Protein: PGK
Phosphoglycerate kinase (EC 2.7.2.3)

Gene: PGK, PGK1
Organism: Saccharomyces cerevisiae S288C
Interactions: 227
UniProt ID: P00560

Gene Ontology (top 5):
GO:0004618 - phosphoglycerate kinase activity
GO:0005524 - ATP binding
GO:0005737 - cytoplasm
GO:0005739 - mitochondrion
GO:0005829 - cytosol

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

365505

PGK
Phosphoglycerate kinase

2

4

Small-scale

0.768

High

365511

HSP82
ATP-dependent molecular chaperone HSP82

4

4

High-throughput

0.672

High

365647

RPN11
Ubiquitin carboxyl-terminal hydrolase RPN11

3

2

High-throughput

0.640

High

365546

HSC82
ATP-dependent molecular chaperone HSC82

3

4

High-throughput

0.633

High

365537

HSP71
Heat shock protein SSA1

3

1

Small-scale

0.624

High

365539

SSB1
Ribosome-associated molecular chaperone SSB1

3

1

Small-scale

0.624

High

365562

RFA1
Replication factor A protein 1

2

1

High-throughput

0.621

High

365542

ALF
Fructose-bisphosphate aldolase

2

1

Small-scale

0.588

High

365566

SIS1
Protein SIS1

2

0

High-throughput

0.576

High

365629

SPF1
Endoplasmic reticulum transmembrane helix translocase

2

0

High-throughput

0.563

High

365643

LST8
Target of rapamycin complex subunit LST8

2

0

High-throughput

0.563

High

365620

RPN10
26S proteasome regulatory subunit RPN10

2

0

Small-scale

0.559

High

365632

SSB2
Ribosome-associated molecular chaperone SSB2

2

1

High-throughput

0.552

High

365585

ZUO1
Zuotin

2

0

Small-scale

0.547

High

365532

NFT1
ABC transporter NFT1

1

2

High-throughput

0.541

High

365626

YCFI
Metal resistance protein YCF1

1

1

High-throughput

0.541

High

365644

COPB2
Coatomer subunit beta'

