Protein: OTUD4
OTU domain-containing protein 4 (EC 3.4.19.12) (HIV-1-induced protein HIN-1)

Gene: OTUD4
Organism: Homo sapiens
Interactions: 235
UniProt ID: Q01804

Gene Ontology (top 5):
GO:0003723 - RNA binding
GO:0004843 - cysteine-type deubiquitinase activity
GO:0005634 - nucleus
GO:0005737 - cytoplasm
GO:0005829 - cytosol

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

475641

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

5

12

Small-scale

0.919

High

966618

EXOS8
Exosome complex component RRP43

3

1

High-throughput

0.675

High

966530

TRAF1
TNF receptor-associated factor 1

3

3

Small-scale

0.667

High

966633

MYCBP
c-Myc-binding protein

3

1

High-throughput

0.662

High

966568

RC3H1
Roquin-1

3

3

High-throughput

0.640

High

966570

WBP2L
Postacrosomal sheath WW domain-binding protein

3

0

High-throughput

0.638

High

369428

ESR1
Estrogen receptor

3

3

High-throughput

0.633

High

966566

OTUD3
OTU domain-containing protein 3

1

7

Small-scale

0.618

High

966654

ALG13
UDP-N-acetylglucosamine transferase subunit ALG13

1

6

High-throughput

0.618

High

966664

ZRAN1
Ubiquitin thioesterase ZRANB1

1

6

High-throughput

0.618

High

966647

AGO3
Protein argonaute-3

2

1

High-throughput

0.611

High

509937

VDR
Vitamin D3 receptor

2

4

High-throughput

0.606

High

966594

ZN655
Zinc finger protein 655

2

1

High-throughput

0.606

High

949007

HTRA4
Serine protease HTRA4

2

0

High-throughput

0.602

High

966643

IQCN
IQ domain-containing protein N

2

0

High-throughput

0.602

High

844013

FXR2
RNA-binding protein FXR2

2

8

High-throughput

0.601

High

966631

UBL7
Ubiquitin-like protein 7

1

0

Small-scale

0.586

High

966669

LHX6
LIM/homeobox protein Lhx6

2

0

High-throughput

0.585

High

603457

FBRL
rRNA 2'-O-methyltransferase fibrillarin

2

2

High-throughput

0.584

High

966533

G3BP1
Ras GTPase-activating protein-binding protein 1

2

5

Small-scale

0.584

High

966650

RC3H2
Roquin-2

2

6

High-throughput

0.584

High

235074

DOK2
Docking protein 2

2

2

High-throughput

0.571

High

966537

RIN1
Ras and Rab interactor 1

2

1

High-throughput

0.571

High

966582

MAVS
Mitochondrial antiviral-signaling protein

1

3

Small-scale

0.561

High

966616

UBP7
Ubiquitin carboxyl-terminal hydrolase 7

1

2

Small-scale

0.561

High

966629

ALKB3
Alpha-ketoglutarate-dependent dioxygenase alkB homolog 3

1

1

Small-scale

0.561

High

551115

ITF2
Transcription factor 4

1

0

High-throughput

0.549

High

786315

STAT1
Signal transducer and activator of transcription 1-alpha/beta

1

0

High-throughput

0.549

High

966525

REL
Proto-oncogene c-Rel

1

0

High-throughput

0.549

High

657827

ELK4
ETS domain-containing protein Elk-4

2

0

High-throughput

0.547

High

966532

MK07
Mitogen-activated protein kinase 7

2

0

High-throughput

0.547

High

197004

PRP4
U4/U6 small nuclear ribonucleoprotein Prp4

1

2

High-throughput

0.536

High

323696

BAG2
BAG family molecular chaperone regulator 2

1

2

High-throughput

0.536

High

577911

RL17
Large ribosomal subunit protein uL22

1

2

High-throughput

0.536

High

851457

NEK4
Serine/threonine-protein kinase Nek4

1

4

High-throughput

0.536

High

966531

DAZ2
Deleted in azoospermia protein 2

1

5

High-throughput

