

143414

HCFC1
Host cell factor 1

1

3

Small-scale

0.552

High

143457

RYBP
RING1 and YY1-binding protein

1

4

Small-scale

0.552

High

143407

BCL6
B-cell lymphoma 6 protein

1

1

Small-scale

0.536

High

143417

RCAN1
Calcipressin-1

1

0

High-throughput

0.518

High

143487

DNM3L
DNA

1

4

Small-scale

0.501

High

143496

UCHL5
Ubiquitin carboxyl-terminal hydrolase isozyme L5

1

3

Small-scale

0.501

High

143412

R144A
E3 ubiquitin-protein ligase RNF144A

1

3

Small-scale

0.481

High

143426

SPIB
Transcription factor Spi-B

1

8

Small-scale

0.481

High

143435

FHL2
Four and a half LIM domains protein 2

1

5

Small-scale

0.481

High

143453

MGAP
MAX gene-associated protein

1

4

Small-scale

0.481

High

143464

TEAD3
Transcriptional enhancer factor TEF-5

1

2

Small-scale

0.481

High

143470

IPKB
cAMP-dependent protein kinase inhibitor beta

1

1

Small-scale

0.481

High

143473

WNK1
Serine/threonine-protein kinase WNK1

1

3

Small-scale

0.481

High

143476

SRA1
Steroid receptor RNA activator 1

1

0

Small-scale

0.480

High

142706

NFIB
Nuclear factor 1 B-type

1

15

High-throughput

0.479

High

143366

KMT2D
Histone-lysine N-methyltransferase 2D

1

12

Small-scale

0.479

High

143375

MYC
Myc proto-oncogene protein

1

11

High-throughput

0.479

High

143379

P53
Cellular tumor antigen p53

1

3

High-throughput

0.479

High

143384

NFIC
Nuclear factor 1 C-type

1

17

High-throughput

0.479

High

143389

CCNB1
G2/mitotic-specific cyclin-B1

1

9

Small-scale

0.479

High

143393

USF1
Upstream stimulatory factor 1

1

7

Small-scale

0.479

High

143395

TNR6
Tumor necrosis factor receptor superfamily member 6

1

1

High-throughput

0.479

High

143399

PML
Protein PML

1

8

Small-scale

0.479

High

143400

MCM4
DNA replication licensing factor MCM4

1

3

Small-scale

0.479

High

143422

H31
Histone H3.1

1

3

High-throughput

0.479

High

143423

H33
Histone H3.3

1

3

High-throughput

0.479

High

143429

NFIA
Nuclear factor 1 A-type

1

16

High-throughput

0.479

High

143430

TIF1B
Transcription intermediary factor 1-beta

1

8

Small-scale

0.479

High

143431

HDAC1
Histone deacetylase 1

1

6

Small-scale

0.479

High

143438

NFIX
Nuclear factor 1 X-type

1

17

High-throughput

0.479

High

143452

MIB1
E3 ubiquitin-protein ligase MIB1

1

4

High-throughput

0.479

High

143462

LMBL2
Lethal(3)malignant brain tumor-like protein 2

1

10

Small-scale

0.479

High

143463

LMBL3
Lethal(3)malignant brain tumor-like protein 3

1

13

Small-scale

0.479

High

143469

PCGF6
Polycomb group RING finger protein 6

1

15

High-throughput

0.479

High

143471

BRD8
Bromodomain-containing protein 8

1

16

Small-scale

0.479

High

143492

PA2G4
Proliferation-associated protein 2G4

1

3

Small-scale

0.479

High

143388

PCNA
Proliferating cell nuclear antigen

1

0

Small-scale

0.458

High

143442

VPS72
Vacuolar protein sorting-associated protein 72 homolog

1

0

Small-scale

0.458

High

143467

DDA1
DET1- and DDB1-associated protein 1

1

0

High-throughput

0.458

High

123498

MYO1C
Unconventional myosin-Ic

1

2

Small-scale

0.445

High

143367

TCRG1
