HitPredict

Interactor 1: MD2L1 (Q13257)
Mitotic spindle assembly checkpoint protein MAD2A (HsMAD2) (Mitotic arrest deficient 2-like protein 1) (MAD2-like protein 1)
Gene: MAD2L1

Interactor 2: MD2L2 (Q9UI95)
Mitotic spindle assembly checkpoint protein MAD2B (Mitotic arrest deficient 2-like protein 2) (MAD2-like protein 2) (REV7 homolog) (hREV7)
Gene: MAD2L2

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.72	1.00	0.854

The method score is based on:

Property	Details
Experiments	30111544, 29656893, 10660610
Identification Methods	two hybrid, affinity chromatography technology, pull down, anti tag coimmunoprecipitation
Interaction Type	direct interaction, physical association, association

The annotation score is based on:

Property	Details
Interacting Pfam domains	HORMA~HORMA
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005737 - cytoplasm GO:0007094 - mitotic spindle assembly checkpoint signaling GO:0042177 - negative regulation of protein catabolic process and 2 others more... GO:0051301 - cell division GO:1904667 - negative regulation of ubiquitin protein ligase activity
Homologous interactions	5

Homologous interactions

Color coding for hit scores

	1	205
Hs

1	211

Service provided by Combinatics, Japan

Last updated: 15 Jul 2024