0.536

High

966574

TPTE2
Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase TPTE2

1

3

High-throughput

0.536

High

966576

ZBT49
Zinc finger and BTB domain-containing protein 49

1

1

High-throughput

0.536

High

966595

TSYL6
Testis-specific Y-encoded-like protein 6

1

1

High-throughput

0.536

High

966601

DDX55
ATP-dependent RNA helicase DDX55

1

4

High-throughput

0.536

High

966624

NAF1
H/ACA ribonucleoprotein complex non-core subunit NAF1

1

1

High-throughput

0.536

High

966637

PCGF1
Polycomb group RING finger protein 1

1

7

Small-scale

0.536

High

966653

E41L5
Band 4.1-like protein 5

1

1

High-throughput

0.536

High

966673

CLC11
C-type lectin domain family 11 member A

1

1

High-throughput

0.536

High

966681

DUS10
Dual specificity protein phosphatase 10

1

1

High-throughput

0.536

High

280791

KRT36
Keratin, type I cuticular Ha6

1

4

High-throughput

0.515

High

402820

TETN
Tetranectin

1

1

High-throughput

0.515

High

409050

K2C8
Keratin, type II cytoskeletal 8

1

3

High-throughput

0.515

High

636310

DNJB1
DnaJ homolog subfamily B member 1

1

1

High-throughput

0.515

High

943665

KRT85
Keratin, type II cuticular Hb5

1

3

High-throughput

0.515

High

966540

FLNC
Filamin-C

1

6

High-throughput

0.515

High

966542

KT33B
Keratin, type I cuticular Ha3-II

1

4

High-throughput

0.515

High

966548

K1H1
Keratin, type I cuticular Ha1

1

4

High-throughput

0.515

High

966578

TBA1A
Tubulin alpha-1A chain

1

1

High-throughput

0.515

High

966648

BRF2
Transcription factor IIIB 50 kDa subunit

1

1

High-throughput

0.515

High

966667

BAG5
BAG family molecular chaperone regulator 5

1

1

High-throughput

0.515

High

966522

HSF2
Heat shock factor protein 2

1

0

High-throughput

0.513

High

966538

NOG2
Nucleolar GTP-binding protein 2

1

0

High-throughput

0.513

High

966557

KRA61
Keratin-associated protein 6-1

1

0

High-throughput

0.513

High

966559

KR197
Keratin-associated protein 19-7

1

0

High-throughput

0.513

High

966561

CRY2
Cryptochrome-2

1

0

High-throughput

0.513

High

966563

LBH
Protein LBH

1

0

High-throughput

0.513

High

966606

CKAP2
Cytoskeleton-associated protein 2

1

0

High-throughput

0.513

High

966661

GAR1
H/ACA ribonucleoprotein complex subunit 1

1

0

High-throughput

0.513

High

966676

FAN1
Fanconi-associated nuclease 1

1

0

High-throughput

0.513

High

966679

SPCS1
Signal peptidase complex subunit 1

1

0

High-throughput

0.513

High

296712

ATG12
Ubiquitin-like protein ATG12

1

0

High-throughput

0.493

High

378516

OAT
Ornithine aminotransferase, mitochondrial

1

0

High-throughput

0.493

High

413087

AGAL
Alpha-galactosidase A

1

0

High-throughput

0.493

High

847184

GALK1
Galactokinase

1

0

High-throughput

0.493

High

878512

PSA
Puromycin-sensitive aminopeptidase

1

0

High-throughput

0.493

High

966521

DSG1
Desmoglein-1

1

0

High-throughput

0.493

High

966526

MTG8
Protein CBFA2T1

1

0

High-throughput

0.493

High

966535

ILK
Integrin-linked protein kinase

1

0

High-throughput

0.493

High

966619

NMD3
60S ribosomal export protein NMD3

1

0

High-throughput

0.493

High

966656

GEPH
Gephyrin [Includes: Molybdopterin adenylyltransferase

1

0

High-throughput

0.493

High

952924

PRR5
