HitPredict

Interactor 1: PTK7 (Q13308)
Inactive tyrosine-protein kinase 7 (Colon carcinoma kinase 4) (CCK-4) (Protein-tyrosine kinase 7) (Pseudo tyrosine kinase receptor 7) (Tyrosine-protein kinase-like 7)
Gene: PTK7

Interactor 2: PKHA4 (Q9H4M7)
Pleckstrin homology domain-containing family A member 4 (PH domain-containing family A member 4) (Phosphoinositol 3-phosphate-binding protein 1) (PEPP-1)
Gene: PLEKHA4

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	31091453
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	PH~PK_Tyr_Ser-Thr
Common GO terms	GO:0005886 - plasma membrane GO:0090263 - positive regulation of canonical Wnt signaling pathway
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1070 Hs			1 779
+	Hs
		1153281 CNTN4_HUMAN (2-708): 1.66e-64: 239: 12.87		PKHA7_HUMAN (2-440): 4.98e-50: 192: 28.02
+	Hs
		384791 NTRK1_HUMAN (555-1061): 3.09e-57: 214: 30.31		GAB1_HUMAN (52-611): 6.48e-53: 197: 13.92
+	Hs
		1035415 ALK_HUMAN (695-1067): 1.21e-52: 204: 32.90		GAB1_HUMAN (52-611): 6.48e-53: 197: 13.92
+	Hs
		384251 NTRK1_HUMAN (555-1061): 3.09e-57: 214: 30.31		RASA1_HUMAN (72-437): 2.74e-44: 174: 11.32
+	Dm
		1180582 Q7KJ08_DROME (793-1068): 3.88e-56: 215: 39.36		Q7KNQ9_DROME (5-282): 1.28e-40: 163: 19.74
+	Hs
		385750 NTRK1_HUMAN (555-1061): 3.09e-57: 214: 30.31		PKHA6_HUMAN (3-364): 2.39e-40: 162: 26.02
+	Hs
		385546 NTRK1_HUMAN (555-1061): 3.09e-57: 214: 30.31		PKHA1_HUMAN (16-261): 3.76e-39: 151: 16.92
+	Hs
		1335084 ALK_HUMAN (695-1067): 1.21e-52: 204: 32.90		PKHA1_HUMAN (16-261): 3.76e-39: 151: 16.92
+	Hs
		601535 FGFR2_HUMAN (297-603): 8.71e-43: 170: 18.52		MPRIP_HUMAN (2-499): 4.76e-44: 173: 16.57
+	Hs
		507983 FGFR1_HUMAN (2-231): 7.15e-34: 142: 12.41		GAB1_HUMAN (52-611): 6.48e-53: 197: 13.92
+	Hs
		508062 FGFR1_HUMAN (2-231): 7.15e-34: 142: 12.41		PKHA7_HUMAN (2-440): 4.98e-50: 192: 28.02
+	Hs
		385781 NTRK1_HUMAN (555-1061): 3.09e-57: 214: 30.31		FARP1_HUMAN (6-167): 1.07e-24: 112: 17.96
+	Hs
		674415 UFO_HUMAN (21-348): 3.55e-29: 127: 18.80		GAB1_HUMAN (52-611): 6.48e-53: 197: 13.92
+	Hs
		507850 FGFR1_HUMAN (2-231): 7.15e-34: 142: 12.41		RASA1_HUMAN (72-437): 2.74e-44: 174: 11.32
+	Hs
		508205 FGFR1_HUMAN (2-231): 7.15e-34: 142: 12.41		PKHA1_HUMAN (16-261): 3.76e-39: 151: 16.92
+	Hs
		508203 FGFR1_HUMAN (2-231): 7.15e-34: 142: 12.41		PKHA5_HUMAN (2-653): 1.62e-36: 150: 17.61
+	Hs
		299238 FGFR3_HUMAN (101-408): 1.28e-38: 157: 20.06		FARP2_HUMAN (5-183): 2.45e-30: 130: 21.69
+	Hs
		601589 FGFR2_HUMAN (297-603): 8.71e-43: 170: 18.52		TARA_HUMAN (49-471): 7.83e-20: 97.3: 15.21
+	Hs
		508287 FGFR1_HUMAN (2-231): 7.15e-34: 142: 12.41		FARP1_HUMAN (6-167): 1.07e-24: 112: 17.96
+	Hs
		508190 FGFR1_HUMAN (2-231): 7.15e-34: 142: 12.41		TARA_HUMAN (49-471): 7.83e-20: 97.3: 15.21