Interactor 1: SKP2 (Q13309)
S-phase kinase-associated protein 2 (Cyclin-A/CDK2-associated protein p45) (F-box protein Skp2) (F-box/LRR-repeat protein 1) (p45skp2)
Gene: SKP2
Interactor 2: CUL1 (Q13616)
Cullin-1 (CUL-1)
Gene: CUL1
Species: Homo sapiens
Source: mint
Category: Small-scale
Confidence: High
| Method score | Annotation score | Interaction score |
|---|---|---|
| 0.99 | 1.00 | 0.995 |
The method score is based on:
| Property | Details |
|---|---|
| Experiments | 23770852, 27542266, 29103612, 32313199, 11961546, 18173839, 34237211, 37028429, 17439941, 21249194, 17438373, 21145461, 9663463, 9636170, 9736735, 23951410, 25143387, 22524983, 28514442, 28614300 and 27 others
more... |
| Identification Methods | affinity chromatography technology, x-ray crystallography, two hybrid, pull down, anti tag coimmunoprecipitation, tandem affinity purification, anti bait coimmunoprecipitation, coimmunoprecipitation |
| Interaction Type | physical association, association, direct interaction |
The annotation score is based on:
| Property | Details |
|---|---|
| Interacting Pfam domains | Cullin~F-box-like |
| Common GO terms | GO:0000082 - G1/S transition of mitotic cell cycle GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005829 - cytosol GO:0019005 - SCF ubiquitin ligase complex and 3 others more... |
| Homologous interactions | 20 |
Homologous interactions (Top 20)
Color coding for hit scores 
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Service provided by Combinatics, Japan
Last updated: 15 Jul 2024