Proline-rich protein 5

1

0

Small-scale

0.479

High

47767

RBM47
RNA-binding protein 47

1

7

High-throughput

0.479

High

118858

GTPB1
GTP-binding protein 1

1

1

High-throughput

0.479

High

128142

IF2B3
Insulin-like growth factor 2 mRNA-binding protein 3

1

13

Small-scale

0.479

High

133983

DDX3X
ATP-dependent RNA helicase DDX3X

1

2

High-throughput

0.479

High

162643

XPO1
Exportin-1

1

5

High-throughput

0.479

High

198873

RFOX2
RNA binding protein fox-1 homolog 2

1

9

High-throughput

0.479

High

235807

HNRPQ
Heterogeneous nuclear ribonucleoprotein Q

1

7

High-throughput

0.479

High

242078

PAGE4
P antigen family member 4

1

1

High-throughput

0.479

High

268975

CSDE1
Cold shock domain-containing protein E1

1

2

High-throughput

0.479

High

322492

STAU1
Double-stranded RNA-binding protein Staufen homolog 1

1

2

High-throughput

0.479

High

325694

LATS1
Serine/threonine-protein kinase LATS1

1

5

High-throughput

0.479

High

326594

SNAI1
Zinc finger protein SNAI1

1

3

Small-scale

0.479

High

374073

RAF1
RAF proto-oncogene serine/threonine-protein kinase

1

1

High-throughput

0.479

High

377258

GCR
Glucocorticoid receptor

1

3

High-throughput

0.479

High

455333

PARP1
Poly [ADP-ribose] polymerase 1

1

6

High-throughput

0.479

High

485117

GLI3
Transcriptional activator GLI3

1

1

High-throughput

0.479

High

501988

BIP
Endoplasmic reticulum chaperone BiP

1

2

High-throughput

0.479

High

516473

PABP1
Polyadenylate-binding protein 1

1

6

High-throughput

0.479

High

644241

TTP
mRNA decay activator protein ZFP36

1

4

High-throughput

0.479

High

668342

RBMS1
RNA-binding motif, single-stranded-interacting protein 1

1

7

High-throughput

0.479

High

680440

TIA1
Cytotoxic granule associated RNA binding protein TIA1

1

5

High-throughput

0.479

High

714516

GRK5
G protein-coupled receptor kinase 5

1

4

High-throughput

0.479

High

779263

CCNF
Cyclin-F

1

1

High-throughput

0.479

High

815232

TISD
mRNA decay activator protein ZFP36L2

1

4

High-throughput

0.479

High

820891

PRC2A
Protein PRRC2A

1

10

High-throughput

0.479

High

839933

F10A1
Hsc70-interacting protein

1

3

High-throughput

0.479

High

843613

FXR1
RNA-binding protein FXR1

1

8

High-throughput

0.479

High

892997

RS20
Small ribosomal subunit protein uS10

1

1

High-throughput

0.479

High

908396

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

1

High-throughput

0.479

High

926937

1433Z
14-3-3 protein zeta/delta

1

2

High-throughput

0.479

High

934671

H31
Histone H3.1

1

2

High-throughput

0.479

High

963505

TIAR
Nucleolysin TIAR

1

5

Small-scale

0.479

High

966523

TLE2
Transducin-like enhancer protein 2

1

5

High-throughput

0.479

High

966524

TLE3
Transducin-like enhancer protein 3

1

5

High-throughput

0.479

High

966527

FMR1
Fragile X messenger ribonucleoprotein 1

1

8

High-throughput

0.479

High

966528

ELAV2
ELAV-like protein 2

1

7

Small-scale

0.479

High

966529

FLII
Protein flightless-1 homolog

1

2

Small-scale

0.479

High

966536

TBB3
Tubulin beta-3 chain

1

2

High-throughput

0.479

High

966539

UBP2L
Ubiquitin-associated protein 2-like

1

3

High-throughput

0.479

High

966541

CAPR1
Caprin-1

1

1

High-throughput

0.479

High

966543

