HitPredict

Interactor 1: SKP2 (Q13309)
S-phase kinase-associated protein 2 (Cyclin-A/CDK2-associated protein p45) (F-box protein Skp2) (F-box/LRR-repeat protein 1) (p45skp2)
Gene: SKP2

Interactor 2: SMAD4 (Q13485)
Mothers against decapentaplegic homolog 4 (MAD homolog 4) (Mothers against DPP homolog 4) (Deletion target in pancreatic carcinoma 4) (SMAD family member 4) (SMAD 4) (Smad4) (hSMAD4)
Gene: SMAD4

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.67	0.60	0.634

Property	Details
Experiments	16865698, 15314162
Identification Methods	affinity chromatography technology, pull down, anti tag coimmunoprecipitation
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005829 - cytosol
Homologous interactions	4

Homologous interactions

Color coding for hit scores

	1 424 Hs			1 552
+	Hs
		950334 KDM2A_HUMAN (77-410): 3.55e-42: 161: 17.06		SMAD3_HUMAN (19-549): 1.96e-176: 506: 31.22
+	Dm
		785460 SCRIB_DROME (91-424): 5.74e-39: 151: 15.04		MAD_DROME (20-546): 3.27e-175: 504: 29.89
+	Hs
		167354 SKP2_HUMAN (1-424): 3e-94: 291: 100.00		SMAD7_HUMAN (33-137): 4.06e-26: 112: 28.45
+	Hs
		167411 KDM2A_HUMAN (77-410): 3.55e-42: 161: 17.06		SMAD7_HUMAN (33-137): 4.06e-26: 112: 28.45