2

1

High-throughput

0.537

High

365670

COPA
Coatomer subunit alpha

2

1

High-throughput

0.537

High

365637

MET18
DNA repair/transcription protein MET18/MMS19

1

1

High-throughput

0.536

High

365672

BRE5
UBP3-associated protein BRE5

1

2

High-throughput

0.536

High

365680

UBP3
Ubiquitin carboxyl-terminal hydrolase 3

1

1

High-throughput

0.536

High

365686

GCN5
Histone acetyltransferase GCN5

1

2

High-throughput

0.536

High

365599

PXA2
Peroxisomal long-chain fatty acid import protein 1

1

0

High-throughput

0.518

High

365646

BUD27
Bud site selection protein 27

1

0

Small-scale

0.518

High

365527

LTE1
Guanine nucleotide exchange factor LTE1

1

0

High-throughput

0.513

High

365528

CHS1
Chitin synthase 1

1

0

High-throughput

0.513

High

365588

PP12
Serine/threonine-protein phosphatase PP1-2

1

0

High-throughput

0.513

High

365641

MAD2
Mitotic spindle checkpoint component MAD2

1

0

High-throughput

0.513

High

365689

TCB3
Tricalbin-3

1

0

High-throughput

0.513

High

365690

ACL4
Assembly chaperone of RPL4

1

0

High-throughput

0.513

High

365699

ASR1
Alcohol-sensitive RING finger protein 1

1

0

High-throughput

0.513

High

365631

SHO1
High osmolarity signaling protein SHO1

1

0

Small-scale

0.493

High

365556

NUP1
Nucleoporin NUP1

1

3

High-throughput

0.489

High

365533

YK104
Putative uncharacterized protein YKR104W

1

1

High-throughput

0.481

High

365674

RHO5
GTP-binding protein RHO5

1

1

Small-scale

0.481

High

365536

SSBP1
Single-stranded nucleic acid-binding protein

1

0

High-throughput

0.480

High

365610

RCK1
Serine/threonine-protein kinase RCK1

1

0

High-throughput

0.480

High

358917

G3P2
Glyceraldehyde-3-phosphate dehydrogenase 2

1

4

High-throughput

0.479

High

359094

G3P3
Glyceraldehyde-3-phosphate dehydrogenase 3

1

4

High-throughput

0.479

High

359388

G3P1
Glyceraldehyde-3-phosphate dehydrogenase 1

1

4

High-throughput

0.479

High

361397

SODC
Superoxide dismutase [Cu-Zn]