PUM1
Pumilio homolog 1

1

3

High-throughput

0.479

High

966544

SMC1A
Structural maintenance of chromosomes protein 1A

1

2

High-throughput

0.479

High

966545

UBP10
Ubiquitin carboxyl-terminal hydrolase 10

1

3

Small-scale

0.479

High

966547

R3HD1
R3H domain-containing protein 1

1

5

High-throughput

0.479

High

966549

PCBP1
Poly(rC)-binding protein 1

1

8

High-throughput

0.479

High

966555

CPEB4
Cytoplasmic polyadenylation element-binding protein 4

1

5

High-throughput

0.479

High

966564

PRC2B
Protein PRRC2B

1

9

High-throughput

0.479

High

966571

ALKB2
DNA oxidative demethylase ALKBH2

1

1

Small-scale

0.479

High

966572

CEP85
Centrosomal protein of 85 kDa

1

1

High-throughput

0.479

High

966573

RPTN
Repetin

1

1

High-throughput

0.479

High

966575

MEX3B
RNA-binding protein MEX3B

1

1

High-throughput

0.479

High

966577

TRI67
Tripartite motif-containing protein 67

1

11

High-throughput

0.479

High

966579

ZCCHV
Zinc finger CCCH-type antiviral protein 1

1

6

High-throughput

0.479

High

966580

PARPT
Protein mono-ADP-ribosyltransferase TIPARP

1

3

High-throughput

0.479

High

966585

YTHD3
YTH domain-containing family protein 3

1

6

High-throughput

0.479

High

966586

PATL1
Protein PAT1 homolog 1

1

2

High-throughput

0.479

High

966587

ZN598
E3 ubiquitin-protein ligase ZNF598

1

1

High-throughput

0.479

High

966589

HORN
Hornerin

1

1

High-throughput

0.479

High

966590

NUDC3
NudC domain-containing protein 3

1

1

High-throughput

0.479

High

966591

Z3H7A
Zinc finger CCCH domain-containing protein 7A

1

2

High-throughput

0.479

High

966592

XRN1
5'-3' exoribonuclease 1

1

1

High-throughput

0.479

High

966597

SERB1
SERPINE1 mRNA-binding protein 1

1

2

High-throughput

0.479

High

966599

LS14A
Protein LSM14 homolog A

1

1

High-throughput

0.479

High

966600

TNR6A
Trinucleotide repeat-containing gene 6A protein

1

6

High-throughput

0.479

High

966602

PUM2
Pumilio homolog 2

1

3

High-throughput

0.479

High

966604

SMAP2
Stromal membrane-associated protein 2

1

1

High-throughput

0.479

High

966607

SMG7
Nonsense-mediated mRNA decay factor SMG7

1

2

High-throughput

0.479

High

966608

BAP1
Ubiquitin carboxyl-terminal hydrolase BAP1

1

1

High-throughput

0.479

High

966609

CNOT9
CCR4-NOT transcription complex subunit 9

1

1

High-throughput

0.479

High

966610

LAR4B
La-related protein 4B

1

1

High-throughput

0.479

High

966611

ESR2
Estrogen receptor beta

1

3

High-throughput

0.479

High

966612

CELF1
CUGBP Elav-like family member 1

1

6

High-throughput

0.479

High

966613

RENT1
Regulator of nonsense transcripts 1

1

3

High-throughput

0.479

High

966614

DAZL
Deleted in azoospermia-like

1

10

High-throughput

0.479

High

966615

USP9X
Ubiquitin carboxyl-terminal hydrolase 9X

1

1

Small-scale

0.479

High

966617

FBXW7
F-box/WD repeat-containing protein 7

1

1

High-throughput

0.479

High

966620

SPDLY
Protein Spindly

1

1

High-throughput

0.479

High

966621

RNF31
E3 ubiquitin-protein ligase RNF31

1

5

High-throughput

0.479

High

966625

FUBP3
Far upstream element-binding protein 3

1

10

High-throughput

0.479

High

966630

CIC
Protein capicua homolog

1

4

High-throughput

0.479

High

966634

ATX2
Ataxin-2

1