Transcription elongation regulator 1

1

3

Small-scale

0.445

High

143370

AKAP8
A-kinase anchor protein 8

1

2

Small-scale

0.445

High

143371

KDM1A
Lysine-specific histone demethylase 1A

1

6

Small-scale

0.445

High

143372

ZBED4
Zinc finger BED domain-containing protein 4

1

1

Small-scale

0.445

High

143373

ZC11A
Zinc finger CCCH domain-containing protein 11A

1

1

Small-scale

0.445

High

143390

ACADS
Short-chain specific acyl-CoA dehydrogenase, mitochondrial

1

2

Small-scale

0.445

High

143394

RS3
Small ribosomal subunit protein uS3

1

1

Small-scale

0.445

High

143397

SMCA1
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 1

1

5

Small-scale

0.445

High

143401

CTNA1
Catenin alpha-1

1

1

Small-scale

0.445

High

143402

K1C9
Keratin, type I cytoskeletal 9

1

1

Small-scale

0.445

High

143403

TRI23
E3 ubiquitin-protein ligase TRIM23

1

1

Small-scale

0.445

High

143408

MATR3
Matrin-3

1

3

Small-scale

0.445

High

143409

MSH2
DNA mismatch repair protein Msh2

1

1

Small-scale

0.445

High

143413

RAB13
Ras-related protein Rab-13

1

1

Small-scale

0.445

High

143415

MSH6
DNA mismatch repair protein Msh6

1

1

Small-scale

0.445

High

143416

NUP98
Nuclear pore complex protein Nup98-Nup96

1

1

Small-scale

0.445

High

143424

HNRPU
Heterogeneous nuclear ribonucleoprotein U

1

2

Small-scale

0.445

High

143427

CEBPZ
CCAAT/enhancer-binding protein zeta

1

1

Small-scale

0.445

High

143428

DHX9
ATP-dependent RNA helicase A

1

2

Small-scale

0.445

High

143434

WRN
Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN

1

3

Small-scale

0.445

High

143437

LBR
Delta(14)-sterol reductase LBR

1

1

Small-scale

0.445

High

143439

NOLC1
Nucleolar and coiled-body phosphoprotein 1

1

2

Small-scale

0.445

High

143440

U5S1
116 kDa U5 small nuclear ribonucleoprotein component

1

1

Small-scale

0.445

High

143445

DDB1
DNA damage-binding protein 1

1

3

Small-scale

0.445

High

143474

DHX33
ATP-dependent RNA helicase DHX33

1

1

Small-scale

0.445

High

143477

TF7L2
Transcription factor 7-like 2

1

7

Small-scale

0.445

High

143483

DIC
Mitochondrial dicarboxylate carrier

1

2

Small-scale

0.445

High

143485

SMBT1
Scm-like with four MBT domains protein 1

1

13

Small-scale

0.445

High

143486

DDX41
Probable ATP-dependent RNA helicase DDX41

1

1

Small-scale

0.445

High

143490

NOTC3
Neurogenic locus notch homolog protein 3

1

1

Small-scale

0.445

High

143383

CFAH
Complement factor H

1

1

Small-scale

0.437

High

143376

K1C14
Keratin, type I cytoskeletal 14

1

0

Small-scale

0.426

High

143377

LMNA
Prelamin-A/C [Cleaved into: Lamin-A/C

1

0

Small-scale

0.426

High

143378

K2C1
Keratin, type II cytoskeletal 1

1

0

Small-scale

0.426

High

143381

ITB1
Integrin beta-1

1

0

Small-scale

0.426

High

143391

HSP76
Heat shock 70 kDa protein 6

1

0

Small-scale

0.426

High

143418

DPOG1
DNA polymerase subunit gamma-1

1

0

Small-scale

0.426

High

143421

RL40
Ubiquitin-ribosomal protein eL40 fusion protein

1

0

Small-scale

0.426

High

143443

ENOX2
Ecto-NOX disulfide-thiol exchanger 2

1

0