1

1

High-throughput

0.479

High

364195

CDK1
Cyclin-dependent kinase 1

1

1

High-throughput

0.479

High

365506

ENO1
Enolase 1

1

3

High-throughput

0.479

High

365507

ENO2
Enolase 2

1

3

High-throughput

0.479

High

365509

PMG1
Phosphoglycerate mutase 1

1

3

High-throughput

0.479

High

365510

RS17A
Small ribosomal subunit protein eS17A

1

1

High-throughput

0.479

High

365513

HXKA
Hexokinase-1

1

1

High-throughput

0.479

High

365514

HXKB
Hexokinase-2

1

1

High-throughput

0.479

High

365515

METE
5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase

1

1

High-throughput

0.479

High

365526

SYSC
Serine--tRNA ligase, cytoplasmic

1

2

High-throughput

0.479

High

365529

SYIC
Isoleucine--tRNA ligase, cytoplasmic

1

1

High-throughput

0.479

High

365535

RS6A
Small ribosomal subunit protein eS6A

1

1

High-throughput

0.479

High

365543

CYPH
Peptidyl-prolyl cis-trans isomerase

1

1

High-throughput

0.479

High

365548

STI1
Heat shock protein STI1

1

4

High-throughput

0.479

High

365564

TKT1
Transketolase 1

1

2

High-throughput

0.479

High

365565

AATC
Aspartate aminotransferase, cytoplasmic

1

1

High-throughput

0.479

High

365570

CDC48
Cell division control protein 48

1

2

High-throughput

0.479

High

365575

HIBCH
Small ribosomal subunit protein mS47

1

1

High-throughput

0.479

High

365578

MCM4
DNA replication licensing factor MCM4

1

3

High-throughput

0.479

High

365584

EF1B
Elongation factor 1-beta

1

1

High-throughput

0.479

High

365589

FIMB
Fimbrin

1

2

Small-scale

0.479

High

365600

TCTP
Translationally-controlled tumor protein homolog

1

1

High-throughput

0.479

High

365605

MCM7
DNA replication licensing factor MCM7

1

2

High-throughput

0.479

High

365612

RS20
Small ribosomal subunit protein uS10

1

1

High-throughput

0.479

High

365613

6PGD1
6-phosphogluconate dehydrogenase, decarboxylating 1

1

1

High-throughput

0.479

High

365636

MLP2
Protein MLP2

1

1

High-throughput

0.479

High

365663

MCM6
DNA replication licensing factor MCM6

1

3

High-throughput

0.479

High

365673

GIS2
Zinc finger protein GIS2

1

1

High-throughput

0.479

High

365678

ACT
Actin

1

2

Small-scale

0.479

High

365679

NUM1
Nuclear migration protein NUM1

1

2

High-throughput

0.479

High

365685

TOM1
E3 ubiquitin-protein ligase TOM1

1

2

High-throughput

0.479

High

365687

STE20
Serine/threonine-protein kinase STE20

1

1

High-throughput

0.479

High

365692

RUVB1
RuvB-like protein 1

1

1

High-throughput

0.479

High

365695

EFM7
Protein N-terminal and lysine N-methyltransferase EFM7

1

1

High-throughput

0.479

High

365696

PUR8
Adenylosuccinate lyase

1

1

High-throughput

0.479

High

365715

DBP10
ATP-dependent RNA helicase DBP10

1

3

High-throughput

0.479

High

365717

RUVB2
RuvB-like protein 2

1

1

High-throughput

0.479

High

365718

SMC6
Structural maintenance of chromosomes protein 6

1

2

High-throughput

0.479

High

94521

STE2
Pheromone alpha factor receptor

1

0

High-throughput

0.460

High

365659

SC6B1
Protein transport protein SBH1

1

0

Small-scale

0.460

High

149442

RS9A
Small ribosomal subunit protein uS4A

1

0

High-throughput

0.458

High

357793

QCR7
Cytochrome b-c1 complex subunit 7, mitochondrial