2

High-throughput

0.479

High

966635

ANM1
Protein arginine N-methyltransferase 1

1

2

High-throughput

0.479

High

966636

TRI56
E3 ubiquitin-protein ligase TRIM56

1

6

High-throughput

0.479

High

966638

YTHD1
YTH domain-containing family protein 1

1

6

High-throughput

0.479

High

966639

CPEB1
Cytoplasmic polyadenylation element-binding protein 1

1

3

High-throughput

0.479

High

966640

UNK
RING finger protein unkempt homolog

1

6

High-throughput

0.479

High

966642

MKRN2
E3 ubiquitin-protein ligase makorin-2

1

2

High-throughput

0.479

High

966645

EGLN3
Prolyl hydroxylase EGLN3

1

2

High-throughput

0.479

High

966646

TDRD3
Tudor domain-containing protein 3

1

1

High-throughput

0.479

High

966649

CYBP
Calcyclin-binding protein

1

1

High-throughput

0.479

High

966652

MOV10
Helicase MOV-10

1

3

High-throughput

0.479

High

966657

PAR11
Protein mono-ADP-ribosyltransferase PARP11

1

3

High-throughput

0.479

High

966658

4ET
Eukaryotic translation initiation factor 4E transporter

1

1

High-throughput

0.479

High

966659

F120C
Constitutive coactivator of PPAR-gamma-like protein 2

1

2

High-throughput

0.479

High

966663

IF2B1
Insulin-like growth factor 2 mRNA-binding protein 1

1

10

High-throughput

0.479

High

966665

SEC63
Translocation protein SEC63 homolog

1

1

High-throughput

0.479

High

966666

AGO2
Protein argonaute-2

1

1

High-throughput

0.479

High

966668

G3BP2
Ras GTPase-activating protein-binding protein 2

1

4

High-throughput

0.479

High

966670

TNR6B
Trinucleotide repeat-containing gene 6B protein

1

4

High-throughput

0.479

High

966671

SMG5
Nonsense-mediated mRNA decay factor SMG5

1

2

High-throughput

0.479

High

966672

SMC3
Structural maintenance of chromosomes protein 3

1

1

High-throughput

0.479

High

966674

NUDC
Nuclear migration protein nudC

1

1

High-throughput

0.479

High

966675

R3HD2
R3H domain-containing protein 2

1

4

High-throughput

0.479

High

966677

PRC2C
Protein PRRC2C

1

8

High-throughput

0.479

High

966678

YTHD2
YTH domain-containing family protein 2

1

6

High-throughput

0.479

High

966680

IF2B2
Insulin-like growth factor 2 mRNA-binding protein 2

1

10

High-throughput

0.479

High

234334

GSDME
Gasdermin-E

1

0

Small-scale

0.458

High

255695

OBSL1
Obscurin-like protein 1

1

0

High-throughput

0.458

High

257602

ANR17
Ankyrin repeat domain-containing protein 17

1

0

High-throughput

0.458

High

296898

LTN1
E3 ubiquitin-protein ligase listerin

1

0

High-throughput

0.458

High

298437

UFL1
E3 UFM1-protein ligase 1

1

0

High-throughput

0.458

High

314864

FMNL1
Formin-like protein 1

1

0

Small-scale

0.458

High

328812

TOP3B
DNA topoisomerase 3-beta-1

1

0

High-throughput

0.458

High

450842

F16P1
Fructose-1,6-bisphosphatase 1

1

0

High-throughput

0.458

High

684643

STIP1
Stress-induced-phosphoprotein 1

1

0

High-throughput

0.458

High

966520

KIF23
Kinesin-like protein KIF23

1

0

High-throughput

0.458

High

966546

HAPR1
HUWE1-associated protein modifying stress responses 1

1

0

High-throughput

0.458

High

966551

SMN
Survival motor neuron protein

1

0

Small-scale

0.458

High

966553

IF16
Gamma-interferon-inducible protein 16

1

0

High-throughput

0.458

High

966556

PDS5A