Small-scale

0.426

High

143447

INT3
Integrator complex subunit 3

1

0

Small-scale

0.426

High

143449

INT5
Integrator complex subunit 5

1

0

Small-scale

0.426

High

143451

RS27L
Ribosomal protein eS27-like

1

0

Small-scale

0.426

High

143458

DOCK8
Dedicator of cytokinesis protein 8

1

0

Small-scale

0.426

High

143459

NPL4
Nuclear protein localization protein 4 homolog

1

0

Small-scale

0.426

High

143461

PMM1
Phosphomannomutase 1

1

0

Small-scale

0.426

High

143465

CND3
Condensin complex subunit 3

1

0

Small-scale

0.426

High

143472

RBNS5
Rabenosyn-5

1

0

Small-scale

0.426

High

143481

TECR
Very-long-chain enoyl-CoA reductase

1

0

Small-scale

0.426

High

143488

INT6
Integrator complex subunit 6

1

0

Small-scale

0.426

High

143493

ZN148
Zinc finger protein 148

1

0

Small-scale

0.426

High

143369

MYO1B
Unconventional myosin-Ib

1

2

Small-scale

0.407

High

143380

AT1A1
Sodium/potassium-transporting ATPase subunit alpha-1

1

1

Small-scale

0.407

High

143404

HSPA9
Stress-70 protein, mitochondrial

1

1

Small-scale

0.407

High

143410

GPDM
Glycerol-3-phosphate dehydrogenase, mitochondrial

1

1

Small-scale

0.407

High

143454

MIRO2
Mitochondrial Rho GTPase 2

1

3

Small-scale

0.407

High

143455

MIRO1
Mitochondrial Rho GTPase 1

1

3

Small-scale

0.407

High

143468

GTPB2
GTP-binding protein 2

1

2

Small-scale

0.407

High

143480

ATD3A
ATPase family AAA domain-containing protein 3A

1

2

Small-scale

0.407

High

143482

DHCR7
7-dehydrocholesterol reductase

1

1

Small-scale

0.407

High

143495

AFG32
Mitochondrial inner membrane m-AAA protease component AFG3L2

1

1

Small-scale

0.407

High

143491

SSRG
Translocon-associated protein subunit gamma

1

0

High-throughput

0.269

Low

143368

MOT4
Monocarboxylate transporter 4

1

0

Small-scale

0.232

Low

143386

PPBI
Intestinal-type alkaline phosphatase

1

0

Small-scale

0.232

Low

143396

NDUS1
NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial

1

0

Small-scale

0.232

Low

143405

ECHA
Trifunctional enzyme subunit alpha, mitochondrial

1

0

Small-scale

0.232

Low

143411

STT3A
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3A

1

0

Small-scale

0.232

Low

143419

TMM33
Transmembrane protein 33

1

0

Small-scale

0.232

Low

143420

S61A1
Protein transport protein Sec61 subunit alpha isoform 1

1

0

Small-scale

0.232

Low

143448

S27A4
Long-chain fatty acid transport protein 4

1

0

Small-scale

0.232

Low

143456

AGRF5
Adhesion G protein-coupled receptor F5

1

0

Small-scale

0.232

Low

143466

RT63
Large ribosomal subunit protein mL63

1

0

Small-scale

0.232

Low

143475

GPAT1
Glycerol-3-phosphate acyltransferase 1, mitochondrial

1

0

Small-scale

0.232

Low

143479

PLCE
1-acyl-sn-glycerol-3-phosphate acyltransferase epsilon

1

0

Small-scale

0.232

Low

143484

SUN2
SUN domain-containing protein 2

1

0

Small-scale

0.232

Low

143494

CCDC9
Coiled-coil domain-containing protein 9

1

0

Small-scale

0.232

Low

143497

PCLO
Protein piccolo

1

0

Small-scale

0.232

Low


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Last updated: 11Aug2025