1

0

High-throughput

0.458

High

360624

COX2
Cytochrome c oxidase subunit 2

1

0

High-throughput

0.458

High

360915

CCPR
Cytochrome c peroxidase, mitochondrial

1

0

Small-scale

0.458

High

364843

KPYK1
Pyruvate kinase 1

1

0

High-throughput

0.458

High

365508

TPIS
Triosephosphate isomerase

1

0

High-throughput

0.458

High

365512

RL25
Large ribosomal subunit protein uL23

1

0

High-throughput

0.458

High

365516

RL26A
Large ribosomal subunit protein uL24A

1

0

High-throughput

0.458

High

365517

RS3
Small ribosomal subunit protein uS3

1

0

High-throughput

0.458

High

365518

RS13
Small ribosomal subunit protein uS15

1

0

High-throughput

0.458

High

365519

PDC1
Pyruvate decarboxylase isozyme 1

1

0

High-throughput

0.458

High

365520

RS14A
Small ribosomal subunit protein uS11A

1

0

High-throughput

0.458

High

365521

KAD2
Adenylate kinase

1

0

High-throughput

0.458

High

365523

DHE4
NADP-specific glutamate dehydrogenase 1

1

0

High-throughput

0.458

High

365524

KAPR
cAMP-dependent protein kinase regulatory subunit

1

0

Small-scale

0.458

High

365525

RS19A
Small ribosomal subunit protein eS19A

1

0

High-throughput

0.458

High

365530

RS22A
Small ribosomal subunit protein uS8A

1

0

High-throughput

0.458

High

365531

RL31A
Large ribosomal subunit protein eL31A

1

0

High-throughput

0.458

High

365540

G6PI
Glucose-6-phosphate isomerase

1

0

High-throughput

0.458

High

365541

CAF20
Cap-associated protein CAF20

1

0

High-throughput

0.458

High

365545

TAL1
Transaldolase

1

0

High-throughput

0.458

High

365549

THRC
Threonine synthase

1

0

High-throughput

0.458

High

365553

PGTB1
Geranylgeranyl transferase type-1 subunit beta

1

0

High-throughput

0.458

High

365555

IRA2
Inhibitory regulator protein IRA2

1

0

Small-scale

0.458

High

365558

OSM1
Fumarate reductase 2

1

0

High-throughput

0.458

High

365559

CBP3
Protein CBP3, mitochondrial

1

0

High-throughput

0.458

High

365560

XRN1
5'-3' exoribonuclease 1

1

0

High-throughput

0.458

High

365561

RPC2
DNA-directed RNA polymerase III subunit RPC2

1

0

High-throughput

0.458

High

365563

KCC2
Calcium/calmodulin-dependent protein kinase II

1

0

High-throughput

0.458

High

365567

RS2
Small ribosomal subunit protein uS5

1

0

High-throughput

0.458

High

365568

GID7
GID complex subunit 7

1

0

High-throughput

0.458

High

365569

HSP30
30 kDa heat shock protein

1

0

High-throughput

0.458

High

365571

SPB4
ATP-dependent rRNA helicase SPB4

1

0

High-throughput

0.458

High

365573

RS7A
Small ribosomal subunit protein eS7A

1

0

High-throughput

0.458

High

365579

RENT1
ATP-dependent helicase NAM7

1

0

Small-scale

0.458

High

365580

DHOM
Homoserine dehydrogenase

1

0

High-throughput

0.458

High

365581

HS104
Heat shock protein 104

1

0

High-throughput

0.458

High

365582

P5CR
Pyrroline-5-carboxylate reductase

1

0

High-throughput

0.458

High

365583

RM41
Large ribosomal subunit protein uL23m

1

0

High-throughput

0.458

High

365586

CBS
Cystathionine beta-synthase

1

0

High-throughput

0.458

High

365591

RSSA1
Small ribosomal subunit protein uS2A

1

0

High-throughput

0.458

High

365592

SMY2
Protein SMY2

1

0

High-throughput