Sister chromatid cohesion protein PDS5 homolog A

1

0

High-throughput

0.458

High

966558

LSM12
Protein LSM12

1

0

High-throughput

0.458

High

966562

GLE1
mRNA export factor GLE1

1

0

High-throughput

0.458

High

966567

TUT4
Terminal uridylyltransferase 4

1

0

High-throughput

0.458

High

966581

NUFP2
FMR1-interacting protein NUFIP2

1

0

High-throughput

0.458

High

966584

WAPL
Wings apart-like protein homolog

1

0

High-throughput

0.458

High

966588

C2CD5
C2 domain-containing protein 5

1

0

High-throughput

0.458

High

966596

KDF1
Keratinocyte differentiation factor 1

1

0

High-throughput

0.458

High

966603

CABL1
CDK5 and ABL1 enzyme substrate 1

1

0

High-throughput

0.458

High

966622

CDCA5
Sororin

1

0

High-throughput

0.458

High

966626

CK5P3
CDK5 regulatory subunit-associated protein 3

1

0

High-throughput

0.458

High

966627

SNX27
Sorting nexin-27

1

0

High-throughput

0.458

High

966628

CBPC4
Cytosolic carboxypeptidase 4

1

0

High-throughput

0.458

High

966632

SEBP2
Selenocysteine insertion sequence-binding protein 2

1

0

High-throughput

0.458

High

966641

ZCHC2
Zinc finger CCHC domain-containing protein 2

1

0

High-throughput

0.458

High

966644

PKHA4
Pleckstrin homology domain-containing family A member 4

1

0

High-throughput

0.458

High

966655

CYLD
Ubiquitin carboxyl-terminal hydrolase CYLD

1

0

High-throughput

0.458

High

321055

PTBP3
Polypyrimidine tract-binding protein 3

1

4

High-throughput

0.445

High

346556

MYC
Myc proto-oncogene protein

1

2

High-throughput

0.445

High

717716

BMI1
Polycomb complex protein BMI-1

1

6

High-throughput

0.445

High

966534

CTBP1
C-terminal-binding protein 1

1

2

High-throughput

0.445

High

279516

FLOT1
Flotillin-1

1

1

High-throughput

0.437

High

966560

TTC31
Tetratricopeptide repeat protein 31

1

1

High-throughput

0.437

High

966565

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

1

0

High-throughput

0.426

High

354214

IGHD
Immunoglobulin heavy constant delta

1

1

High-throughput

0.407

High

373014

VTNC
Vitronectin

2

0

High-throughput

0.328

High

892751

C1QT8
Complement C1q tumor necrosis factor-related protein 8

1

0

High-throughput

0.279

Low

966554

ODAPH
Odontogenesis associated phosphoprotein

1

0

High-throughput

0.279

Low

966569

CP141
Cilia- and flagella-associated protein 141

1

0

High-throughput

0.279

Low

966583

TAFA3
Chemokine-like protein TAFA-3

1

0

High-throughput

0.279

Low

966593

CT197
Putative uncharacterized protein encoded by LINC02910

1

0

High-throughput

0.279

Low

966623

RUSF1
RUS family member 1

1

0

High-throughput

0.279

Low

966662

PEN2
Gamma-secretase subunit PEN-2

1

0

High-throughput

0.279

Low

966552

MOG
Myelin-oligodendrocyte glycoprotein

1

0

High-throughput

0.269

Low

966598

RN214
RING finger protein 214

1

0

High-throughput

0.249

Low

966605

DCAF4
DDB1- and CUL4-associated factor 4

1

0

High-throughput

0.249

Low

966651

LFG4
Protein lifeguard 4

1

0

High-throughput

0.249

Low

966660

MARH5
E3 ubiquitin-protein ligase MARCHF5

1

0

Small-scale

0.249

Low

966550

EREP1
Endosomal transmembrane epsin interactor 1

1

0

Small-scale

0.238

Low


Service provided by Combinatics, Japan

Last updated: 15 Jul 2024