HitPredict

Interactor 1: SKP2 (Q13309)
S-phase kinase-associated protein 2 (Cyclin-A/CDK2-associated protein p45) (F-box protein Skp2) (F-box/LRR-repeat protein 1) (p45skp2)
Gene: SKP2

Interactor 2: UBP18 (Q9UMW8)
Ubl carboxyl-terminal hydrolase 18 (EC 3.4.19.12) (43 kDa ISG15-specific protease) (hUBP43) (ISG15-specific-processing protease) (Ubl thioesterase 18)
Gene: USP18

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.81	0.60	0.698

Property	Details
Experiments	25307056, 30068654, 30858391, 15342634
Identification Methods	affinity chromatography technology, two hybrid, pull down, anti bait coimmunoprecipitation
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005829 - cytosol
Homologous interactions	4

Homologous interactions

Color coding for hit scores

	1 424 Hs			1 372
+	Hs
		1031246 SKP2_HUMAN (1-424): 3e-94: 291: 100.00		UBP7_HUMAN (47-369): 1.37e-109: 346: 25.00
+	Hs
		271087 SKP2_HUMAN (1-424): 3e-94: 291: 100.00		UBP2_HUMAN (10-368): 1.33e-99: 309: 21.27
+	Hs
		1031300 SKP2_HUMAN (1-424): 3e-94: 291: 100.00		UBP21_HUMAN (11-371): 1.51e-96: 299: 18.51
+	Hs
		1031238 SKP2_HUMAN (1-424): 3e-94: 291: 100.00		UBP33_HUMAN (205-369): 1.09e-15: 80.5: 33.74