0.458

High

365594

YPT7
Ypt/Rab-type GTPase YPT7

1

0

Small-scale

0.458

High

365595

PRS6A
26S proteasome regulatory subunit 6A

1

0

High-throughput

0.458

High

365597

RS3A1
Small ribosomal subunit protein eS1A

1

0

High-throughput

0.458

High

365602

RS27A
Small ribosomal subunit protein eS27A

1

0

High-throughput

0.458

High

365604

RM28
Large ribosomal subunit protein mL40

1

0

High-throughput

0.458

High

365606

GID4
GID complex substrate-recognition subunit 4

1

0

High-throughput

0.458

High

365607

AIM4
Altered inheritance of mitochondria protein 4

1

0

High-throughput

0.458

High

365611

NCB5R
NADH-cytochrome b5 reductase 1

1

0

High-throughput

0.458

High

365614

ECM29
Proteasome component ECM29

1

0

High-throughput

0.458

High

365615

RPN1
26S proteasome regulatory subunit RPN1

1

0

High-throughput

0.458

High

365616

SSZ1
Ribosome-associated complex subunit SSZ1

1

0

Small-scale

0.458

High

365617

NMD2
Nonsense-mediated mRNA decay protein 2

1

0

Small-scale

0.458

High

365619

LNP
Endoplasmic reticulum junction formation protein lunapark

1

0

High-throughput

0.458

High

365625

TCPZ
T-complex protein 1 subunit zeta

1

0

High-throughput

0.458

High

365627

DHH1
ATP-dependent RNA helicase DHH1

1

0

High-throughput

0.458

High

365628

LAA1
AP-1 accessory protein LAA1

1

0

High-throughput

0.458

High

365633

MMF1
Protein MMF1, mitochondrial

1

0

High-throughput

0.458

High

365638

FIS1
Mitochondrial fission 1 protein

1

0

Small-scale

0.458

High

365642

GPP1
Glycerol-1-phosphate phosphohydrolase 1

1

0

High-throughput

0.458

High

365654

UPF3
Nonsense-mediated mRNA decay protein 3

1

0

Small-scale

0.458

High

365656

RS12
Small ribosomal subunit protein eS12

1

0

High-throughput

0.458

High

365661

ERG25
C-4 methylsterol oxidase ERG25

1

0

High-throughput

0.458

High

365662

VID30
GID complex subunit 1

1

0

High-throughput

0.458

High

365664

YGK8
Uncharacterized protein YGL108C

1

0

High-throughput

0.458

High

365665

GET1
Golgi to ER traffic protein 1

1

0

High-throughput

0.458

High

365666

PIL1
Sphingolipid long chain base-responsive protein PIL1

1

0

High-throughput

0.458

High

365676

SAM50
Sorting assembly machinery 50 kDa subunit

1

0

High-throughput

0.458

High

365681

RS15
Small ribosomal subunit protein uS19

1

0

High-throughput

0.458

High

365684

COFI
Cofilin

1

0

High-throughput

0.458

High

365688

OYE2
NADPH dehydrogenase 2

1

0

High-throughput

0.458

High

365691

GIS1
Transcriptional activator/repressor GIS1

1

0

High-throughput

0.458

High

365693

SEG1
Eisosome protein SEG1

1

0

High-throughput

0.458

High

365702

ZEO1
Protein ZEO1

1

0

High-throughput

0.458

High

365705

SGO1
Shugoshin

1

0

High-throughput

0.458

High

365706

TCO89
Target of rapamycin complex 1 subunit TCO89

1

0

High-throughput

0.458

High

365708

YIG1
Protein YIG1

1

0

High-throughput

0.458

High

365713

PST1
Cell wall mannoprotein PST1

1

0

High-throughput

0.458

High

365557

PUR6
Phosphoribosylaminoimidazole carboxylase

1

2

High-throughput

0.457

High

365522

ADR1
Regulatory protein ADR1

1

1

High-throughput

0.445

High

365534

UBI4P
Polyubiquitin [Cleaved into: Ubiquitin]

1

6

High-throughput

0.445

High

365538

HSP72
Heat shock protein SSA2

1

1

High-throughput

0.445

High

365544

SEC63
Protein translocation protein SEC63

1

1

High-throughput

0.445

High

365572

BUB2
Mitotic check point protein BUB2

1

1

High-throughput

0.445

High

365587

HSP7F
Heat shock protein homolog SSE1

1

4

High-throughput

0.445

High

365590

GLRX4
Monothiol glutaredoxin-4

1

6

High-throughput

0.445

High

365608

CLPX
ATP-dependent clpX-like chaperone, mitochondrial

1

3

High-throughput

0.445

High

365622

TCPB
T-complex protein 1 subunit beta

1

1

High-throughput

0.445

High

365623

TCPG
T-complex protein 1 subunit gamma

1

1

High-throughput

0.445

High

365624

TCPD
T-complex protein 1 subunit delta

1

2

High-throughput

0.445

High

365630

HSP7E
Heat shock protein SSC3, mitochondrial

1

2

High-throughput

0.445

High

365651

TCPQ
T-complex protein 1 subunit theta

1

2

High-throughput

0.445

High

365704

GYP1
GTPase-activating protein GYP1

1

1

High-throughput

0.445

High

365683

ULP1
Ubiquitin-like-specific protease 1

1

1

High-throughput

0.439

High

365552

PDI
Protein disulfide-isomerase

1

5

High-throughput

0.437

High

365576

TF2B
Transcription initiation factor IIB

1

1

High-throughput

0.437

High

365577

TF3B
Transcription factor IIIB 70 kDa subunit

1

1

High-throughput

0.437

High

365640

RLP7
Ribosome biogenesis protein RLP7

1

1

High-throughput

0.437

High

365682

MLP1
Protein MLP1

1

1

High-throughput

0.437

High

365700

BRE1
E3 ubiquitin-protein ligase BRE1

1

1

Small-scale

0.437

High

365707

AP3D
AP-3 complex subunit delta

1

1

High-throughput

0.437

High

365712

SMT3
Ubiquitin-like protein SMT3

1

3

High-throughput

0.437

High

365550

BIP
Endoplasmic reticulum chaperone BiP

1

0

High-throughput

0.426

High

365554

DDR48
Stress protein DDR48

1

0

High-throughput

0.426

High

365621

TVP23
Golgi apparatus membrane protein TVP23

1

0

High-throughput

0.426

High

365635

ATM1
Iron-sulfur clusters transporter ATM1, mitochondrial

1

0

High-throughput

0.426

High

365650

JJJ2
J protein JJJ2

1

0

High-throughput

0.426

High

365658

CWC23
Pre-mRNA-splicing factor CWC23

1

0

High-throughput

0.426

High

365675

APJ1
J domain-containing protein APJ1

1

0

High-throughput

0.426

High

365711

NCE2
Non-classical export protein 2

1

0

High-throughput

0.426

High

365719

RRP12
Ribosomal RNA-processing protein 12

1

0

High-throughput

0.426

High

365601

YET1
Endoplasmic reticulum transmembrane protein 1

1

1

High-throughput

0.407

High

365703

MED7
Mediator of RNA polymerase II transcription subunit 7

2

0

High-throughput

0.307

High

365714

RPN6
26S proteasome regulatory subunit RPN6

2

0

High-throughput

0.307

High

365639

DSN1
Kinetochore-associated protein DSN1

2

0

High-throughput

0.305

High

365551

SPO12
Sporulation-specific protein 12

1

0

High-throughput

0.279

Low

365603

RPF2
Ribosome biogenesis protein RPF2

1

0

High-throughput

0.279

Low

365660

SCS3
Acyl-coenzyme A diphosphatase SCS3

1

0

Small-scale

0.251

Low

365547

SEC11
Signal peptidase complex catalytic subunit SEC11

1

0

High-throughput

0.249

Low

365574

PEX3
Peroxisomal biogenesis factor 3

1

0

High-throughput

0.249

Low

365593

SC61A
Protein transport protein SEC61

1

0

High-throughput

0.249

Low

365596

IXR1
Intrastrand cross-link recognition protein

1

0

Small-scale

0.249

Low

365598

PMT1
Dolichyl-phosphate-mannose--protein mannosyltransferase 1

1

0

High-throughput

0.249

Low

365609

YB8A
Putative uncharacterized protein YBR285W

1

0

Small-scale

0.249

Low

365618

GPI16
GPI transamidase component GPI16

1

0

High-throughput

0.249

Low

365649

PHO86
Inorganic phosphate transporter PHO86

1

0

High-throughput

0.249

Low

365652

MOG1
Nuclear import protein MOG1

1

0

High-throughput

0.249

Low

365653

EMC2
ER membrane protein complex subunit 2

1

0

High-throughput

0.249

Low

365657

VATG
V-type proton ATPase subunit G

1

0

High-throughput

0.249

Low

365667

PESC
Pescadillo homolog

1

0

High-throughput

0.249

Low

365669

RRN9
RNA polymerase I-specific transcription initiation factor RRN9

1

0

High-throughput

0.249

Low

365677

ASI3
Probable ERAD-associated E3 ubiquitin-protein ligase ASI1

1

0

High-throughput

0.249

Low

365694

POB3
FACT complex subunit POB3

1

0

High-throughput

0.249

Low

365697

TFC6
Transcription factor tau 91 kDa subunit

1

0

High-throughput

0.249

Low

365698

URN1
Pre-mRNA-splicing factor URN1

1

0

High-throughput

0.249

Low

365709

HFI1
SAGA complex subunit HFI1

1

0

Small-scale

0.249

Low

365710

SPC3
Signal peptidase complex subunit 3

1

0

High-throughput

0.249

Low

365634

JEM1
DnaJ-like chaperone JEM1

1

0

High-throughput

0.232

Low

365645

EMP47
Protein EMP47

1

0

High-throughput

0.232

Low

365648

ERJ5
ER-localized J domain-containing protein 5

1

0

High-throughput

0.232

Low

365655

SEC16
COPII coat assembly protein SEC16

1

0

High-throughput

0.232

Low

365668

SCW4
Probable family 17 glucosidase SCW4

1

0

High-throughput

0.232

Low

365671

ALG12
Dol-P-Man:Man(7)GlcNAc(2)-PP-Dol alpha-1,6-mannosyltransferase

1

0

High-throughput

0.232

Low

365701

RSC58
Chromatin structure-remodeling complex protein RSC58

1

0

High-throughput

0.232

Low

365716

PEX11
Peroxisomal membrane protein PMP27

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025